<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04999

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMSGMPTAKNSIEMENHVFQKAKTKEEYLGFVARLILHVRELNSKKGTGGNAPGTAGAGNQGMPDPIGALQTLARQGTGNNQMMNINGPGSNPQGIIPQPPTNTATNLLQSLNQRPGQAMTMQSMQSKISGMGMMSAQTSGPMNHMGPIQTMQTNSMLTQMNSMGQGNIPQQMNQMVPNQMAQITTGQMQQNMQTQMQNQLSNQIGNQISGSISGIQTNMPQQMNQIAPGQLGPGQMQQQLSHIQRKQGEIINAGFPGPRNVTPNQFLGQSPSPSAPSPAGLGAPSSNQMVASPALVPSPSSQHMMAGPQRSVGMAPSPSSSLNTPGGVGATPSPQQEDQAYRDKVRQLSKYVEPLRRMIAKMGNEGNVDKLSKMKKLLEILSNPSKRMPLDTLLKCEVVLEKLDFKRSDASVGPPITTLKEHHFFSPLLEAVSTHLQSPVVNHTLQRTFGPCLEALFGPEIKNLPPPLKKQKIEESPSEIPDVLQGEIARLDQRFKVSLDPAQQTGSKCIQLICWLDDRHLPCVPPVSVTVPADYPLTPPRCVMAPHEYATTFLCAVQRALNARITKLPRRFSVSQLLDTWEMSVRQASAPSQIPVNTSTILMGL
Length605
PositionTail
OrganismMelipona quadrifasciata
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Apoidea> Apidae> Melipona.
Aromaticity0.03
Grand average of hydropathy-0.447
Instability index54.30
Isoelectric point9.50
Molecular weight65477.62
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04999
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     179.66|      29|      29|     117|     145|       1
---------------------------------------------------------------------------
   60-   82 (28.05/ 9.26)	...........QGMPDP............IGAL.....QTLARQGTGN...NQM
  117-  145 (55.23/25.79)	QAMTM......QSMQSK............ISGM.....GMMSAQTSGP..MNHM
  149-  175 (39.97/16.51)	QTMQT......NSMLTQ............MNSM.....G....QGNIPqqMNQM
  179-  226 (26.75/ 8.47)	QMAQIttgqmqQNMQTQmqnqlsnqignqISG......SISGIQTNMPqqMNQI
  230-  260 (29.66/10.24)	QLGPG......Q.MQQQ............LSHIqrkqgEIINAGFPGP..RN..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      55.06|      17|      23|     415|     431|       2
---------------------------------------------------------------------------
  415-  427 (18.41/10.09)	...............PITTLKEHHFFSP
  428-  451 (21.08/12.65)	LLEA....vsthlqsPVVNHTLQRTFGP
  452-  477 (15.58/ 7.38)	CLEAlfgpeiknlppPLKKQKIEE..SP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.73|      20|      24|     350|     373|       3
---------------------------------------------------------------------------
  350-  373 (28.37/27.38)	KYVEPLRRMIAKMGnegnVDKLSK
  376-  395 (32.36/19.55)	KLLEILSNPSKRMP....LDTLLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.51|      14|      18|     297|     313|       4
---------------------------------------------------------------------------
  303-  321 (16.83/10.60)	HMMAGpqrSVGmaPSPSSS
  322-  335 (25.68/ 9.01)	LNTPG...GVG..ATPSPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.31|      11|      25|     264|     274|       5
---------------------------------------------------------------------------
  264-  274 (22.18/10.67)	NQFLGQS...PSPS
  287-  300 (17.13/ 6.45)	NQMVASPalvPSPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.02|      18|      24|     488|     505|       7
---------------------------------------------------------------------------
  483-  500 (29.18/18.59)	VLQGE.......IARLDQRFKVSLD
  501-  525 (27.84/17.42)	PAQQTgskciqlICWLDDRHLPCVP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04999 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LNSKKGTGGNAPGTAGAGNQGMPDPIGALQTLARQGTGNNQMMNINGPGSNPQGIIPQPPTNTATNLLQSLNQRPGQAMTMQSMQSKISGMGMMSAQTSGPMNHMGPIQTMQTNSMLTQMNSMGQGNIPQQMNQMVPNQMAQITTGQMQQNMQTQMQNQLSNQIGNQISGSISGIQTNMPQQMNQIAPGQLGPGQMQQQLSHIQRKQGEIINAGFPGPRNVTPNQFLGQSPSPSAPSPAGLGAPSSNQMVASPALVPSPSSQHMMAGPQRSVGMAPSPSSSLNTPGGVGATPSPQQEDQAYRDKVRQ
41
347










Molecular Recognition Features






MoRF SequenceStartStop




NANANA