<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05075

Description Mediator of RNA polymerase II transcription subunit 26
SequenceMCVDNGNSTSIYILHNKTQANPQYATSVINYSTKSDIVIGPVATPFTQMMPTKLYKVVDMHAVNEIISILEKINITKELLEVVDMHAVNEIISILEKINITKELLETTRLGKHVNELRRKTTDQTLARRAKILVKRWRDLVIPAVSSPAHTGSNRSSAERQMRRLGGTPLTSPALTRNVVSPAVPSPRMQARPAWGGYESDSQDVILVDDEPPTALPPPPIAPLAPLAPFATQKPLTPTPTTTPTPPIKRQPSPELVHDDKKAKRDKKPKKRRGHSRAGSGTEAGGVGEGDAGVEGGGVWGARNGSAHHERRRNGCRRDALDAYSALVNRMPPAGAKKVKTTKELLEQIQSRGSKPASRPASPSSPASPASPDVMLIEPDSFPKAASPLRNGSSEPGRGAPPPARPASPLPPRSPLDEELAAERETCTCEEEAQETCPAASRRRTAPLHVLALHNALLPGVNGTRAPLHPHQFAVRKLADHERPGLFTSVVPLYKYSDYADDYCVKNLSRVTLCKHIPVDEFAPPPPDIPAPPSPPSPRPYPVDEETEAPEIKPEPECVKTEVMEYECPEVQPEMVSVPSLEPSERLKAPLLSVEDERQFGAEPIVKMEVEEQFVSEPQEHRTVERTKEELDGKGLYALCQRAMDAIPYSYAQAASAPVLSLSAVEQGATLEEVDSCPDELGRPQRAPRFAEWHECARLGDLIALPYVVID
Length711
PositionUnknown
OrganismPapilio machaon (Old World swallowtail butterfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Papilionoidea> Papilionidae> Papilioninae> Papilio.
Aromaticity0.04
Grand average of hydropathy-0.537
Instability index69.93
Isoelectric point6.24
Molecular weight77615.34
Publications
PubMed=26354079

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05075
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.72|      19|      24|      58|      81|       1
---------------------------------------------------------------------------
   52-   71 (33.09/18.15)	TK.LYKvVDMHAVNEIISILE
   76-   96 (29.63/32.71)	TKeLLEvVDMHAVNEIISILE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     377.22|     104|     121|     201|     321|       3
---------------------------------------------------------------------------
  201-  312 (168.89/73.58)	DSQDVIL.....VDD...............EPPTALPPP..PIAPLAPLAPFatQKP................LTPTPTTTPTPPIKRQ.P..SPELVH..DDKKAKRDKKPKkrrgHSRAGSGTEAGGVGEGDAGVEGGGvWGARNgSAHHERR
  370-  484 (161.78/56.70)	ASPDVML.....IEPdsfpkaasplrngssEPGRGAPPParPASPLPPRSPL..DEE................LAAERETCTCEEEAQE.T..CP........AASRRRTAPL....HVLALHNALLPGVNGTRAPLHPHQ.FAVRK.LADHERP
  511-  590 (46.55/ 9.67)	....VTLckhipVDE...............FAP...PPP..DI.P.APPSP......psprpypvdeeteapeIKPEPECVKTEVMEYEcPevQPEMVSvpSLEPSERLKAP...........................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.01|      16|      22|     138|     158|       4
---------------------------------------------------------------------------
  138-  153 (29.44/ 9.07)	RDLVIPAVSSPAHTGS
  163-  178 (27.57/13.99)	RRLGGTPLTSPALTRN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.34|      10|     239|      97|     106|       6
---------------------------------------------------------------------------
   97-  106 (17.32/11.94)	KINITKELLE
  338-  347 (17.02/11.62)	KVKTTKELLE
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05075 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FAPPPPDIPAPPSPPSPRPYPVDEETEAPEIKPEPECV
2) PAHTGSNRSSAERQMRRLGGTPLTSPALTRNVVSPAVPSPRMQARPAWGGYESDSQDVILVDDEPPTALPPPPIAPLAPLAPFATQKPLTPTPTTTPTPPIKRQPSPELVHDDKKAKRDKKPKKRRGHSRAGSGTEAGGVGEGDAGVEGGGVWGARNGSAHHERRRNGCRRDALDAYSALVNRMPPAGAKKVKTTKELLEQIQSRGSKPASRPASPSSPASPASPDVMLIEPDSFPKAASPLRNGSSEPGRGAPPPARPASPLPPRSPLDEELAAERETCTCEEEAQETCPAASRRRTA
522
148
559
446










Molecular Recognition Features






MoRF SequenceStartStop




1) ELLEQ
2) LVHDDK
344
256
348
261