<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05006

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSSENQITLIVNDILKIEAVEEAFSCVLVHHPINESEKIAKWQAELSSALSNLNKEQQENAIKQFLFLAAAMTNHKRLQLLLSLLEYLVTSNILPARLVCECILNSDRLQYQSEDFWVECFVLIRHIIGGVDYKGVREIMKGCKEKAQTIPSRLDASVQSQLKALENVIEYIFDRNACLLPGYFIVTEIQKAYPDGKHWPHWKLAKLLSNFVESFRNTAQMVSIVGHSKMLPVVEHTGYADLINPWVLDTTTLKFSLKGNLPYDEDLLKPQTELLRYVLEQPYSRDMVCSMLGLQKQQKQRCIALEEQLVELVILAMERAENETLPAEGTDGTVANHYVWLHLSSQLIYFVLFSYACFPSIVMAIHDKLAGRDLRKGRDHLMWVLLQFISGSIQRNPLSNFLPVLKLYDLLYPEKEPLPVPDYTQALCTHQMAITCIWIHLLKKAQSEHSNIHRPIPHTLKLHHEFLQHLVMPNTSLCMGSDYRIALLCNAYSTNQEYFGRPMAALVDTILGTQKGQQQQPMQTLQNNAALASGPTTPLSMSILDSLTVHSKMSLIHSIVSHVIKSAQSKSNMALAPALVETYSRLLVYTEIESLGIKGFISQLLPTVFKSHAWGTLYTLLEMFSYRMHHIQPHYRVQLLSHLHSLAAVPQTNQTQLHLCVESTALRLITGLGSAEVQPQLSRFLSEPKTLVSAESEELNRALVLTLARSMHVTGTGSDSHSGTWCKELLNTIMQNTPHSWANHTLQCFPPVLSEFFQQNSVPKENKQQIKKAVEEEYRNWASMSNENDIIAHFSVPGTSPLFLCLLWKIIFETDRISPIAYKILERIGARALSAHLRKFCDYLVFEFANSVGGQHVNKCVDTVNDMMWKYNIVTIDRLILCLVLRTHEGSDAQVCFFIIQLLLLKAIEFRNRAQEFVKENSPEHWKQSNWHEKHLAFHRKFPEKFAPEGIMEQTSGGPSQYQSLPVYFGNVCLRFLPVFDIVVHRYLEIPAVSKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYERKLRDRPPLKRRLVSAVLGSLREIRAPGWALSEAYQMYMTRSSDDVVTWMPELDYYIRLVRRIVETMSGTAHFPATDWRFNEFPNPAAHALYVTCVELMAVPVAPNIVANSLLDVVAKGYTVIPSDEIHLWINCVGLLLAALPECYWSALHDRLVETINSPGLANWQYSNLTPFQIFNFNNTHNSLLENKFSYMLALAHSVWHHAGVGQITTMPQFIKEKLQPVVNSEEQLIYACHLIGPTLARFNAERPNCVVELTVRLYEMLEQVDRLQTHLKYMDPVCDLLYHIKYMFVGDMMKNEVECIIRRLRPALQMRLRFIAHINIDEIQSS
Length1355
PositionTail
OrganismMelipona quadrifasciata
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Apoidea> Apidae> Melipona.
Aromaticity0.09
Grand average of hydropathy-0.058
Instability index49.17
Isoelectric point6.72
Molecular weight155170.99
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05006
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     637.52|     201|     259|     808|    1026|       1
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  808- 1026 (314.42/238.26)	WkiIFETDRISPIAYKILERIGAralSAHLrKFCDYLVFEFANSVGGQHVNKCVDTVNdMMWKYNIVTIDRLILCLVLRTHEGSDaQVCFFIIQL.LLLKAI......EFRNRAQEFVkeNSPehwKQSNWHEKHLAFHRKFPEKFAPEGIME.QTSGGPSQYQSLPVYFGNVCLRFLPVFdivVHRYLEiPAVSkSLETLLE..HL.G.CLYKFH.DRPVTYLYNTLHYYE
 1075- 1288 (323.10/193.72)	W..MPELDYYIRLVRRIVETMSG...TAHF.PATDWRFNEFPNPAAHALYVTCVELMA.VPVAPNIVANSLLDVVAKGYTVIPSD.EIHLWINCVgLLLAALpecywsALHDRLVETI..NSP...GLANWQYSNLTPFQIFNFNNTHNSLLEnKFSYMLALAHSVWHHAGVGQITTMPQF...IKEKLQ.PVVN.SEEQLIYacHLiGpTLARFNaERPNCVVELTVRLYE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.89|      48|     388|     304|     361|       2
---------------------------------------------------------------------------
  304-  361 (72.68/47.60)	ALEEQLVELVILAMERAENETlpaeGT.....DGTvanhyvWL.HLSSQLIYFVLFSYA.....CFPSI
  694-  752 (73.21/32.01)	AESEELNRALVLTLARSMHVT....GTgsdshSGT......WCkELLNTIMQNTPHSWAnhtlqCFPPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     207.55|      61|     297|     146|     207|       4
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  146-  207 (102.23/74.55)	KAQTIPSRLDASVQSQLKALENVIEYIFDRNA..CLLPGYFIVTeIQKAYPDGKHWPHWKLAKL
  444-  506 (105.32/72.32)	KAQSEHSNIHRPIPHTLKLHHEFLQHLVMPNTslCMGSDYRIAL.LCNAYSTNQEYFGRPMAAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.43|      11|     301|    1027|    1039|       6
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 1027- 1039 (16.40/16.24)	RKLrdRPPLKRRL
 1331- 1341 (21.03/12.34)	RRL..RPALQMRL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.99|      23|     110|     640|     662|       9
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  640-  662 (40.25/32.49)	LSHLHSLAAVPQTNQTQLHLCVE
  753-  775 (38.74/30.93)	LSEFFQQNSVPKENKQQIKKAVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     172.38|      58|     530|      28|      87|      13
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   28-   87 (91.37/66.27)	LVHHPINESEkiAKWQAELSSALSN......LNKEQQENAIKQFL..FLAAAMTNHKRLQL..LLSLLEY
  559-  626 (81.01/52.60)	IVSHVIKSAQ..SKSNMALAPALVEtysrllVYTEIESLGIKGFIsqLLPTVFKSHAWGTLytLLEMFSY
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05006 with Med23 domain of Kingdom Metazoa
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