<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05026

Description Kinase-like protein
SequenceMPTSASASAVMHAYRAHKASMRKHVMHKYRILGFLNSGTYGRVYKAEEWRRTDPSAPRVYAIKKFKLDKEDDVTTFRGISQSAIREIALNKELQHENIVWLREVMLEDNSIFLVYEFVDHDFLQIIHHHLTVLRTSISGAVIKSLMWQLLNGIKYLHENWVMHRDLKPANILMNARGVVKIGDLGLARLYADPLISLYTSDMVVVTIWYRAPELLLGARHYTPAIDLWATGCIWGELMALRPMFKGEEARMNPKTKVIPLQSNQLGKIVDVLGMPTADRWPKINAMPDYAAWIATRRAEMVPKMLYQWYIDRSGTSSGFDLFDKLLQYDPDRRITAAEALQHPWFSEAPLPQSIVCASVASLTIEIGVGLVSGGVFFLFMGIVLFFDATLLALGNILFVSGIALLIGPQKTLLFFARKQKMRGTICFFTGMALVFLHWSIIGIVIETVGFLNLFGDFFPVILTFLRQVPGVGHLLTLPGVAQVMDQLAGARRSAV
Length495
PositionKinase
OrganismMalassezia pachydermatis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Malasseziomycetes> Malasseziales> Malasseziaceae> Malassezia.
Aromaticity0.11
Grand average of hydropathy0.226
Instability index41.69
Isoelectric point9.34
Molecular weight55853.99
Publications









Function






Annotated function


GO - Cellular Component
euchromatin	GO:0000791	IEA:EnsemblFungi
Golgi membrane	GO:0000139	IEA:UniProtKB-SubCell
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IEA:EnsemblFungi

GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi
vesicle-mediated transport	GO:0016192	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05026
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.41|      18|      19|      53|      70|       1
---------------------------------------------------------------------------
   53-   70 (31.04/20.36)	DPSAPR...VYAIKKFKLDKE
   72-   92 (23.37/13.76)	DVTTFRgisQSAIREIALNKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.99|      16|      20|     299|     315|       3
---------------------------------------------------------------------------
  299-  315 (26.90/21.91)	EMVPKMLyQWYIDRSGT
  320-  335 (29.09/17.89)	DLFDKLL.QYDPDRRIT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.57|      11|      27|     394|     404|       4
---------------------------------------------------------------------------
  394-  404 (19.89/11.69)	GNILFVSGIAL
  423-  433 (22.68/14.25)	GTICFFTGMAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.87|      21|      27|     183|     203|       7
---------------------------------------------------------------------------
  183-  203 (34.98/24.37)	DLGLARLYADPLISLYTSDMV
  213-  233 (37.89/27.04)	ELLLGARHYTPAIDLWATGCI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.86|      13|      20|     458|     470|       9
---------------------------------------------------------------------------
  458-  470 (22.89/14.92)	FPVILTFLRQVPG
  477-  489 (21.97/14.05)	LPGVAQVMDQLAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.39|      20|      26|     128|     153|      10
---------------------------------------------------------------------------
  128-  153 (26.84/28.04)	HHLTVLRTSISGAVIkslmwqLLN..GI
  157-  178 (32.54/18.21)	HENWVMHRDLKPANI......LMNarGV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05026 with CDK8 domain of Kingdom Fungi
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