<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05037

Description Uncharacterized protein
SequenceMIPHSSAGGQSWGHPLRTFNGGPGRVDNAQMLGQYDQPDRSASLPQPPIRQPVVVDLTAGGPESQDREPPPKRPRLDVPSASHTSDTAATVGETRSTPGSAISRPAVSWRGRPAWSFQAVVSEIPSNENRGDGAVGSKPPSPPPLPAQPWMNNFVAEPEGSGVVKSRESSPVGAVQTTPYRIETPSVAPVYKGQKPADFAPWTGNHPEDVLSEQTAKQGYYDRTQVSQNESNTARPALYAQLKNRTGLQMLSSVFAAALEKRQSHNTINAPSTFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKILLDQCLGKWIPIARAVWLAKCVGANEIRAFKRKGTSGALAVGLEAKWVRDWTTNVQQFAEGVFAAPKSSDWKAKMTYAVGLTARLFSENLLDHDHFLEWFLSSFEAASIGTIPVWLLMLGIYWNSIMRYRRRGRRLAELLLEKVRQATEAKLTQLQPLIDRLSRFIKKLVLDHTSSMILPNSWETYQQQVSSALDLGNEAEKALFQSLVERNVRVQRSRHSKQTTQRSPHQRIVRLLDSIRSAQDLSSVFGYLDAFDDKAVLVSKLLEWLSTPFRHGLCRVYIGVRLLRKLKLAGVDIDSHILAFLSRGQNKQKLNMDQIYHVVSELVRSQTFSVGRYLQWLMARGVTGSPSAGERKAKDLPTDIGLIAQLPVARLPEHVGNLRSTLLTRTGLSTSEENAAIDSVKEIISQRLPGIFGVHESASMVLDSLPPNLPWAVKAEVGQWLRRAIAEHNRSVESTNRGAFPVGVTSVVSALTPAEFYTVRDTLESFGDISMLADVLMFASSCGDSTVLASVADTTNCHFDSLCMIGATTDLFRRLIDAYAGIKRFGMPGLDLIFSLIELGLRIPSDLNTVSILRQDLSRMENKAIMAASSPVSDHIPDGFGGIDPFFREKLDQLLQSGNVMDEPTLDAIFNTLIKHLESDDGHANLSANDTCRYLAQLRSFHPKHFDSILARWVCGHLRSPERTILLRILPPLIGVGCVTIRAFLALAKKLTLSKPATVPNAAQLPVDLVQLLVSGDEDSKSFDLVSYRFQLAQQEFLNKNSEEALKIVCDAASCNAGSSSTGHTEMERSIVMLLRDLFVRHPECAAQNGMQKLIDQYPAALSIVQKALDLLLGIESQSDGSSVLSKVEKLACMTDDFSLPFCQLKLQVLFHADSGAEDRTNIVDAMFKTAVSDCRAHRLHWVDLVALMSPDAVRQIRERAEKEFFSIPLLEEPIDDIPDSPDKLGSLETAKMYLTIIEELASSIPDSGAPSVAPVLVEKMDFLLHKIITMHNNNTLAKGVGNTDRSKLERALAFWFSALLRIIVLHRSAFSQPPPALKINPLHEQLRLLTSIFCIALSRLPGDVLRLFPAADYFPHPTPAEGFRPCPGILLQTHALDVAASLIDIFPDEVRHQCARFLKEKCPSFIPFQNDSRFLYLLGPISDQYPANAHQVSAPSPAASGSTPTPTPSIFSISGSSTAQQSVTAASGPSTAPPDSNSMTNRLRLQHRGRVVGPYPVRPWELLEDAAPFLGVNDTAVNLGFFDARRVRA
Length1571
PositionKinase
OrganismPenicillium nordicum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.179
Instability index48.49
Isoelectric point8.56
Molecular weight173039.84
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05037
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.69|      59|      71|    1116|    1183|       1
---------------------------------------------------------------------------
 1116- 1183 (79.75/77.54)	LRDLFvrHPECAAQNgMQKLID.QYPAALSIVqKALDL....LLGIESQSDGSSVLSKVEKlacmtDDFSLPF
 1188- 1251 (89.95/57.85)	LQVLF..HADSGAED.RTNIVDaMFKTAVSDC.RAHRLhwvdLVALMSPDAVRQIRERAEK.....EFFSIPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.45|      11|      15|     806|     816|       2
---------------------------------------------------------------------------
  806-  816 (20.29/13.04)	SFGDISMLADV
  822-  832 (20.16/12.91)	SCGDSTVLASV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.31|      37|      74|     847|     887|       3
---------------------------------------------------------------------------
  847-  887 (56.54/45.50)	GATTDLFRRLIDA..YAGiKRFGMPGLDLIF.SLIElglRIPSD
  922-  961 (57.77/34.40)	GGIDPFFREKLDQllQSG.NVMDEPTLDAIFnTLIK...HLESD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.19|      18|      75|      60|      77|       4
---------------------------------------------------------------------------
   60-   77 (35.48/16.07)	GGPESQDREPP..PKRPRLD
  133-  152 (32.71/14.24)	GAVGSKPPSPPplPAQPWMN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     362.98|     101|     279|     301|     409|       5
---------------------------------------------------------------------------
  301-  409 (156.59/150.63)	LRRLSRTIPHGIrGKILLdqclGkwIPIARAVWLAKcVGA...NEIRAFKRKGT.SGALAV....GLEAKWVRDWTTNVQQF.....AEGVFAAPKSSDWKAK.MTYAVGLTARL..FSENL.LDH
  430-  489 (64.90/41.53)	...............................VWLLM.LGI.ywNSIMRYRRRGR.R..LAE....LLLEK.VRQATE........................AK.LTQLQPLIDRLsrFIKKLvLDH
  583-  695 (141.50/106.83)	LEWLSTPFRHGL.CRVYI....G..VRLLRKLKLA...GVdidSHILAFLSRGQnKQKLNMdqiyHVVSELVRSQTFSVGRYlqwlmARGVTGSPSAGERKAKdLPTDIGLIAQL..PVARL.PEH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.85|      43|     279|     225|     268|       6
---------------------------------------------------------------------------
  225-  268 (67.18/45.44)	QVSQ..NESNTARPALYAQLKNRtGLQMLSSVFAAALEKRQSHNTI
  505-  549 (64.67/39.44)	QVSSalDLGNEAEKALFQSLVER.NVRVQRSRHSKQTTQRSPHQRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.62|      34|    1104|     185|     223|       7
---------------------------------------------------------------------------
  185-  223 (56.02/54.35)	PSVAPVYkgQKPADF..APWTGNHPEDVLSEQTakqGYYDR
 1292- 1327 (56.61/39.15)	PSVAPVL..VEKMDFllHKIITMHNNNTLAKGV...GNTDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.83|      11|      76|    1399|    1409|       9
---------------------------------------------------------------------------
 1399- 1409 (25.23/12.83)	PTP.AEGFRPCP
 1477- 1488 (18.59/ 7.32)	PSPaASGSTPTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.91|      12|      15|    1429|    1440|      10
---------------------------------------------------------------------------
 1429- 1440 (23.84/13.95)	PDEVRHQC.ARFL
 1445- 1457 (19.07/ 9.61)	PSFIPFQNdSRFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.86|      12|      17|     978|     993|      11
---------------------------------------------------------------------------
  978-  993 (12.60/22.99)	QLRSfhPKHfdSILAR
  998- 1009 (22.26/13.74)	HLRS..PER..TILLR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05037 with Med12 domain of Kingdom Fungi
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