<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04976

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLILDNAVPVDLNDVDDLFGDAVGLSLQERSQSKLAVFDALGRVALVSFPISLNSPYLTRKWDADALDDVNAVAASYWLPLAHPNPQKPFVATYGPATRNGYQYHYEKSVVHAVAPSHPHLAKSALVCVTLNGSLKLFWSQNNNKLEETVIELESVLSADELVTHAAIGSDKKNLLVAVATSSRQLRLIKIEIEWAGPGSQTDKTSLPQNARLSPSLIETHLAATSWLQAVPGDAGNDASLAELSSLHLLPSVLESTGKSTAAPMIVTVRSRAHHAGSYQMAQTIIDRWEVLGEQQRNLHPAFEQLGSRRNDGPEEQGLYTRLRKLEPVILNRVVLLLQVTQHGRVLVLVMSDGTVEYRDRLSFEEIYQNEGTDRIMNLRQVGWAFSDEGLCQQVAFSPTQCSMIQLGEDGKFRWIKLHFPLGDIGNSHQDGFAQDWVNEIIRILKIQVDYSEELHHESLMRNTPLHSCLSIMNSLGFRGELQPRSFQGKLAMIEVNARNVVILITLASNTPSTGRENLSPLDDHGCGKWSVDLLSWLLDSLFGLMSDDEFTARLVSARFGEITPYLQEQNNVALHLLLSSCSRSFLLAMCRRISHLEALSTRAIEFYQRQSASGNQPRAPNSQLQQAYQRMQAITTSSPVKVHEFEKLLNALGSDIRATYSQCLPAMTKSGGNAPQGKQMDVVVKGRQIQYEMAMLNAASPPNFFLPVMKKLFGTYLPAFRNSVDPTSLFFADYEILGIQDDRTSLAAREAKGVYVDLFRRAVLKKGGQQQWRRCTRCASVMEDVSGTRPGFTFVLSQQRKCSCGGFWALLPKEKFVL
Length820
PositionTail
OrganismEscovopsis weberi
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Escovopsis.
Aromaticity0.08
Grand average of hydropathy-0.186
Instability index44.81
Isoelectric point6.61
Molecular weight91175.95
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04976
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.78|      43|     186|     188|     238|       1
---------------------------------------------------------------------------
  188-  238 (60.89/49.69)	RLIKI.EIEWAgpgsQTDKtSLPQNARLSP...SLIET.HLAATSWLQ..avpGDAGN
  376-  428 (60.89/30.73)	RIMNLrQVGWA....FSDE.GLCQQVAFSPtqcSMIQLgEDGKFRWIKlhfplGDIGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     240.06|      56|     121|     431|     486|       2
---------------------------------------------------------------------------
  431-  486 (96.96/76.16)	QDGFAQDWVN....EIIRILKIQVDYSEELHHE..SLMRNTPLHSC..LSIMNSLGFRG.ELQPR
  549-  611 (72.20/54.52)	DDEFTARLVSarfgEITPYLQEQNNVALHLLLS..SCSRSFLLAMCrrISHLEALSTRAiEFYQR
  625-  677 (70.90/53.38)	QLQQAYQRMQ....AITTSSPVKVHEFEKLLNAlgSDIRAT.YSQC..LPAMTKSG..G.N.AP.
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04976 with Med16 domain of Kingdom Fungi
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