<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05049

Description Cyclin-dependent kinase 8
SequenceMDYEFKLKTDTDRTKVEDLFEFEGCKVGRGTYGHVYKARRKEGVPDSELKSRPDTKDFGLKQIEGTGLSMSACREIALLRELKHVNVITLIRVFLSHIDRKVWLLFDFAEHDLWHIIKFHRAAKANKKPVMVPKGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPLEKDWEDIKKMPEHPTLLKDFKRSNYANCSLTKYMDRHKIKPDSKAFNLLQKLLMMDPNKRITSEHSMQDAYFQEEPLPTQDIFAGCPIPYPKREFLTDDDTEEKTENKARQNQQQTQQNQQQQGNGDHNHGQNAKRVRLNGPHGAPEFHQHQSHAMTHQQPPGMVYSTAQPTQPSNFHQRF
Length453
PositionKinase
OrganismMelipona quadrifasciata
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Apoidea> Apidae> Melipona.
Aromaticity0.09
Grand average of hydropathy-0.685
Instability index41.17
Isoelectric point8.66
Molecular weight52627.54
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05049
No repeats found




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05049 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPYPKREFLTDDDTEEKTENKARQNQQQTQQNQQQQGNGDHNHGQNAKRVRLNGPHGAPEFHQHQSHAMTHQQPPGMVYSTAQPTQPSNFHQRF
360
453










Molecular Recognition Features






MoRF SequenceStartStop




1) AKRVRLN
406
412