<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05023

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMETSEYETNTLSINNIASIAFRIYEPSTDQSHSFQSSALEIQSTLRDQGKLVSYDAERGGIWIFQITNKEGASKAVSFGSGVSLEACGCTLGMVEEGTLEPAALQKNRIPSNTTQNAPTNASATTSPAEPHQRNPLISPTQTAGTQAEGGVQLPAQPVDTRTTQPVPKIIYEQFIIAVISSITFAFCSQSMAVPLNYRTVLIPPLQADTNEHEKVSLQTDPVIGTFKTYLTTTGSLVVSLYFSYCQNLATVEDVLSGDSSSPSGSILAAPYGVFATKSSFSNGDADRSLAQTPNTQALSVRSVPDAHDSLWKHSCLKALEYCGLNPSNFKAGLWVNLLITKPTLQDADGEQKRLRATVPWPGALCFRKKLLEVSTTHRVGDTILSGHEECHDPLGDARGWFAGTSEREERVSKRKAERAHAAPKEVNGANLQAQSLNGQSPLSVRRPSTAAAGVMYPTPPDAIQQHLGVTPSIDGATSSPNNAPPTLAVVDTDITMPTVTPMADVDHDGWEGGHEQKRERSDSNLLGDTEDIMNDMGGDVFGDHDVTEDDFNFFDGPDSNDMDLDMSDLQPISHPPPPQAILPQTIPPQAMPPPMITQPQPQKIIEPPPEIKPKPKTHEPVFAKPELKHARSSLNDELNHKVKTERSNSNKRGSSPFDPDTVFKRVKASLASPMQESFTFQAPLRRKSSIFEKVEFDPKIPLINKKYEHGGAFDFSKDQGSGELKRDTEGLSRDEYLERQGKLKPDSKTLPGVSLIRTLTGADGSANHTNAQKSNGNASFSEDSDVDSEADDLSSLSGGPVSPIKSSVKRTVVDDDALSQATTSREAELMDDATEEQLAIELPKLSKTESPEMPLHRFFSDPEPLNAEVGLSNHDFVEVAQIVTEQAATGRLDIGIDHKSESSVALATMRGHELNVARSSLQLLHNVIPSNLGSATAVRLKGLLEILDLPLAGQPNRLQPRPIPGRDTNVEQLRANNLYQIPVPHLEVRRSETKLSVLPSSVSFWEGLGLSPSWGAKDITAVCIFPGWKGMSDHVGSFIGRLKSVYESLKLGTFNNLALSGDWDDGILPYEVDRISTSPDATVTGHGSSLVESMEVLRSSLSELKSKDKNLVIYFVYSPDNPASIIEACTAFYRFFDEYSDLLAARRESPQNELVLQLVSSNLISSTTSLVVPTPAEMIKLCAETYDRCTLFLDAEYGGPTPAPAVMLEQPPPRMIDFKLTTSPSQSLMHENSCIHVGYAESLDGRWITAAWTDNRGQRQATASYSITRSRTPDRSPFQHKAAIITEIWATTLTMISIWKVHWRVIITRSGPMDQKEVEWWQAASTLDDKYSFTMVLMSVDTSPSLQLVPPVVKIPHAATSAFYSTPVSTPQANIVSPEQTTTPATPMRETSTLAATPGAESATEPDADSFLIDATDQTWGAIAGHRFGNSTTLLEMRPALASGYLIKRTGIKLEDPPVVMEVNLVHTEATPRAYEPLLREMLSYFRGLGTLARARGVTDREMDVRPWHIAVAEKGVRALHLLL
Length1524
PositionKinase
OrganismFusarium langsethiae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium.
Aromaticity0.06
Grand average of hydropathy-0.378
Instability index48.36
Isoelectric point5.21
Molecular weight166176.73
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05023
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     171.50|      57|     239|     402|     460|       1
---------------------------------------------------------------------------
  402-  460 (94.56/75.37)	AGTSEREERVSKRKAERAH.....AAP.......KEVNG..ANLQAQSLNGQSPLsvRRPSTAAAGVMY.PTPP
  630-  701 (76.93/54.29)	ARSSLNDELNHKVKTERSNsnkrgSSPfdpdtvfKRVKAslASPMQESFTFQAPL..RRKSSIFEKVEFdPKIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.22|      23|     226|     558|     608|       2
---------------------------------------------------------------------------
  576-  599 (42.34/44.16)	PPPQAILPQTiPPQAMPPPMITQP
 1202- 1224 (42.88/ 6.26)	PAPAVMLEQP.PPRMIDFKLTTSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.96|      18|      28|     491|     508|       3
---------------------------------------------------------------------------
  491-  508 (32.95/26.20)	DTDITMPTVTPMADVDHD
  522-  539 (32.01/25.18)	DSNLLGDTEDIMNDMGGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.77|      32|     857|      78|     131|       4
---------------------------------------------------------------------------
  100-  131 (55.12/58.24)	EPAALQKNRIPSNTTQNAPTNASATTSPAEPH
  954-  985 (58.65/23.31)	QPNRLQPRPIPGRDTNVEQLRANNLYQIPVPH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.58|      13|     226|     558|     573|       7
---------------------------------------------------------------------------
  543-  555 (23.83/12.58)	DHDVTEDDFNFFD
  561-  573 (22.75/ 7.02)	DMDLDMSDLQPIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.71|      21|     242|     137|     161|      13
---------------------------------------------------------------------------
  137-  157 (37.73/25.04)	ISPTQTA..GTQAEGGVQLPAQP
 1376- 1398 (31.97/11.64)	VSPEQTTtpATPMRETSTLAATP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.72|      16|     242|     737|     755|      15
---------------------------------------------------------------------------
  722-  737 (26.88/19.65)	GELKRDTEGLSRDEYL
  741-  756 (26.84/10.62)	GKLKPDSKTLPGVSLI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05023 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EPAALQKNRIPSNTTQNAPTNASATTSPAEPHQRNPLISPTQTAGTQAEGGVQLPAQPVD
2) GAFDFSKDQGSGELKRDTEGLSRDEYLERQGKLKP
3) GDARGWFAGTSEREERVSKRKAERAHAAPKEVNGANLQAQSLNGQSPLSVRRPSTAAAGVMYPTPPDAIQQHLGVTPSIDGATSSPNNAPPTLAVVDTDITMPTVTPMADVDHDGWEGGHEQKRERSDSNLLGDTEDIMNDMGGDVFGDHDVTEDDFNFFDGPDSNDMDLDMSDLQPISHPPPPQAILPQTIPPQAMPPPMITQPQPQKIIEPPPEIKPKPKTHEPVFAKPELKHARSSLNDELNHKVKTERSNSNKRGSSPFDPDTVFKRV
4) SKTLPGVSLIRTLTGADGSANHTNAQKSNGNASFSEDSDVDSEADDLSSLSGGPVSPIKSSVKRTVVDDDALSQATTSREAELMDDATEEQLAIELPKLSK
5) TPQANIVSPEQTTTPATPMRETSTLAATPGAE
100
711
395
747
1370
159
745
666
847
1401










Molecular Recognition Features






MoRF SequenceStartStop




1) VFKRVK
662
667