<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP05000

Description Mediator of RNA polymerase II transcription subunit 25 (Fragment)
SequenceADVVFVIEGTAVNGAYLNDLKTNYLTPTLEYFSQGGIEDREYVSEQNSTTLYGIVVYHAADCLPAPCTETFGPYANPHKLLLVLEKLEMVGGKGECYANIGEGLATGLQCFEDLQLRREPNTASQKHCILICNSPPYQTVIQESYKFAGHTIEQLASLYQERNINLSILSPRKIPALFKLFEKAGGDLQSSQTKNYAKDPRHLVLLRNYNLKERPVSPTIGGAVHTTPGTTAQIPLSPLQSNDSPTTNQVQQNIAQPTQPQGPPFRSQTPQNITSVHQTVVPMTATMNAGRPPYNPQISAPPTYHPPRAGQPRWRNLPPFVPTGPTNTQSSALIAQLNQPPPSMGLNVPPFGQRMDVTNTNVMAASVQQQQQQQQQQQQQQLSQQQQLRITMQLQQQQQQQQQQQNVQQPSSMPITAQPTHGQAGPQLTVSCVSQSVPTQVPQTVTASQTQASVSSVTQQQQITHPQTQGNVTVGTVGPGPQISTPRERQTIWHGIIEWVEKAKTTPDAPKQTRHLPCQVSANSKDGDPELKADTWPQKLIMQLMPKQLIGNIGGSYLKNSKSVLFHPTPCEALESLTKVMNSGFAGCVHFTFLQAACDIKILILLYTAERRTYLGFIPNDQTGFVDRLRKVIQQQKTSHASMRQGQAGTAQGNAIAGAMPTTGTSQGGILMSQTNPIAMGGGQITQNVVSTNAPQQTLTSSAGPQNQIDMQSGGITGPQVAPASGTMIGQQRPIDNIEIARQQNLIKIHQLRQTLEAAQQQEAQYKSQLEVNIQQNLEVAQQQEMQYKQQLEAQQAQRALNPAGMTNQQANAPRPLMRPVPNIGLRHLLQQPQPQYRQVIGLQQQMVPRGQMTTRPMAPGNPQNQQFEDVSNYDFLG
Length878
PositionUnknown
OrganismMelipona quadrifasciata
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Apoidea> Apidae> Melipona.
Aromaticity0.05
Grand average of hydropathy-0.571
Instability index58.68
Isoelectric point8.86
Molecular weight96379.70
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP05000
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     128.75|      24|      24|     370|     393|       1
---------------------------------------------------------------------------
  377-  401 (39.17/12.84)	QQQQQLSQQQQLRIT......MQ....................lQQQQQQQ
  402-  446 (26.91/ 6.32)	QQQQNVQQPSSMPIT......AQpthgqagpqltvscvsqsvptQVPQTVT
  759-  788 (29.91/ 7.92)	AQQQEAQYKSQLEVN......IQ...............qnlevaQQQEMQY
  808-  837 (32.76/ 9.43)	NQQANAPRPLMRPVPniglrhLL.....................QQPQPQY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     155.64|      27|      27|     238|     264|       2
---------------------------------------------------------------------------
  249-  267 (30.51/ 9.74)	QVQQNIAQPTQ...P.......QGPP............................fRS
  268-  305 (33.38/11.51)	QTPQNITSVHQtvvPmtatmnaGRPPynP.Q......ISAPP...........T.YH
  467-  489 (31.51/10.35)	QTQGNVTVGTV............GPG..P.Q......ISTPR...........E.R.
  645-  677 (32.29/10.84)	QGQAGTAQGNA...I.......AGAM..PTTgtsqggILMSQ...........T.NP
  684-  719 (27.95/ 8.15)	QITQNVVSTNA...P.......Q..Q..TLT......SSAGPqnqidmqsggiT.GP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.06|      13|      19|     215|     227|       4
---------------------------------------------------------------------------
  215-  227 (23.99/11.70)	PVSPTIGGAVHTT
  235-  247 (24.08/11.78)	PLSPLQSNDSPTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.94|      14|      31|     326|     339|       6
---------------------------------------------------------------------------
  326-  339 (22.94/14.08)	TNTQSSALIAQLNQ
  358-  371 (24.00/15.12)	TNTNVMAASVQQQQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP05000 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HGIIEWVEKAKTTPDAPKQTRHLPCQVSANSKDGDPELKA
2) PVSPTIGGAVHTTPGTTAQIPLSPLQSNDSPTTNQVQQNIAQPTQPQGPPFRSQTPQNITSVHQTVVPMTATMNAGRPPYNPQISAPPTYHPPRAGQPRWRNLPPFVPTGPTNTQSSALIAQLNQPPPSMGLNVPPFGQRMDVTNTNVMAASVQQQQQQQQQQQQQQLSQQQQLRITMQLQQQQQQQQQQQNVQQPSSMPITAQPTHGQAGPQLTVSCVSQS
3) QQEMQYKQQLEAQQAQRALNPAGMTNQQANAPRPLMRPVPNIGLRHL
4) TQVPQTVTASQTQASVSSVTQQQQITHPQTQGNVTVGTVGPGPQISTPRERQT
5) VIGLQQQMVPRGQMTTRPMAPGNPQNQQFEDVSNY
6) VVSTNAPQQTLTSSAGPQNQIDMQSGGITGPQVAPASGTMIGQQRPIDN
494
215
783
439
840
689
533
436
829
491
874
737










Molecular Recognition Features






MoRF SequenceStartStop




NANANA