<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05063

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVVMDNVNIEGSVRRPGLNEARNGVPNAFDNADKPDQLSGMNGSVYVNGASSGIAASNQHPRMLADKTVEIVPTSPFKLPHITQGFFPFGTLVNRSVQECWNELSELITELATIQVPASGGSISTNGKPAGNQSSENVHKKLRLLDFAHAKRAEFIKLLVLSQWSRQAADVSRLIDIQGFIRTRHQSYDAALQYVGEVKRDLVRAQVANPDLKTAVEVLSKGRVASLPDLGYKPPTPLTARATLKKLLKLNRIISVRLALHDSVPPPLRNYRVHDGRVTFTTSGEFELDLSVAEESKTSQFFFVDIRFLFSPSSPIPKGRIFNELDGKINDLLRDDGLAGCFQFLHGLVLTNKINILFKQAVDLSRGLWADALRIELLHRTLVVQYWPQRSGPKSWLEIGVKSGHRGGSSSDPKPGISHLGFRWMRDGQQVSSDAIRFNPGDLSMELILRSVIALHTSHLLSAAFTTLKKHVLFSNHTLSLQAQLSPTEPGDCRLDVQLTASRSLRVSIEPMSGSITMCRTPHVLERLDGDRGLYKSSIEEILSRVARLRCTTAVDEIDSGTKALGLESVNQRVLGLDPRKLFPPGVMRTAFFTHRLWNRHWVAAATSSMDGDRWWLVQLRPTQPTKMGQFHSIGDHSVAAPQAHVVSETLVPPQRRLNYTTCAELVHGITGILAIHANARYLADLPAMNFWPTFKELQLETDLTVPDLLFNYNSSTLPPAFRVTLPFGAKKQSQFKEMIRLVFHGIDSQTRSVIIMAHGSLKTRIKSLVPLVSSTDPSLIIQDKGSGFALRLLVPAGHPVVACLFELLQRLECVLSILQSLIRKGMEPRSLSLSRIDFAYGPEHKFPAFFDMSAKGPSLSDYVDVADAISKTTPLFQLKLGIQFESSSPHCRIQEPLTVALNQRFTESGVESTLQLLATTLPLLRSLDQVTPQSNQTDLSIVQVIARKPTVYLIHYPRLRSRFHLSAVMHQDHLVWMLRDANGMDQSGRGQVAAFIQEKLYQSKGDGWNGLGDGAVASINKIGNLILELHECLNAPHLQLDKEVEVKPEQIPKQLHIKGSTSAAPQTMGNTDVITID
Length1080
PositionTail
OrganismPenicillium nordicum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.150
Instability index45.64
Isoelectric point9.20
Molecular weight119559.94
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05063
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.41|      40|      94|     446|     496|       1
---------------------------------------------------------------------------
  446-  492 (49.77/41.80)	SMELIlrsVIALHTSHLLSAAFTTLKkhvLFSNhTLSLQAQLSPTEP
  896-  935 (62.64/38.35)	IQEPL...TVALNQRFTESGVESTLQ...LLAT.TLPLLRSLDQVTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     222.32|      74|     617|      49|     130|       2
---------------------------------------------------------------------------
   49-  130 (112.70/102.05)	VNGAsSGIAASNQHPRMLAD.KTVEIVPTspFK.....................LPHITQGFFPFGTlvnrSVQECWNELSELI.....TELATIQVPASgGSISTNGK
  669-  769 (109.61/74.04)	VHGI.TGILAIHANARYLADlPAMNFWPT..FKelqletdltvpdllfnynsstLPPAFRVTLPFGA....KKQSQFKEMIRLVfhgidSQTRSVIIMAH.GSLKTRIK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.73|      27|     573|     294|     322|       3
---------------------------------------------------------------------------
  294-  322 (43.97/34.53)	VAEE.SKTSQFFFVDIRFLFSPSSpiPKGR
  868-  895 (44.76/27.93)	VADAiSKTTPLFQLKLGIQFESSS..PHCR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05063 with Med14 domain of Kingdom Fungi
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