<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05034

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMEKGGPDGARTDHPREAALNGTGGAKSIDRSRSAASQKGKVTPVSNEPGGVNGQDGGSRSRQQSADRSLRMNDLPDEIIHITQGFVPLQLFLTRLAQVTHNSIQDKMAELAKMPVPASATNGNSSHAVTAPDDASAENIRKKAALLHFAHDMHSKWVKALVIMEWSRKAAKVSKLIDLKFLLDQQRIVFDAALDHAINVKRDLTYARMPSPDLKTALQTLSTGTAPYMPDLQYIEPPPLTPDVQLKWINELNTLLSLRLNLEDYEKIPFHFRTYEISSGRVTFKVPGEFEVDLTIADEDFEKQFWFLDFRYAFAPAASSLPESLRGHLEGCVNDALAKDGLTGCYQFLHEFVLTSKINELKRQALQLSRSSWFGSLKVEPLNRALAVQYWTSRNQSTGLKSWILVAVHSRRKQDGRHDPKTSSRLVAKWYRDNKEVKDVELELDASHLSAETLLKTVIGRHIEHVLASIYDRLLTAPRFQKREAGMTLRISETDPGASALSVQVGCRGTVSLMIEHTTGVFSVKPNSKFSFHHELQLNNGKNPAEDGMNCLENVRCGIAEDELVRSATSMGWFVRKGVMSAEELRAKTKIRDWTRVIWLQRDGLGPSWFVVVILGLGGDEWWLLESHAGEPSNWPRFQSRLPLNKGYPDLAESFWTNLTLFTTGTITQAVDMRELYHRQIQSRTNDSLNLTLPQEVRLPSIEVALSELLPAIGVGDSDKETILPPSDGTEMQDTSEVLNLLNRDSETAPSKKQCWAHNNVTIRFQGVRNLVRPSPSEGTAGSNEMICITDAVIRVRRPSKFTTLNKTVDHDVSYCAQKGEFTLRMRRSATQPVIAALLPRIKAIDRFVNFLEAMHGPNGAITSESATLKRVTFNYCKPSVVQQGEEMPPSSRRWRVTMDLAKDDINIEMEPGNPHLRVIDLVKRMVNCEGGIGALMTWLPSSLPALDAINKIESQWDELEARGLGQFRFSMWTATSMHLAFTIFGPNGTDTASPTRLSLEAQIKIRRGEAWWNIWRPDKDAAGALPDDELAKALKPIWGGRGKDWLGLSTSAAGRLGDGVSNMLSAIDEAVRSLAPAPGAEVAKMGVGATAGPFPPRIGASGNGDYAPAPVVVLD
Length1115
PositionTail
OrganismEscovopsis weberi
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Escovopsis.
Aromaticity0.07
Grand average of hydropathy-0.346
Instability index45.71
Isoelectric point7.38
Molecular weight123555.16
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05034
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.80|      20|      23|     886|     908|       1
---------------------------------------------------------------------------
  887-  907 (32.97/23.46)	MPPSSRRWRVtMDLAKDDINI
  909-  928 (37.83/22.13)	MEPGNPHLRV.IDLVKRMVNC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.66|      19|      23|     555|     577|       2
---------------------------------------------------------------------------
  559-  577 (34.18/28.57)	AEDEL.....VRSATSMGWFVRKG
  580-  603 (29.48/12.40)	SAEELraktkIRDWTRVIWLQRDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.20|      30|      33|     981|    1011|       3
---------------------------------------------------------------------------
  981- 1011 (49.42/29.06)	FTIFGPNgTDTAS..PTRLSLEAQIKI..RRGEAW
 1012- 1045 (47.79/23.62)	WNIWRPD.KDAAGalPDDELAKALKPIwgGRGKDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.05|      13|      27|     202|     214|       4
---------------------------------------------------------------------------
  202-  214 (25.02/14.10)	DLTYARMP..SPDLK
  230-  244 (21.04/10.69)	DLQYIEPPplTPDVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.10|      12|      24|      20|      33|       5
---------------------------------------------------------------------------
    5-   16 (23.51/ 8.01)	GPDGART.DHPRE
   21-   33 (17.59/13.16)	GTGGAKSiDRSRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.88|       9|      34|     262|     271|       6
---------------------------------------------------------------------------
  262-  271 (15.59/14.98)	EDYEKiPFHF
  298-  306 (20.29/13.60)	EDFEK.QFWF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.54|      16|      23|     753|     774|       7
---------------------------------------------------------------------------
  753-  774 (23.09/27.67)	QCWAHNN.......VTIRfqgVRnlvRPS
  777-  799 (22.44/10.40)	EGTAGSNemicitdAVIR...VR...RPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.76|      18|      23|     341|     362|       8
---------------------------------------------------------------------------
  341-  362 (24.26/25.20)	LtgcyQFLHEFVLTS.KINELKR
  365-  383 (27.50/15.35)	L....QLSRSSWFGSlKVEPLNR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.20|      25|      34|     806|     830|      10
---------------------------------------------------------------------------
  806-  830 (44.34/31.64)	KTVDHDVSYC.AQKGEFTLRMRRSAT
  842-  867 (38.86/26.78)	KAIDRFVNFLeAMHGPNGAITSESAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.15|      16|      32|      72|      87|      12
---------------------------------------------------------------------------
   72-   87 (28.65/18.93)	NDLPDEIIHITQGFVP
  101-  116 (27.50/17.88)	NSIQDKMAELAKMPVP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05034 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DKMAELAKMPVPASATNGNSSHAVTAPDDA
2) MEKGGPDGARTDHPREAALNGTGGAKSIDRSRSAASQKGKVTPVSNEPGGVNGQDGGSRSRQQSADRSLRMND
105
1
134
73










Molecular Recognition Features






MoRF SequenceStartStop




1) ARTDHPREAALNGTGGAKSIDRSRS
9
33