<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04997

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMAMLDKRFAIDSAEKSQLQKCLDTLQHSIKVTSLQSMVERLESLTRQLGLKFMMSGPLATELFISSDMFFLEVLLEPTGVVKDVKIHHEGKNEQQSCDVLVSCLSRGDFLDFTVQLEGLASIYQLNADKKIKCKAFSALQSLEADLGILAQLQTFIKEPFNLVHKSPVGILERRRGGHAMKLTYFVSPYDLIDQENRTCDALNSEIVIKRKIGHSVTVCMEGSTAHKLPTSSIITVNRSPTGKSTPSYAPLTGTNSSVLPACFVLKLAKKMPMCMELVRRIQKVTELECGDISAPHPLLSLIIQYASEGQLDCRNNRGLYATLPDQQHCYFMTENKNMEGVLVCSIPFTHPAHVPQILVYLRQQALFNTLIASCVRPMARQDPEHATIFEVSALSWQHISVSLEHPFEETMATAELDLTDISALKCKLYGISITNTEQTSDLTGKVLQKCLSIPLTMRILMKSWESRDSLSTMNNLNSGNGNYNVNHGSGKDPSSQNDAGTENSIGFPSYSGQSDTATTAMLNPLQLGALLGQAKNSMTNPMNERTKKTRKRKAADENKSLVPPSVSITPISSSSLGQTTNYNSVLTGMGLERRPGIEIIPIASSPQTTLPSSITITPIAGPTQSKNLTDERRERKSSKGKSTEDKGKLEKRRKRKREDSPMGPPPDKISKQDPLSKPVSVSIKPTESPPNLSSRPSSPATTLRKFSPSPTHTSPLALVGKSSPTLKQSANKPVQSPKHSPVYSSSPKHTPVPASVSPKHGTSSPKHGSSASTGKPSMSALKSAANSPSSKTTDSGQSKIKSSSSSSSKDSAREKERKTSSLAFGGSSGHQSPKTKSSSGKLKQLELIPSGEAQTTLPGSGGNTPPSGNSELGKSAIAQQQARNRKGSLSAVIDKLKNAQHCTDDGGNGGTKSTAAGSGNSGSQKERSLGGSSNKATEGKCISKNSSMDTKNPAEYMVKHSSDGMKITINKTRTKDSKSGANLKLSSSSTNVATGTSLSSSASSTTISGNGSPKTHTGLKPGVSSGPASKKPPSQTSPKLSGSSSGGTSGNKTTLLGQKMLTALKSISGSNPGSGNGAGGISVGSSSTSALLSKNVMSSKSSSSSPKTASSGVTDLSRNRDKSRLSKSGDKSIFPSKGIGDTRKSSPSGLREESESERAFKLLAAHASMSNLSNLPNLPPQLVVEGLMKQLDTKFQIPKLSARANADSSDKKSEKLSMLPDSGKTLDNLAAKQTTEQGKLQTLSNTSSTVSKTSSEDQSSQSRRDHVQTKPDNLSMTSATSIINLGTDSASNLLLPALSSSSSHDLDIPTNLSMQSTENESRDKEPPMSRSNTQFLGSSLNSTAIGKDDNSGPVMAVLPKGSDSQPTSKSVYPTMMTTGTITSGNGGTVTTSSGNGTSESLNLSIKPVDATMTNTMKPPGTEIPTTTSQEAAEMLLDFSTPKDVAKSLNFTSIPERAMTQAASVRRNTPPPPPPAFPASPSVSVHIVKSPAPSPRVIPPSPHSASPCITDDELMDEALVGMGK
Length1523
PositionMiddle
OrganismMelipona quadrifasciata
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Apoidea> Apidae> Melipona.
Aromaticity0.03
Grand average of hydropathy-0.538
Instability index54.11
Isoelectric point9.50
Molecular weight161269.13
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04997
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.13|      22|      26|    1092|    1115|       1
---------------------------------------------------------------------------
  762-  784 (29.24/ 7.93)	TSSPKHGSSAST..GKPSMSAlKSA
 1103- 1126 (22.88/ 8.80)	SSSPKTASSGVTdlSRNRDKS.RLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     258.21|      44|      46|     618|     661|       2
---------------------------------------------------------------------------
  526-  579 (38.53/10.88)	QLGALLG...QAKNSMTNPM..NERTK..KT..............RKRKAADEN.kslvppsvsitPI..........................S.ssslGQT
  624-  679 (60.33/21.37)	QSKNLTDERRERKSSKGKST..EDKGKLEKR..............RKRKREDSPmgpppdkiskqdPL..........................S.....KPV
  680-  725 (41.52/12.32)	SVSIKPTESPPNLSSRPSSP..A..TTL...................RKFSPSP........thtsPL..........................AlvgksSPT
  728-  788 (36.38/ 9.84)	QSAN..KPVQSPKHSPVYSS..S.....PKH..............TPVPASVSP..............khgtsspkhgssastgkpsmsalksaA.....NSP
  789-  829 (36.04/ 9.68)	SSKTTDSGQSKIKSSSSSSS..KDSA...................REKERKTSS........lafgGS..........................S.....G..
  988- 1044 (45.40/14.19)	SSTNVATGTS..LSSSASSTtiSGNGS.PKThtglkpgvssgpasKKPPSQTSP............KL..........................S.....GSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.66|      23|      28|    1454|    1480|       3
---------------------------------------------------------------------------
 1412- 1427 (23.80/ 8.30)	....MT.......NTMKP...PGTEIPTTT
 1454- 1480 (41.43/30.40)	PERAMTqaasVRRNTPPP...PPPAFPASP
 1483- 1506 (33.43/15.47)	SVHI......VKSPAPSPrviPPSPHSASP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     178.34|      47|     427|     467|     518|       4
---------------------------------------------------------------------------
  467-  494 (38.37/13.01)	...................................R.....DSLS.TMNNL........NSGN.GNYN.VNHGSGKDPS
  851-  922 (44.00/26.71)	GEAQTTLPGSGGntppsGNSELGKsaiaqqqarnrK.....GSLSaVIDKLknaqhctdDGGN.GGTKsTAAGSG.NSG
  923-  967 (54.31/23.58)	SQK....ERSLG.....GSSNKAT.........egK......CIS.KNSSM........DTKNpAEYM.VKHSSDGMKI
 1049- 1085 (41.67/16.13)	SGNKTTL..............LGQ...........KmltalKSIS.G.SNP........GSGN.GAGG.ISVGS.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.56|      13|      28|    1237|    1249|       5
---------------------------------------------------------------------------
 1237- 1249 (21.96/ 9.36)	QGKLQTLSNTSST
 1268- 1280 (21.60/ 9.07)	QTKPDNLSMTSAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.62|      27|      28|     137|     163|       6
---------------------------------------------------------------------------
  137-  163 (43.67/29.48)	SALQSLEADLGILAQLQTFIKEPFNLV
  166-  192 (47.95/33.10)	SPVGILERRRGGHAMKLTYFVSPYDLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.15|      14|     339|      92|     105|       7
---------------------------------------------------------------------------
   92-  105 (26.92/18.09)	NEQQSCD....VLVSCLS
  435-  452 (20.23/11.72)	NTEQTSDltgkVLQKCLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.69|      27|      28|     202|     229|       9
---------------------------------------------------------------------------
  203-  229 (46.75/24.03)	NSEIVIKRK.IGHSVT..VCMEGSTAHKLP
  231-  260 (35.94/13.28)	SSIITVNRSpTGKSTPsyAPLTGTNSSVLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.25|      22|      29|    1284|    1311|      10
---------------------------------------------------------------------------
 1285- 1309 (30.88/18.80)	LGTDSASNLLLPALSSSSSHDldiP
 1345- 1366 (36.37/13.52)	IGKDDNSGPVMAVLPKGSDSQ...P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.58|      19|      41|    1172|    1190|      12
---------------------------------------------------------------------------
 1178- 1199 (26.60/13.44)	LPPQLVVEGLMKQ...LDtkfQIPK
 1200- 1221 (23.98/11.31)	LSARANADSSDKKsekLS...MLPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.58|      14|      28|     390|     403|      13
---------------------------------------------------------------------------
  390-  403 (23.83/16.61)	EVSALSWQHISVSL
  420-  433 (23.76/16.54)	DISALKCKLYGISI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.21|      14|      41|    1089|    1102|      14
---------------------------------------------------------------------------
 1089- 1102 (20.41/ 9.09)	SALLSKNVMSSKSS
 1147- 1160 (17.80/ 6.86)	PSGLREESESERAF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04997 with Med1 domain of Kingdom Metazoa
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