<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05054

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMVIRRSTERSNDWLKPVDDDEDEGFLALAEDGDAESKGILDEGNRSTLNLTTAELPVYMTIHRVRRLVLASIDDPYTMEHFRDPKMNALVVRPLVERLYNPDDISVVYCLLANRVSFLRDQSAEVHQSVNQARAILCELLASRVLRRFHEDNPGPQGLLLLSHILVEGFDPFQGAPSHMERPANRPQWPGASPDSPGSERKLTALELAIVSESKFFISSAACQRAVDAVHNGQIIYTPLSFMDFLPDYYKRRPISLYDPRTAPLLNHHRLIVPRNRNLIELVHFVILLILYVMTMVSRHSEVNMWEFAFCIYTFGWLLEKMAAIIEHGWAVHAQNLWAFLDITFGSIFGAYFVLRIYDFLLDQLHSGYGLPILCIAAPVMLTRVAFNLLPNNLVFISVHAMMKDFTMLTFLATWCFTGFLLALQWLVSASNDGDEEFSWYVVGKWMLWIWFGLDGEGIEESVRFHIIIGPALMIAFAFLGNTLFLTILIAMLTNTFSKIVADETAEIQFRRAVLTFEGVKSDSIFAYPPPFNILALMTLLPLKLVTSARIFHIVNVALIRTLNMPTLLLISFVERRRLWMQSRRAAGKRSKWQFTSLSPHNDVQAVFKSVPPTEISDIIDQLDPLGEVPILEDDLMPTMTADNPQSKLRRVRMLQREGHRRTGGNETWSSASSVQDEALENETPQRTPTNRAIMTLGGDSQPLSLRPPPVADRKPRNIAEFITRVNAQPGGFRALSEAKLKEEIAQENATNGDSQQKDVDMDEADEDDDEEDQDATRDLQEVRMEMFKNLDIAGNTALLTLDFLSLLISKQNPTQAGVTLSQGLRDMVGIGTIGADKLDNSPITSVKAQEQENIALGFTLMQTNKVRDAAEAASSVLQKQVTAEGRYWEDIVAVQKSGWSITRVPMERHTLGVRFGFSEAAPEYRNSLAPMRRGSDGTVQLDCGKLGGVSERVVVTYERDGQITGRSALPAETAVDAPLEEHVLEARNTIFSQELWHELTREARTLAAYDVKPDGSRLTCDIDPESKSRIILELVPLGTYASSDDSLPDNHIAETISLSLHILLGYAHRQNELLRTRPMPPHIPRSRGQQIHALLRPIIARLMHFQNVKTVTQHVGDLVKSLQRAGISSSFVLSTPKMSPSDSDPSNQGPNQLASSQAMIKNMLNHIEFNIKLTILPNITCTVRGRTFQVPVTATHYTVLLPPNSPLSSVCAPYKEGYPDPNALADYLGTATSRLLVEHYLSNLSPPWTRSIQGNAIRNQSNEEFELSFAVTETSDLRVRSTSLADGKLARQEWTWSDDGDKESVQAIVDQEIRRISS
Length1318
PositionHead
OrganismFusarium langsethiae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium.
Aromaticity0.08
Grand average of hydropathy-0.169
Instability index51.04
Isoelectric point5.51
Molecular weight147823.96
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05054
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.25|      15|     177|     511|     530|       1
---------------------------------------------------------------------------
  511-  525 (24.64/23.32)	RAVLTFEGVKSDSIF
  537-  551 (24.61/ 8.23)	MTLLPLKLVTSARIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.21|      37|      70|    1145|    1185|       2
---------------------------------------------------------------------------
 1145- 1185 (61.99/49.89)	PSNQG...PNQLAS..SQAMIKNMLNHIEFNIKltilPNITCTVRG
 1213- 1254 (57.21/36.85)	PYKEGypdPNALADylGTATSRLLVEHYLSNLS....PPWTRSIQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.80|      23|      24|     684|     706|       3
---------------------------------------------------------------------------
  684-  706 (41.58/32.30)	P...QRTPTNRAIMTLGGDSQPLSLR
  708-  733 (37.23/27.98)	PpvaDRKPRNIAEFITRVNAQPGGFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     360.16|      85|     416|     576|     661|       5
---------------------------------------------------------------------------
  576-  661 (141.23/96.15)	RRLWMQSRRAAGKRSKWQFT..SLSPHN.DVQAVFKSVPP.........TEISDIIDQLDPLGEVPILEDDLMPTMTADNPQSKLRRvRM.LQREGHRR
  886-  976 (98.51/61.67)	.RYWEDI..VAVQKSGWSITrvPMERHTlGVRFGFSEAAPeyrnslapmRRGSDGTVQLD.CGKLGGVSERVVVTYERDG.QITGRS...aLPAETAVD
  993- 1070 (120.42/77.21)	QELWHELTREA..RTLAAY...DVKP...DGSRLTCDIDP.........ESKSRIILELVPLGTYASSDDSLPDNHIAETISLSL...HI.LLGYAHRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     201.70|      43|     108|     305|     347|       7
---------------------------------------------------------------------------
  305-  347 (79.64/59.20)	WEFAFCIYTFGWLL.EKMAAIIEHGWAVHAQ.NLWAFLDITFGSI
  414-  458 (65.57/47.22)	WCFTGFLLALQWLVsASNDGDEEFSWYVVGKwMLWIWFGLDGEGI
  463-  499 (56.49/39.50)	R...FHI.IIGPAL...MIAFAFLGNTLFLT.ILIAMLTNTFSKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.30|      22|     408|     846|     867|       8
---------------------------------------------------------------------------
  846-  867 (35.80/24.83)	VKAQEQENIALGFTLMQTNKVR
 1257- 1278 (35.50/24.56)	IRNQSNEEFELSFAVTETSDLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.25|      24|      25|     737|     761|      11
---------------------------------------------------------------------------
  737-  761 (34.11/25.50)	EAKLKEEIAQENATNgDSQQKDVDM
  763-  786 (40.14/25.03)	EADEDDDEEDQDATR.DLQEVRMEM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05054 with Med17 domain of Kingdom Fungi
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