<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05030

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMTSRTPLGVHPRQPPRSLGSSSLSGQRHPPHQRAVLTQPFFPASPARKEPYSDPAADFYQALDPLQARHAAAAAAPAPAPAPAAAAITTNPRRAGSKLRLELSHPTEPPAPLTSALSSTSRPPSPSRIVSLSSDLPNNQPGASPSPSRALRDPDNTPLPMPRRRVPQPPCTTRASAAQKKPTSAPPPPLSSKKDVRPKAWAIEVPTDAPRLPSHNKPKFPPRDPFSRGLFSGSADFFPWNGNHYEDDWSVEAAQKGTWDRGTQTETSSARMALSPAIKQKSGLTALSTIFMGVLNQRRYRGQVTAPSTFKPPPRVTLTDTKREVWMKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKNVPTERAVWLTKCVGANEIRAFKRKGASGAFAMGGELKWMRDWTVFVEQFVDAAASAFVEPDWKTRITYAFVCPSMWPKFRLAMEASLPADDNAARCAYAHVELRNSRVSVSNTVMPLAGGQRLVRLLDSTLQNQIDRDLSAKCWATGDDKLQIVRTTLEWATSFHRPGRAKVYVAVNLLRSWSAVTRINMTSVILEHLDSISPRDETRKQMAYRLVTELVRTGHFSVSQYIQWLIARGSCHSAADVCSTSSPCATRLLVNLPLRNLTEEQQRDRGNILRRAANYSVAEEADDICSAVRVVDQTLALVSTLEAPLATSKPVPLRRLVRKISDSSMALQSSVASHLRDTLTRKTWNEKAAALTITLDLFVSIRAILEAVQDFSMLLEVVKVCAQATSPEVLAACVDTANFNLLVFSAIGGVDDLFNLFMTRLKAVARERGVGARPLLAALSRLAQRLPGREDIAKQLTCDLTQSDRSNAIDACSPVSDNTVGPVQTGADGEVSDQVDRLLASGNSIDHPTMNRLFRYILSRLDAGWAKLDDGRRVYASLLSRLRIFDPQHFDKLMGDWVNSYVRCVKERQPLAAIFPILVITHCLPISALVQSASPPPPPSSPAPSDANTGFGARTYYQELLQLAVTKLPGGAGLTLEEEYRFSICQQLARSNCPKAFLLLLRNAVLEFTGTGSMPSPSSGLDTASFQDQILESLRQLIVTNLGMVMELLSIKSMPLEAAKFVHEMMSKLLTPKELEGPSPSFDQVLGSVNELTMPFCQIKLNLDLSLARLSSGASGASGGGGGEQGPSQFELFVKAMDRSLEAQNMAWTSMLPCLTEDITQHLKNQARGRFLELVPSIKSPKLLEMATNANGIRLAKNLLAVVQAIIAGQPPPKSAQLSQMLVEKLGELVEIVATRDHEKAQLRRVILDEWLPAFLRFITLHGLCAEPLNTSLNLSIQGKTIIPTNHEARGRIILILCRLLLELDSLPAGPAHPTADLAQHVFDIATLLVDALPEELRVNSAKNALLLPGVIPSVNTSSDPRLYYIFSMLRPSPKDHFMIAHRDKSSVSQTATSRGMGAMFGIGPLSQPRYSPFVLRRWEMLSEPTPNVGENDTSLSLSMFAAIKI
Length1475
PositionKinase
OrganismEscovopsis weberi
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Escovopsis.
Aromaticity0.06
Grand average of hydropathy-0.181
Instability index46.10
Isoelectric point9.42
Molecular weight161430.73
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05030
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     319.85|     103|     567|     583|     691|       1
---------------------------------------------------------------------------
  583-  691 (159.55/127.17)	GHFSVSQYIQWLIARGSCHSAADVCSTSS.PCATRLLVNlPLRNlteeQQRDRG.NILRRAANYSVAEEADDiCSAVRVVDQTLALVSTLEAPLATSKPVPLRR.LVRKISD
 1152- 1257 (160.30/109.92)	GEQGPSQFELFVKAMDRSLEAQNMAWTSMlPCLTEDITQ.HLKN....QARGRFlELVPSIKSPKLLEMATN.ANGIRLAKNLLAVVQAIIAGQPPPKSAQLSQmLVEKLGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.92|      24|     566|     222|     275|       2
---------------------------------------------------------------------------
  245-  274 (32.66/60.78)	EDdwsveAAQKGTWDRgTQTETSSARMALS
  819-  842 (43.26/12.72)	ED.....IAKQLTCDL.TQSDRSNAIDACS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     129.97|      25|      26|      76|     100|       3
---------------------------------------------------------------------------
   24-   47 (28.75/ 9.45)	SGQRHPPHQRAVLT.....QPFFPASPAR.
   76-  100 (40.35/16.34)	PAPAPAPAAAAITT.....NPRRAGSKLRL
  105-  133 (27.08/ 8.46)	PTEPPAPLTSALSStsrppSPSRIVS.LSS
  134-  158 (33.79/12.44)	DLPNNQPGASPSPS.....RALRDPDNTPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.80|      20|     180|     798|     817|       5
---------------------------------------------------------------------------
  798-  817 (35.71/24.36)	GVGARPLLAALSRLA.QRLPG
  979-  999 (33.09/21.93)	GFGARTYYQELLQLAvTKLPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     197.07|      66|     777|     505|     579|       6
---------------------------------------------------------------------------
  505-  579 (98.49/94.92)	ATGD.DKLQIVRTTL.EWATSFHRpgrakvYVAVNLLRSWSAVTRINMtSVilEHLDSISPRDETRKQMAY...RLVTEL
 1263- 1333 (98.57/69.73)	ATRDhEKAQLRRVILdEWLPAFLR......FITLHGLCAEPLNTSLNL.SI..QGKTIIPTNHEARGRIILilcRLLLEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.34|      10|     754|     385|     394|      10
---------------------------------------------------------------------------
  385-  394 (20.79/12.90)	GASGAFAMGG
 1142- 1151 (20.55/12.66)	GASGASGGGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.12|      18|     177|      48|      69|      11
---------------------------------------------------------------------------
   48-   69 (31.05/21.41)	KEPYSDP........AADFYqaldPLQARH
  218-  243 (33.07/14.70)	KFPPRDPfsrglfsgSADFF....PWNGNH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05030 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MTSRTPLGVHPRQPPRSLGSSSLSGQRHPPHQRAVLTQPFFPASPARKEPYSDPAADFYQALDPLQARHAAAAAAPAPAPAPAAAAITTNPRRAGSKLRLELSHPTEPPAPLTSALSSTSRPPSPSRIVSLSSDLPNNQPGASPSPSRALRDPDNTPLPMPRRRVPQPPCTTRASAAQKKPTSAPPPPLSSKKDVRPKAWAIEVPTDAPRLPSHNKPKFPPRDPFSR
1
227










Molecular Recognition Features






MoRF SequenceStartStop




1) APAAAAITT
2) ARKEPYSDPAADFYQALDPLQARHAAAAAAPAP
3) KKDVRPKAWAI
4) LYYIF
5) SKLRLELS
81
46
192
1392
96
89
78
202
1396
103