<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05072

Description Mediator of RNA polymerase II transcription subunit 26
SequenceMCFVSRPDLSAPRFERWRCGGHPDRGVCLRHSQRDCNYFYLYQFVQLLVQLQVVDMHAVNEIISILEKINITKELLETTRLGKHVNELRRKTTDQTLARRAKVLVKRWRDLVIPAVASPAHTGSNRSSAERQMRRLGGTPLTSPALSRNVVSPAVPSPRTQARPAWGGYESDSQDVILVDDEPPTALPPPSIAPLAPLAPLATQKPLTPTPMTTPTPTPPIKRQPSPEPVHDDKKAKRDKKPKKRRGHSRAGSGTESGGVAEGGVGTEGGGAWTARNGSAHHERRRNGCRRDALDAYSALVNRMPPAGAKKVKTTKELLEQIQSRGTRPASRPVSPASPASPDVMLIEPDSYTKAASPLRNGSSEPAPLPALAAPPSPVAPRSPLDEELAAEREACTCEEEAQEACPAAPRRRTAPLHVLALHNALLPGVNGTRAPLHPHQFAVRKLADPERPELFTSVVPLYKYSDYADDYCVKNLSRVTLCKHIPVDEFAPPPPDIPPPPSPPPPRPYPVDEEVEAPEIKPEPECVKTEVMEYECPKVEPEMVSVPSLEPSERLKAPLLTVEDERQFGAEPVVKMEVEEEFVSEPQEHRTVERTKEELDGKGLYALCQRAMDAIPYSYAQAGSAPVLSLAAAEQGAMLEEVDSCPDEMGRPQRAPRFAEWHECARLGDLIALPYVVID
Length680
PositionUnknown
OrganismPapilio xuthus (Asian swallowtail butterfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Papilionoidea> Papilionidae> Papilioninae> Papilio.
Aromaticity0.05
Grand average of hydropathy-0.566
Instability index73.81
Isoelectric point6.40
Molecular weight74634.09
Publications
PubMed=26354079

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05072
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     133.61|      37|      38|     329|     365|       1
---------------------------------------------------------------------------
  182-  232 (40.38/10.61)	EPPTALPPP....SIAplaplaplatqkpltptPM.....TTP.TPTPPikRQPSPEPVHD
  313-  349 (54.47/16.64)	KTTKELLEQIQSRGTR.................PA.....SRPVSPASP..ASPDVMLIEP
  350-  384 (38.75/ 9.91)	DSYTKAASPLRNGSSE.................PAplpalAAPPSPVAP..RSP.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.42|      11|      38|     109|     119|       2
---------------------------------------------------------------------------
  109-  119 (20.64/10.80)	RDLVIPAVASP
  148-  158 (21.78/11.84)	RNVVSPAVPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     331.64|      73|     125|     386|     458|       3
---------------------------------------------------------------------------
  386-  453 (109.18/45.23)	.....D............EELAA.....EREACTCEEE...AQEACP.AAPRRRTAPLHVLAL..HNALLPGVNGTRAPL....HPHQFAVRKLADPERP
  454-  509 (83.04/32.67)	ELFTS.................................vvpLYKYSD.YADDYCVKNLSRVTL..CKH.IP.VDEFAPP......PPDIPPPPSPPPPRP
  513-  580 (67.16/25.05)	.....D............EEVEApeikpEPE.CVKTEV...MEYECPkVEPEMVSVP..........SLEPS.ERLKAPLltveDERQFGAEPVVKMEVE
  581-  658 (72.26/27.50)	EEFVS.epqehrtvertkEELDG.....KGLYALC.QR...AMDAIPySYAQAGSAPVLSLAAaeQGAMLEEVDSCPDEM....GRPQRAPR........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.58|      15|      16|     247|     261|       4
---------------------------------------------------------------------------
  247-  261 (27.18/17.17)	GHSRAGSG..TESGGVA
  264-  280 (22.40/12.92)	GVGTEGGGawTARNGSA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05072 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EFAPPPPDIPPPPSPPPPRPYPVDEEVEAPEIKPEP
2) PAHTGSNRSSAERQMRRLGGTPLTSPALSRNVVSPAVPSPRTQARPAWGGYESDSQDVILVDDEPPTALPPPSIAPLAPLAPLATQKPLTPTPMTTPTPTPPIKRQPSPEPVHDDKKAKRDKKPKKRRGHSRAGSGTESGGVAEGGVGTEGGGAWTARNGSAHHERRRNGCRRDALDAYSALVNRMPPAGAKKVKTTKELLEQIQSRGTRPASRPVSPASPASPDVMLIEPDSYTKAASPLRNGSSEPAPLPALAAPPSPVAPRSPLDEELAAERE
490
119
525
394










Molecular Recognition Features






MoRF SequenceStartStop




1) VHDDKKA
230
236