<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04989

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLIMEEGINVDDLFGEPNSLELGLPAASPIKGLAQCLDEMRLLGCCQKIAWSRMGCIASISPDRLRVIVRHLQCRPSDGKWVLGEESSLAPVLEAHNGNQLAHLSWNETGSELAVVDCSGRISIYSISIALNSITGLRQASFDSGDDGNQVVGMMWLNSQRYVHAFHQAAKVNGRWAYSPFRRRPVGPFHPANKGALICVTRAGQIKLIYQNPDSKWAELPAELKNTGYSDRLLTHASMTATQAGILLSTYSACQKMCLYRVHISWNPSQWEPVQGKPPGQFPIPTFRLIHCKVDMPSNILNINRGPDHSDQSLPFLNSVYSLTRLEIMPGQFDSPAGSTASPWILAVLSKPLHAIHDYPDQQGPPSVIVRWHLESAPQILHPKFDEVTSKKSNVQAKPKMELRRLEDVYCDKYIVSVDLVEHGTVLAVTHDDSSITCYDTRTMTVLNGLDDSTTVTCLAQAGFQYPLETSGLHIAFSPNACVAVTLDIDGHMQLRVMEHSFGSTEGLHDENNFSAAIAALTLSFSRGCGVDFNTDDILVVALGQLSPEAQTTFISEVYRALPVNCNFTAEQDKLMSHPYIPRCLSLQAGLGFKGRLKRRNLSSAVPWASLQLRHASVLFAYFFQYNKGGQTESHDPDVLRMVLGNTKWALDFSHFLLSEIFDMADEFEDVYHDPEAFTHKLKNSSSLPLLILLSSMSRAFLRFICRGLRGVHAGFTSANPASLVGDSRIYYTEICQTLESSPVRIDVYEKFLAGVDSAVKHAYQGAGFGDAERPGPEKELLVNARIPPVLTTAVATLLRQTVPALKSEINRRAIYLGDYSWLGFGNDRRTALYRKQREVDILKKCPLRPPLPLGNDGRVALLKKRRCARCCEVSGDTNLPRSLLSFKMIAKLGLLRSCLCGGMWVLETDTGELGARTASANGSSNRVSQA
Length932
PositionTail
OrganismPenicillium nordicum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.08
Grand average of hydropathy-0.142
Instability index43.81
Isoelectric point7.32
Molecular weight102903.60
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04989
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.88|      16|      27|     824|     839|       1
---------------------------------------------------------------------------
  824-  839 (30.67/25.58)	LGFGNDRRTALYRKQR
  853-  868 (29.21/23.92)	LPLGNDGRVALLKKRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.52|      28|      31|     308|     337|       2
---------------------------------------------------------------------------
  280-  330 (38.20/22.72)	PGQFPIPtfrlihckvdmpsnilninrgP.....DHSDQSLPflNSVYSLTRLE....IM
  331-  382 (37.32/16.77)	PGQFDSP......agstaspwilavlskPlhaihDYPDQQGP..PSVIVRWHLEsapqIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.01|      17|      36|     471|     488|       3
---------------------------------------------------------------------------
  471-  488 (27.22/20.91)	TSGLH..IAFSpNACVAVTL
  506-  524 (25.78/14.06)	TEGLHdeNNFS.AAIAALTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.85|      28|      38|     609|     645|       4
---------------------------------------------------------------------------
  609-  639 (44.26/43.14)	WAsLQLRHasVLFAYFFQYNKGGQTESHDPD
  650-  677 (52.59/26.88)	WA.LDFSH..FLLSEIFDMADEFEDVYHDPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.19|      12|      31|     699|     710|       6
---------------------------------------------------------------------------
  699-  710 (22.44/13.56)	SRAFLRFICRGL
  729-  740 (22.75/13.84)	SRIYYTEICQTL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04989 with Med16 domain of Kingdom Fungi
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