<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05051

Description Srb8-dna-directed rna polymerase ii holoenzyme and srb10 cdk subcomplex subunit
SequenceMTSRTPMGAHPRPPQRSVSSSSLPVQRPPPQRTLSHQQQFVPASPVRKDSSFIDLTADAGDATPNRYNTTPRRGGSRLRLELSHNASTGSLPTSESPQSLTPSRIPANSDPFQAMVGSPGLINSANSTSMPMPTRRPVALQLRLAPPIMTTAATLVKKDTRPKPYTVEVPSAAPRYFAANRPETTARNPVDPFSKGLNSGYADFFPWNGAHHEDEWSSEAITKGTWDKVNLNVPETSSAKLAIFPALKQKTGLNALSTIFMGVLTQRRHRGQINAPSTFKPPPRVTLTDTKREVWLKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKSVPVERAVWLAKCVGANEIRGLKRKGVNGAFVMGGELKWARDWTVFVEQFVDAVVTGFSEKDWKNRVTYAIRLASNLYSEQLLDRDHYLDWVVSGIENSLQSRIPMWLLIAQIYWKDLLRFRKYGRRLVFALLSHLHVIYNDPDQDLLVQLSSRLSTLLSSLVLSNPESFINPGAWPRYKTTLQSFLPTDHEPTQKSLHIINSRNSRLVVSSTASPPAGRSQLVKLLDAALKESSDDHLAATCWATSENKPLIMKTVVEWATSFHRPGLAKVYAAARLIRQWSQFRVNPTTPILETLDSISIEDKTRKNLIYHLVTELIRTGHFSVSQYMQWTIARGGYHSGAEIDADSGPCSSRLLVELPLHALSEKKRAERGNLLRRAGNYSIVEEEQDIANAIKFVRHSVGLPLPLGDPLLERKPVSLKRLLPRISSSSGALRSSVGAHLRDVLTSQFNHNQPSLPLTMYNSVRAIMETAEDYSMLSDILGACSKTADCDVLASVADTVHSNLQIFSALGSANDLFNVLIERLKSMNEEQGIVPRPLLASLSSLAQRMPGHEVIASHLRQELLQSDRSNVVDACSPVSDIVAAPTQHAENELAEDIEKQLSSGTRLDPPTMNKLFRRIIPALERGWEKTDDTRRVFATLLTRIRVFDAHHFDKLMTDWTSHVRSLPNRSPLVSLFPLLVSTGCLTMPIIMSTASPPSASFQNLSSDPSGNKFGPATYLQELLQLIIMSLPSGTGLSAEESYRFHTEQKCAKFEQSKGLLNLVRNALLEYSGLRNHANSPEFPLDNPACQESLLETLRTLVLIDSSAVSNALGIKSLPAEAVGLVRKVTTKLLIPGDSGDTQISFDHILQIANELTLPFCQLKLNLDLSLPQPNTNEGQDQGSSRFEVFAKAMDRAIEAGNIMWTSLLPCLSDDITQHLKSQAQSVFLELIPSSKAPERVDSGSRQSLRMAENLLEVVEAIISGQPPPKMAQLSLGMVEKLTDLWEIIAAGPHERPNCYVAVLQHWLPAMLRFVTLHSLSSEPPSAPLPTASATRPPIPPVHDTRARIILVLCGLLLELDTLSPAVVGSLPQQVFDIAILLVDALPEDLRANCAKAILLTSGGLPNQGTSSDPRLYYLFSSPPPSLSDNLMLSHREKAATPQSAVARGMGAQYGIGPAVQERLTPFVLRRWEVLSEPTPNVGENDTSLSLGLFEAIKLQ
Length1530
PositionKinase
OrganismFusarium langsethiae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium.
Aromaticity0.06
Grand average of hydropathy-0.214
Instability index51.11
Isoelectric point8.86
Molecular weight168631.99
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
DNA-directed 5'-3' RNA polymerase activity	GO:0003899	IEA:UniProtKB-KW
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05051
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.68|      33|      35|     378|     412|       1
---------------------------------------------------------------------------
  378-  412 (47.48/43.27)	QFVDAVVTGFsEKDWKNRVTYAIrLASNLYSEQLL
  416-  448 (61.20/44.48)	HYLDWVVSGI.ENSLQSRIPMWL.LIAQIYWKDLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     194.43|      65|      98|     806|     873|       2
---------------------------------------------------------------------------
  806-  873 (97.36/69.20)	SMLSDILGACSKTAdcDVLAS........VADTVHSNLQIFSALG..SANDLFNVLIERLKSMNEEQGiVPRPLLASL
  897-  971 (97.07/58.21)	SDRSNVVDACSPVS..DIVAAptqhaeneLAEDIEKQLSSGTRLDppTMNKLFRRIIPALERGWEKTD.DTRRVFATL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.54|      18|      19|     215|     232|       3
---------------------------------------------------------------------------
  215-  232 (33.79/24.22)	EWSSE..AITKGTWDKVNLN
  235-  254 (25.75/16.51)	ETSSAklAIFPALKQKTGLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     148.37|      50|     324|     140|     199|       4
---------------------------------------------------------------------------
  140-  199 (74.53/58.70)	LQLRLAPPIMTTAATLVKKDtrPKPYTveVPSAAPRYfaanrpETTARN..PVD..PFSKGL...NS
  476-  532 (73.84/37.38)	LLVQLSSRLSTLLSSLVLSN..PESFI..NPGAWPRY......KTTLQSflPTDhePTQKSLhiiNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.72|      53|     324|    1092|    1144|       5
---------------------------------------------------------------------------
 1092- 1144 (88.76/47.84)	NLVRNALLEYSGLRNHANS..PE....FPLDNPACQESLLETLRTLVLIDSSAVSNALG
 1423- 1481 (80.96/42.95)	NCAKAILLTSGGLPNQGTSsdPRlyylFSSPPPSLSDNLMLSHREKAATPQSAVARGMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.67|      33|     324|     984|    1036|       6
---------------------------------------------------------------------------
  549-  594 (46.08/13.53)	RSQLVKLLDAalkessddhLAAT.CWATsenkPLIMKTVVEWATSFH
 1000- 1033 (57.58/63.41)	RSPLVSLFPL.........LVSTgCLTM....PIIMSTASPPSASFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.58|      15|     328|     273|     298|       7
---------------------------------------------------------------------------
   27-   41 (29.36/ 9.50)	RPPPQRTLSHQQQFV
  280-  294 (27.22/16.75)	KPPPRVTLTDTKREV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.64|      29|     101|    1272|    1312|      10
---------------------------------------------------------------------------
 1280- 1310 (41.97/39.96)	RMAENLLEVVEaIISgQPPPKMAQ....LSLGMVE
 1493- 1525 (46.67/15.49)	RLTPFVLRRWE.VLS.EPTPNVGEndtsLSLGLFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.73|      21|      42|     295|     319|      12
---------------------------------------------------------------------------
  295-  319 (29.03/25.80)	WLKDlANPAISLRRLSRtipHGIRG
  338-  358 (38.70/20.55)	WLAK.CVGANEIRGLKR...KGVNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     176.28|      53|    1262|      54|     110|      13
---------------------------------------------------------------------------
   54-  110 (86.58/53.30)	DLTADAGDATPNRYNTTPRRG.GSRLRL....ELSHNASTGSLPTSespqSLTPSRIPANSD
 1317- 1374 (89.71/47.03)	EIIAAGPHERPNCYVAVLQHWlPAMLRFvtlhSLSSEPPSAPLPTA....SATRPPIPPVHD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05051 with Med12 domain of Kingdom Fungi
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