<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04986

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDRTHLTSFQARPPSPSSPAGSLKENHRLPISSEHIPQTPTSPPLMSVNEQSHAANFTSSHTSPNQATVQPPNISSPPSSAPMSTQVSQQPTMSTTNSLPTPASSVSSHPANATSEDVDQGRKSFNMGIQDSAENSGAAPAQRQTQQQTQHRPTDHDRQSLQTESTNEFANGQGQHSTDPDAMDVDTEPTRRADTLSLDFDSLQKELTSAFHLCKSSPIVTGPDPSVDLVSLYGLGSIAHSVARMDPVTGEKINRLRKSYEGKLKGLGLAGRNKPHKQEIGAPGSLRYMTLWPEEEWQNQKVHGKAIKVSDMDSALQNLQSRAMQMEPGPIPNNDWWEDILGHEKQAKNPAPGETSKKAAPAPTAGRPSMQSYAASPRSQEAERPRPSRGRKRNYDDNSFAGYGEGFVDDDDDPGFYSNGEGSGKKKRKKVSTPMSERSASYGVGMFGIGAR
Length453
PositionHead
OrganismPenicillium nordicum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.05
Grand average of hydropathy-0.966
Instability index58.66
Isoelectric point6.55
Molecular weight49019.26
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04986
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.20|      21|      21|      60|      80|       1
---------------------------------------------------------------------------
    6-   22 (25.40/10.43)	..HLTSFQA..RPPSPS.SPAG
   34-   53 (30.71/14.30)	SEHI.P.QTPTSPPLMSvNEQS
   60-   80 (41.09/21.88)	SSHTSPNQATVQPPNIS.SPPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.73|      20|      21|     152|     172|       2
---------------------------------------------------------------------------
  152-  169 (28.40/18.10)	......HRPTDHDRQSLQTESTNE
  171-  193 (28.78/21.32)	ANgqgqH.STDPDAMDVDTEPTRR
  194-  211 (28.55/14.48)	AD....TLSLDFD..SLQKELTSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.78|      17|      21|     352|     368|       3
---------------------------------------------------------------------------
  352-  368 (29.32/11.53)	APGETSKKAAPAPTAGR
  376-  392 (30.45/12.21)	ASPRSQEAERPRPSRGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.40|      19|      21|      88|     106|       4
---------------------------------------------------------------------------
   93-  111 (31.66/15.87)	TMSTTNSLPTPASS..VSSHP
  112-  132 (21.74/ 8.72)	ANATSEDVDQGRKSfnMGIQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.20|      20|      20|     263|     282|       5
---------------------------------------------------------------------------
  263-  282 (34.32/19.72)	GKLKGLGLAGRNKPHKQEI.G
  285-  305 (33.88/19.38)	GSLRYMTLWPEEEWQNQKVhG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.83|      11|      14|     397|     407|       7
---------------------------------------------------------------------------
  397-  407 (22.39/13.84)	DDNSFAGYGEG
  413-  423 (23.44/14.81)	DDPGFYSNGEG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04986 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSDRTHLTSFQARPPSPSSPAGSLKENHRLPISSEHIPQTPTSPPLMSVNEQSHAANFTSSHTSPNQATVQPPNISSPPSSAPMSTQVSQQPTMSTTNSLPTPASSVSSHPANATSEDVDQGRKSFNMGIQDSAENSGAAPAQRQTQQQTQHRPTDHDRQSLQTESTNEFANGQGQHSTDPDAMDVDTEPTRRADTLSLD
2) NQKVHGKAIKVSDMDSALQNLQSRAMQMEPGPIPNNDWWEDILGHEKQAKNPAPGETSKKAAPAPTAGRPSMQSYAASPRSQEAERPRPSRGRKRNYDDNSFAGYGEGFVDDDDDPGFYSNGEGSGKKKRKKVSTPMSERSASYGVGMF
1
300
200
448










Molecular Recognition Features






MoRF SequenceStartStop




1) DWWEDILGHE
2) GYGEGFVDDDDDPGFYSNGEGSGKKKRKKVSTPMSERSASYGVGMFG
336
403
345
449