<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05019

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSDPAGEIVHITQGYIPLSKVLTRLAQSTHNALQDQIAALAKMPLPAAAVNGNSTIPNSDVEDASSENIAKKTSILNFAMREHRKWVKALVITEWSRKADMVSQLIDLRFHLQGQEVLFTGALDVMGHVKRDLTFARMPSPDLKTALQVLSTGEAAWMPDLSYIEPPPLTREEEIQWMSDVNTQLSLRLNLEDFDKIPHPFRNYEIDSGRVTFKVSGEFEVDLTIADEDFEKQFWFIDFRFAFKPATSWIPEGLKNYLESHVNDILSKDGLHGCYQFLHELVLTHKLNELKRQANQMSRGSWTGTLKVEPLNRALAIQYWTSRTQPGSPKSWVLVAVASGKKANGQPDSKLSSHLTAKWYRDNKEVKDENITFDTDNLSAEALMKTVIGRHIDFLLGSVHSRLLSFPRFQNRQAAMVLRSSRDDPAISSLIMQVGYKDSATLLIEPTTGVFAVKPHSKFTWSPENQLNNGKNPAEDGAACLENVRCAVMEDELSRRGSTTGWSIKRSPLNKDELRSLTNTREWTKTIWLHRAGWEANWFVMVLLSPSGDVWWLVDVNRNASGQAPRLASRLPLNKGYPRLDDEFWNNLTLFASGMIAQAVDQRELHKQNIKFKPHGANNWSLPQQVRLPTLEIALSGIFPFMVFDSAEKDNPKTAGNTESGKSGSVARSASRSSISTKQPWANDIVSVRFKGVQPAEAESTGPESVKLGDGKPEVPFTCVSDATIKVRRPAKFAMLKSHMVGRDVSWNARTGEFCLRMRSSMGQSMLESLKARVKAVDRFVSFFESMDRAKESIVAESVSLKEVTFSYGPLASEATNKDQPSRLWRITLNLSQNDIDLAMEETNPHLPVTNLMQKLVNGANGIGALMNWLPESLPALEAVKKIRETWRDVEARHQGRFRFMMDSVDEMSIQYSLVETGPGNQPVHRDITFLAHIKHRRVEPWWHIMRKPLNGPAPNDEFSKALKPVWEATGEKWTGLVTGAAGRPHDGIASLLLAIDEAVRPLAGSSFQNNSEVVVLE
Length1018
PositionTail
OrganismFusarium langsethiae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium.
Aromaticity0.08
Grand average of hydropathy-0.387
Instability index39.24
Isoelectric point7.73
Molecular weight114161.58
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05019
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.90|      33|      49|     647|     680|       1
---------------------------------------------------------------------------
  647-  680 (48.59/35.72)	AEKDNPKTAgNTESGKSGSVARSASRSSISTKQP
  698-  730 (56.31/36.58)	AESTGPESV.KLGDGKPEVPFTCVSDATIKVRRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.92|      20|      49|     447|     472|       2
---------------------------------------------------------------------------
  241-  263 (34.63/14.04)	FAFKPAT..SWIPEglkNYLESHVN
  451-  472 (35.28/20.80)	FAVKPHSkfTWSPE...NQLNNGKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.45|      27|     432|     502|     536|       4
---------------------------------------------------------------------------
  502-  536 (40.86/36.40)	WSIKRSPLNKDelrslTNTREWTKTIwlhRAGWEA
  943-  969 (53.59/27.29)	WHIMRKPLNGP.....APNDEFSKAL...KPVWEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.43|      33|     596|     269|     329|       5
---------------------------------------------------------------------------
  142-  179 (46.40/12.51)	DLKTALQVLSTGeaAWMPDLSyIEppPLTREEEIQ.WMS
  289-  322 (55.02/77.85)	ELKRQANQMSRG..SWTGTLK.VE..PLNRALAIQyWTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.15|      30|     596|     389|     418|       9
---------------------------------------------------------------------------
  389-  418 (54.77/41.27)	GR.H..IDFLLGSVHS..RLLSFPRFQNRQAAMVL
  983- 1017 (37.39/25.57)	GRpHdgIASLLLAIDEavRPLAGSSFQNNSEVVVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.63|      39|     142|     743|     784|      11
---------------------------------------------------------------------------
  743-  784 (60.49/65.96)	RDVswNAR.TGEFCLRMRS....SMGQSMLESLKARvKAVDRFVSFF
  888-  931 (62.14/51.73)	RDV..EARhQGRFRFMMDSvdemSIQYSLVETGPGN.QPVHRDITFL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05019 with Med14 domain of Kingdom Fungi
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