Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDTYIDGRFERLEKALANLIDSVTKFHPSIQQGDELDAADKELSKGLEEVQTHQNNYLRIQQLRESSAALDTQIRETLSNLATTRKDIVTTHTTTFPAGPSYAIAYEELLNYARRISKTTMPPAGTIKAAPATAAPPTPDGQTPGVQTPGPESQTASVMTPSAPPSSQVQSPAVMNGTPHVSQDPATQQSTMSANTSLPSEWTQFLNPLTDQIFLPWPNDLQLGAGALAAHQVLLEQGINPKGYDPAEEEERKRLEEEERKKKEEEDRIAQEEREKKLREERERQRIERERQREKDQEAWRRASLVGGPAAPGEQRSPTGRPQQQAQFQFTNLDDLDDDDDDD |
Length | 343 |
Position | Middle |
Organism | Fusarium langsethiae |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.992 |
Instability index | 57.07 |
Isoelectric point | 4.78 |
Molecular weight | 38291.63 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP05069 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 41.97| 14| 15| 256| 269| 1 --------------------------------------------------------------------------- 256- 269 (24.21/14.17) EEEERKKKEEED..RI 272- 287 (17.77/ 8.61) EEREKKLREERErqRI --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 70.07| 23| 28| 76| 103| 2 --------------------------------------------------------------------------- 76- 103 (33.07/28.92) ETLSNLAttRKdivTTHTTTFPAG.....PSYA 107- 134 (37.01/19.03) EELLNYA..RR...ISKTTMPPAGtikaaPATA --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 65.76| 17| 27| 135| 151| 3 --------------------------------------------------------------------------- 135- 151 (34.45/25.19) APPTPDGQTPGVQTPGP 163- 179 (31.31/22.09) APPSSQVQSPAVMNGTP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 90.44| 29| 30| 10| 39| 4 --------------------------------------------------------------------------- 10- 39 (43.12/33.56) ERLEKALANlIDSVTKFHPSIQQGDELDAA 41- 69 (47.32/32.16) KELSKGLEE.VQTHQNNYLRIQQLRESSAA --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) QEAWRRASLVGGPAA 2) RPQQQAQFQFTNLDDLDD | 297 321 | 311 338 |
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