<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05001

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHPSHQTNGASLEDCHTNFFALTDLCGIKWKKLVWGEVAGDFGGTPLEDPVLSSFSRCLAGDILCVWRRVAATPATSGPATASATGAGIFDLGIAPSPAPPPLSLTAAKELWIFWYGEEPDLSGLVSPELIACESEQGSWESGLSYECRSLLFKALHNLIERCLLSRDFVRLGKWFVQPYDGFEKHRCSSSHLSFSFAFFVHGESTVCASVDVRQHPAVRHLTRTCLQRTQTTQSVILAPYGLAGTLTGPVGRTDSQLLEEWKHFYPINGSNVEAGLPSLVEVLVGGVRMRYPSCYVLVTDMDDTPSDTPLSPPNSPASYEHPLLSQQELRSATELPERVWAECTLNSPISASKTESSTESGTWTFIDPTQKSSCTCSKYATPGGWKSLASSQVQRERVDKGGRRVVPFHRRSTTQWDACPSVPANAPRSVLNRTEAPSTPPGGPPSYSRGPPTGGDCLPVPSVGSPGSPAPSPLPTPHSEPASVPPAEPTMPTLSPQPPPNHTNTAPPLTPSQGPKSTSSACNNQVHSPAPGPTLKRPVLAPRECEDIYLENEQSLHWLYDYSTQEAWLNHPVKRFKESNTSPVNVRSNTLYPPMNSQVPQSQTPKLEIKQEPNVNVGDCIGRRTDPYEFDATGEENGTNVDGLRRQRDDPTKPGSLFTSEGLQASYKDLDQIFDNSDPDTSSDETNLNQLQVQTPPESNRSGGLHEETRVDANNRHNNRGVGVLRPEELSKMFPTPPSLEHNPVASPCQLNDPLMDQTELSVPQRPLRHLPDIYPNMGSPQEESIDDWSYVFKPTPISPLGAPYRSATISGRPPPPPYDQPSPATSTTSSYLNKNLNSIEADTPGPTRAPESNSLIVNILLGDTVLNIFRDHNFDSCSLCVCNAGPKVVGNIKGADAGVYLTHSWSGGALFQDDDQIRCSCGFSAVVNRRLAHQAGLFYEDEMEITGIAEDPAEKKKTSLIAVACGGSKPLEGLDVIPPNVLELLREQCLIIQSSASSLYRASRIYSTMKSYPMLTPTVNMLEFNDGNEVSLAALDQGKINGTHNERTNRVIGVHRWVFLRAKGPQCSGDIVRMMRALQPLLQDAVQKKCTTRMWEAPYTVAGPLTWRQFHRLAGRGTDDRCEPQPIPALVVGYDRDWLSLSPYALSYWEKLLLEPYAGPRDVAYVVVAPDSDCVINKVKSFFRELSTTYEICRLGRHTPISKALRDGILRVGKASIQKQAKQPIDEWFKLLGENQLGELLRLYAQVCNHRLAPYLTQVIQDRSLLDPGDSQSINKQQQQQQQTTIPVTDTMPATPDVMTNKPESVEGENPRSETPSSNTATNNNSNTGNTTPTSQTATIHTNTTSGPDEEEVEPPAIVVYLVEPFSLGGPEDPDRRRLAILALLRAYSTAVNSMPENIRSNINVQIISLESIMELGRARERRKIQDEMRALALNVFLQGRRLLNHNSTVKSLTGFGTAAAADIFLKSKDSYSNTLATIHQERNRTPYRLYSPAYVLAPLRAKSEAPESFGIAGPEECAVLYLSYCLSEDQSWLLAVATDDRGEIFETATINIDIPNRKRRKRASARRIGLQKLMDFILGVMSQGVQPWRLVVGRVGRIGHGELKGWSWLLSRKALLKASKHLKEICGQCSLLYPSAAPCVLSACLVSLEPDSTLRLMADQFTPDERFSQASVNCQLSTPQDVTCTHILVFPTSATTQSSQTAFQEQHINGPELGDDELFSALNDDMPEGMEGMGDFNDIFNVWPEAGAGGGQSPNGSPHRPEGSPLGGDGGGSGLGNHDGPGSPFPCSNTPRVAVAEQAEEVGTLLQQPLALGYLVSTAPTGRMPPWFWSACPHLEGVCPVFLKNALHLHSPAIQQNSDDLLQQQSALTAHPLDSQYTTDVLRYVLEGYNALSWLAVDANTKDRLSCLPVHVQALMQLYHAAAALV
Length1930
PositionMiddle
OrganismMelipona quadrifasciata
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Apoidea> Apidae> Melipona.
Aromaticity0.07
Grand average of hydropathy-0.414
Instability index56.30
Isoelectric point5.58
Molecular weight211056.99
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05001
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     797.10|     194|     203|     201|     402|       1
---------------------------------------------------------------------------
   92-  191 (86.67/28.27)	......................................................................................................................DLG........IAPSP.A..P........PPLS...............................................lTAAKELWIFWYGEEPDLSGLvsPELIACESEQGSWESGLS.YEcrS....LLFKALHNLI.E................RCLLSRdFVRLGKWFVQPYDGFEKHRCSS
  201-  402 (320.29/145.78)	FvHGEST....VCASVdVRQHPAVRHLTRTCLQRTQTTQSvilAPYGLAGTLTGPvgRTDSQLLeEWKHFYPI.....NGSNVEAGL......PSLVEVLVG..GVRMRYPSCYVLVTDMD........DTPSD.T..PL......SPPNS................................................PASYEHPLLSQQELRSATEL..PERVWAECTLNSPISASK.TE..S....STESGTWTFI.DPTQ...........KSSCTCSK.YATPGGWKSLASSQVQRERVDK
  410-  608 (265.20/106.33)	F.HRRSTtqwdACPSV.....PA..NAPRSVLNRTEAPST...PPGGPPSYSRGP..PTGGDCL.......PVpsvgsPGSPAPSPL......PT.PHSEPA..SVPPAEPTMPTLSPQPP........PNHTN.TapPL......TPSQG................................................PKSTSSACNNQ..VHSPAPG..P.......TLKRPVLAPReCE..DiyleNEQSLHWLYD.YSTQeawlnhpvkrfKESNTSPV.NVRSNTLYPPMNSQVPQSQTPK
  611-  801 (124.94/45.74)	.................IKQEPNVN.......................VGDCIGR..RTDPY...EFDATGEE.....NGTNVD.GLrrqrddPTKPGSLFTseGLQASYK.......DLDqifdnsdpDTSSDeT..NLnqlqvqTPPESnrsgglheetrvdannrhnnrgvgvlrpeelskmfptppslehnpvasPCQLNDPLMDQTEL....SV..PQRPLRHLPDIYPNMGSP.QE..E....SIDD..WSYVfKPTP...........IS.............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     452.73|     150|     202|    1146|    1316|       2
---------------------------------------------------------------------------
 1146- 1316 (216.63/214.26)	PYALSYWeklLLEPYA..GPRDvayvvvaPDSD..CVINKVKSFFRELSTTYEICRLGRHTPIsKALrDGILRVGKAsiqKQAKQPIDEwFKLLGENQLGELLRLYAQVCN.HRLAPYLTQVIQDrSLLDPGDSQSINKQQQQQQQTTIPVTDTMPATpdVMTnkPESVEGENPRS
 1358- 1512 (236.10/166.71)	PPAIVVY...LVEPFSlgGPED.......PDRRrlAILALLRAYSTAVNSMPENIRSNINVQI.ISL.ESIMELGRA...RERRKIQDE.MRALALNVFLQGRRLLNHNSTvKSLTGFGTAAAAD.IFLKSKDSYSNTLATIHQERNRTPYRLYSPAY..VLA..PLRAKSEAPES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     394.78|     126|     703|     842|     985|       6
---------------------------------------------------------------------------
  842-  985 (197.08/127.26)	IEADTPGPTRAPESNSLIVNIL.LGDTVLNIFrDHNFDSCSLCVCNAGPKVVGNIKGadagvyltHSW..SGGALFQDddqircSCGFSAVVNRRLAH...QAGLF.YEDEMEITGIAEDPAEKKKTSLIAVACGGSKPlegLDVIPPNVL
 1554- 1692 (197.69/105.56)	INIDIPNRKRRKRASARRIGLQkLMDFILGVM.SQGVQPWRLVVGRVGRIGHGELKG........WSWllSRKALLKAskhlkeICGQCSLLYPSAAPcvlSACLVsLEPDSTLRLMADQFTPDERFSQASVNCQLSTP...QDVTCTHIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.10|      18|    1730|      41|      59|       7
---------------------------------------------------------------------------
   41-   59 (32.24/22.38)	GDFGGTPL..EDPVLSSFSrC
 1772- 1791 (34.86/19.39)	GDGGGSGLgnHDGPGSPFP.C
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05001 with Med13 domain of Kingdom Metazoa
Unable to open file!