Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDQSIDSRFERLEKALAALIDSVTKYHPSTTHAEELRAADQDLGRGLLEVQTHQNNYLRIQQLRRLSASLDAQIRETLISLAATRKDIVTTQTTSYPPGDSYPVTYGELLQYARRISKTTMPPASALSSVPPPPPQQQQQQQQAPPAQPAPAGSSSASASANGLAQQQQQQQSGAESSAQPASMHTSLPDGMSQYLNPLSGQIFFPWPPEDKIRSGALASNQILSEQGIDPRGFDPVLEEDRRRREEEERKEREEREKQERADKERAMREEMERIRLERERQREKEQAEWRRASVAGASADAPGAAARGAPGAGEKKQFQFTNLDDLDDDDDDDDD |
Length | 336 |
Position | Middle |
Organism | Escovopsis weberi |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Escovopsis. |
Aromaticity | 0.04 |
Grand average of hydropathy | -1.041 |
Instability index | 66.02 |
Isoelectric point | 4.92 |
Molecular weight | 37459.59 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP05061 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 72.74| 23| 29| 125| 150| 1 --------------------------------------------------------------------------- 95- 128 (29.49/10.56) SYPPGdsyPVTYGELLQYArriskttmP...PASALS 129- 154 (43.25/25.68) SVPPP...PPQQQQQQQQA........PpaqPAPAGS --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 67.69| 21| 25| 242| 266| 2 --------------------------------------------------------------------------- 245- 266 (33.03/21.55) REEEERKeREEREKQ...ERADKER 269- 292 (34.67/12.22) REEMERI.RLERERQrekEQAEWRR --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 44.94| 11| 29| 204| 214| 3 --------------------------------------------------------------------------- 204- 214 (24.33/18.10) FFPWPPEDKIR 234- 244 (20.61/14.13) FDPVLEEDRRR --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) EKKQFQFTNLDDLDDD 2) WRRASVAGA | 315 290 | 330 298 |
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