<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05047

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMMGILYEMRPLKRPKLGPPDVYPQEPKQKEDELTSTNVKLGFATMPQMSEEFGTARHCNVTAAKVGAYFNAILAKKEELSTMPDTARKRQQINPKDNFWPVTARTKNGIEAWFKDLSGCKPLIALAKKAPNFNKKEEIFMMLCEYQVPMLRAAWFIKLSSAYTVAVSEAKIKKRQLPDPTTEWTGTLIKFLKDQLTKLQEYYHINNHTIIANNQPVTPNSSSQATGNMNEEHKLALKQWHYCIQLAKYMFEEGLLDRQELLQWILELLDKIKSSPSENGILKLLLPLALQYLEEFVQSELLARRLAYLCCRKLAHMCSNIETNGNPQSPSISKSDVNGGKDTVNSNQIQNPLTAAFNDYLSCPHHRDVIYSLSIIIQVITLECPTALVWNSVGEGKAPSVLNGSPLDYLSCPPTALPCPPVSITNPTIKQLKIAQKNIRARSQAAEGKWSCDKWQQSSAGITTTKVLAALDALDRHSFDRMDSTNSLDTLYAKIFTSPPKDNTNERDTKTEYNPQQDSAVVEILCEWAVSAERWGEHRAMAVAKLLEKRQSEVTGETNENDDKDSICSNGNPPVLPIFQSLLMKFLDMDAPVLDNTTTQSKVQFTNFFHLFSELIRHDVFSHDAYMCTLISRGDLIQGPAASKPGTPSNREPIDEDSLFTGIDLKPTKLEVSDHGRTMDYDDSKIDDDLDKLLQHIKEDQQNSMDAPDSPKEDALAGHGTQEGLDSKMPSSHSRHLLYTRHFPLPQDETCSQHDCNQRHVLLYGVGRVRDDARHIVKKMTKEVCKLFGKKFSIDVAEGGKVKKHSRNEFNFEAITLKFQNLSYFDQHVVTWQCATQVIEMLNTFALAGSSYLPVQEHVAFLFDLMELALNIYGLIDVCIQILKELPEVETQLGLRNSQLVRSYTTSLSLYVVGVLRRYHCCLLLSPEQTTAVFDLLCKVVKHVSNPSDCSSAERCVLAHLYDLYSSCSLLKTKPHGVEAFSNAYPKIRTALYSTLQPTTSSHVYNSQFMVDVFTSPRRGGKIEPQWARQLNETPANRYSFVCNAIVAVCSETDNDKLNDIAITCAELTACCNALNAEWLGVLMALCCSSNSSAFYIDVLNQVDVQDLSIHNSLAVFTSILIARHCFSLEDFVVHIALPSLVKACNEGRGDADMEAEAGARLTCHLLLRLFKTVECPQPALYSVSTSPHPLPNGNSRGYSIKLSCDRHLLAAAHNNIRVGPVLAVLKAILVVADATAGGPSELSISHILGTSDILGGGDDLGLDLAISSSSSSAGMTTENVKGLSDFAQHVLRQICSQEWVLERCLQNPEELCHPDMLLDNMLTPRQAQRLLHMICYPEISTDAFIDQKTHITNILENLEQWSLRMSWLDLQLMYKQFPPGSSDLSQWLDTVAKAAIDVFQLNTMSSKPDKRSGSIWLVAPLVSKLPSAVQGRVLKVAGQVLESGNWSKTATGRERSRSKSPSLFNHQPFLSLVLTCLKGQDDQREGLLMSLHSQLSQFLNISKEEKNFVTEDPKTREVLQDALQLRFSLVGGVFDTIQRNTTATTDWAILLVQLVSYGVIDLNNNSGLFTTVIDMLATLIHSTLVSDSQSEKDENKKHYQNLMKKLKKELGDRNSPSIRYVRQLLPLPKLTMEVITCEPVGCLTDTKGNKIAGFDSIDKKQGLQVCDSQRVSAWEVLEGHKSPAPISWAWFRAVKLERKPLTYQNAHKLLRYHTHSQIRPPSHYLDPPPLPPEDLEPDKKESEPGKADTPMSIDSPGRVTGSVGSSGISNTITNGKGKAMKTRRHRRNKGATTPTTPVSQQIQQPPSQLQQMPFGNQQVPVSQQPGMFTNQPPQHQQPWYTNQQTHAPAQQYAYGQQLPPTPVGPRYDRPGMNNQSKQALSHMLRLRLPSNQLISSQQQPSAAPVAGPGAFQGMQRQFIRHQLRAQHGAPNINPQQGMFASQQQQQQPQQQGIYTGMQQGGYILLFYCFFYCYQQMMGPQRAQEYIPQQRMQPGATRPPYLQAPNVTMNTMGPMGGGVQSQPAPPYRQTSGKPGTVGVTGVGTTNVGLQQNQQFQQQQTISQQRMRQMLAIQQQQQQVQQQQQAQQQQQQQQQGNAGGQQPTPQLVTHLQRHLSQPPQHYQHQPPPY
Length2127
PositionKinase
OrganismMelipona quadrifasciata
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Apoidea> Apidae> Melipona.
Aromaticity0.07
Grand average of hydropathy-0.434
Instability index51.89
Isoelectric point7.62
Molecular weight237769.04
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05047
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     391.41|      41|      42|    1859|    1899|       1
---------------------------------------------------------------------------
 1793- 1833 (49.10/18.40)	T.PT.TP.........................VSQQI...QQPPSQLQ...............Q.MPF.......G..NQQVPVSQQpgmftnqPP
 1834- 1860 (49.60/18.65)	Q.HQ.QPWY........................TNQQ...THA...............................PA..QQYAYGQQL.......PP
 1861- 1901 (67.14/27.75)	T.PV.GPRYDRPG...................MNNQS...KQALSHML...............R.LRL......PS..NQLISSQQQ.......PS
 1902- 1948 (43.64/15.57)	AaPVaGP.GAFQG...................MQ......RQFIRHQL...............R.AQHgapninPQ..QGMFASQQQ.....qqQP
 1949- 1993 (37.31/12.28)	Q.QQ.GI.Y..TG...................MQQ.............ggyillfycffycyqQ.MMG......PQraQEYIPQQRM.......QP
 1994- 2025 (48.78/18.23)	G.AT.RPPY.LQA.............................PNVTMN...............T.M.G......PM..GGGVQSQPA.......PP
 2028- 2086 (38.18/12.74)	Q.TS.G....KPGtvgvtgvgttnvglqqnqqFQQQQtisQQRMRQML...............A.IQ.......QQ..QQQVQQQQQ......aQQ
 2087- 2125 (57.66/22.83)	Q.QQ.QQQQGNAG...................GQQPT...PQLVTHLQ...............RhLSQ......PP..QH..Y.QHQ.......PP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.31|      22|      27|     822|     846|       2
---------------------------------------------------------------------------
  822-  846 (34.61/40.24)	SYF..DQHVVtwqCATQVIEM.LNTFAL
  850-  874 (29.70/21.87)	SYLpvQEHVA...FLFDLMELaLNIYGL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.55|      16|      18|    1181|    1196|       3
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 1181- 1196 (31.34/15.52)	YSV..STSPHPL..PNGNSR
 1198- 1217 (21.21/ 8.29)	YSIklSCDRHLLaaAHNNIR
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.79|      33|     220|     327|     360|       4
---------------------------------------------------------------------------
  327-  360 (52.57/40.45)	QSPSISKSDVNGGKDTVNSNQiQNPLTAAFNDYL
  550-  582 (58.22/40.13)	QSEVTGETNENDDKDSICSNG.NPPVLPIFQSLL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.79|      31|     244|     471|     549|       5
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  471-  503 (54.53/47.22)	DALDRH....SFD.RMDSTNSLDTLYAKIFtsP.PKDNT
  713-  749 (47.26/10.51)	DALAGHgtqeGLDsKMPSSHSRHLLYTRHF..PlPQDET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.24|      37|      39|      79|     117|       6
---------------------------------------------------------------------------
   81-  117 (66.83/50.80)	TMPDTARKRQQINPKDNFWPVTARTKNGI..EAWFKDLS
  121-  159 (60.41/38.58)	PLIALAKKAPNFNKKEEIFMMLCEYQVPMlrAAWFIKLS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     344.01|     114|     220|    1219|    1339|       7
---------------------------------------------------------------------------
 1219- 1339 (181.46/114.76)	GPVLAVLKAILVVAD..ATAGG........PSELSISHILG.TSDILGGGDDL..GLDLAISSSSSSAGMTTENVKglsDFaqhVLRQICSQEwVLERCLQNPEELCHP..DMLLDNML.TPRQAQRLLHMICYPEI
 1431- 1560 (162.55/86.71)	GRVLKVAGQVLESGNwsKTATGrersrsksPSLFNHQPFLSlVLTCLKGQDDQreGLLMSLHSQLSQFLNISKEEK...NF...VTEDPKTRE.VLQDALQLRFSLVGGvfDTIQRNTTaTTDWAILLVQLVSYGVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.36|      15|      47|     918|     933|       8
---------------------------------------------------------------------------
  918-  933 (26.15/20.82)	YHCCLLL..SPEQTTAvF
  964-  980 (24.22/13.62)	YSSCSLLktKPHGVEA.F
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.83|      15|      15|     277|     291|       9
---------------------------------------------------------------------------
  277-  291 (24.59/15.01)	ENGILKLLLPLALQY
  293-  307 (24.24/14.69)	EEFVQSELLARRLAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.69|      16|      19|    1042|    1057|      10
---------------------------------------------------------------------------
 1042- 1057 (27.65/21.62)	CNAIVAVCSETDNDKL
 1064- 1079 (30.04/24.29)	CAELTACCNALNAEWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.45|      10|      32|     381|     390|      14
---------------------------------------------------------------------------
  381-  390 (20.21/ 9.77)	LECPTALVWN
  416-  425 (20.23/ 9.78)	LPCPPVSITN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.38|      11|      24|     673|     683|      15
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  673-  683 (22.20/14.86)	DHGRTMDYDDS
  699-  709 (21.17/13.77)	DQQNSMDAPDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.37|      10|      32|    1379|    1388|      20
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 1379- 1388 (19.73/11.00)	PGSSDLSQWL
 1408- 1417 (18.63/ 9.93)	PDKRSGSIWL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05047 with Med12 domain of Kingdom Metazoa
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