<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04990

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMLILGGQKSTASGILSQGRSRATYVTELIIHVPTGRPLVLLSSPTQAIGFANFRRGVTSRCIDAMADSFTLPLRPIPEKRDRPDTLPVEIAQINNQWGSFREVNEDVLRNKIVEEEEKDGLDEVDESDQDGSDLDSTERLEQLYKRRAEITQFAMQAHMETMFALDFVSLLLSKQAPRQAETSMSAFLKQVAPLGSLNAEVVNPPPKPESKTKDISAVSRGWRIQNFNAAANKLLQAASRLETEVASETRYWNEVLAVKDKGWKVSRLPSEKQSLGVQYGFLEATPVFRDRGLASLRRAEDGALLLDEGLIPSKARFVRVRVIQNGRLSGSSKPTRSTFNGNETIEDRILQARDTVYEEELFHELVREARAIASFGVTTRQNLIQIPASDDLEILLDLVDTDEDTPEPEHDISQQQTSLAEGLAHTIRILLAYAHRQNLRRRTLLPLPLTPKTRSVPENQLIRPALAYIQHMSHVRWLQSLLKDLFGVLQSAGLEPPAYTSRVFSTARRQTSPAPAVETLVGQFLTPLLSTFNGKISTPRGSFSIAIHTNLSLPPFGTSFDVSFIMPKYPDLESPGKLSHREEVEAAITHLLLLDVVSTVSSNGGLPQPESDKDETKGTWEAIYPQHGELLIPSKSEKRKKMKIALSRHELSLEIYTVRCIDGTGRGHWELPSYHSMPHTWKPSPTAGSPKQSSLMDCVLTEVSRS
Length706
PositionHead
OrganismPenicillium nordicum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.06
Grand average of hydropathy-0.384
Instability index53.34
Isoelectric point6.30
Molecular weight78666.36
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04990
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.21|      18|     192|     394|     411|       1
---------------------------------------------------------------------------
  394-  411 (33.66/16.83)	ILLDLVDT...DEDTPEPEHD
  592-  612 (27.55/12.67)	LLLDVVSTvssNGGLPQPESD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.38|      28|     164|      33|      97|       2
---------------------------------------------------------------------------
   58-   85 (51.73/78.07)	TSRCIDAMA.DSFTLP.LRPIPEKRDRPDT
  657-  686 (49.64/11.31)	TVRCIDGTGrGHWELPsYHSMPHTWKPSPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.23|      19|      38|     427|     445|       3
---------------------------------------------------------------------------
  427-  445 (33.16/20.35)	IRILLAY.AHRQNLRR.RTLL
  462-  482 (28.07/16.22)	IRPALAYiQHMSHVRWlQSLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.09|      35|      39|     515|     551|       4
---------------------------------------------------------------------------
  515-  551 (51.38/45.58)	PAVET.LVGQFLTPLLSTFN..GKIStPRGSFSIAIhTNL
  554-  591 (54.71/37.57)	PPFGTsFDVSFIMPKYPDLEspGKLS.HREEVEAAI.THL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.84|      32|      45|     246|     282|       7
---------------------------------------------------------------------------
  246-  282 (49.12/45.47)	ASETRYWNEVLAVkDKGWkvsrLPSEKQSLGV...QYGFL
  294-  328 (45.73/28.47)	ASLRRAEDGALLL.DEGL....IPSKARFVRVrviQNGRL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04990 with Med17 domain of Kingdom Fungi
Unable to open file!