<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04969

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMTSDAETLRISVERVQAPQGTPEVLLDTLAPAHAPLASERALLDIHADGQRIVAPRLSYMEAQRAQRLRLWAERGEFSDVHASALHTSTPTASGAASSTDPLAALQAAYEPPTSSTTTEPASSDAAQVVSKPGTIRESEFVPFRDAMVHQLEVALFHAEQAQNLLGMLIQHSRTEPTNTVLAAQSEYFLDPQSISLSALERALPDEAEPPPPPPLSQRKLVLEEKRASLRRVAALLSQGADELRASHTPERERWLALQQIQRRGWKLTPGRPLMDIERFDTAGTSHHVLQGFGMPVMQGDGSVKEEGARDAWIGYGPSEAPLSVLQRTLAYWADASSSDEAKLAFPDRSWRRLCVQFRDTSQSPPRVWSSASIPEASATDYDAQLYDAQLDAVDMELFRELIAQSGTLSPVLGRTITDHSIELPLSSTLDVRFELVPYGSEDERATSTNLLEADTAWPTLLLHVLRLRMVRGWTRRISALRNTHAAAITVQRPSARSTLMAPLWELYEYTLFLSRLQSFLTKALDHHNTKGTTHATMIWEPYNAIKNVHVWISDLLDVAQDDPQSASPCGGSVLVYVNATYVPVDALRSSMIMQLILRAPSYMVAFFPRHPTPSGLGVRIPLELEQLPSLLLSELAGASASGEASPREAST
Length651
PositionHead
OrganismMalassezia pachydermatis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Malasseziomycetes> Malasseziales> Malasseziaceae> Malassezia.
Aromaticity0.06
Grand average of hydropathy-0.249
Instability index49.37
Isoelectric point5.41
Molecular weight71578.97
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04969
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.83|      15|      15|      16|      30|       1
---------------------------------------------------------------------------
   16-   30 (26.07/13.79)	QAPQGTPEVLLDTLA
   33-   47 (25.76/13.55)	HAPLASERALLDIHA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.94|      46|     213|      94|     145|       2
---------------------------------------------------------------------------
   94-  145 (68.65/44.02)	GAASSTDPLAALQaayepPTSSTTTEPASSDAAQVvSKPGTIRESEFVPFRD
  314-  359 (84.29/40.61)	GYGPSEAPLSVLQ.....RTLAYWADASSSDEAKL.AFPDRSWRRLCVQFRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.67|      11|      17|     248|     262|       3
---------------------------------------------------------------------------
  248-  262 (14.77/18.57)	TPERerwlALQQIQR
  268-  278 (21.90/12.06)	TPGR....PLMDIER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     244.23|      83|     238|     146|     235|       4
---------------------------------------------------------------------------
  146-  235 (117.98/69.92)	AMVHQLEVALFHAEQAQN.....LLGMLI.QHSRTEPTNTVLAAQSEyfLDPQsiSlSALERALP...dEAEpPPPPPLSQRKLVLEEKRASLRRVAAL
  388-  480 (126.26/55.79)	AQLDAVDMELFRELIAQSgtlspVLGRTItDHSIELPLSSTLDVRFE..LVPY..G.SEDERATStnllEAD.TAWPTLLLHVLRLRMVRGWTRRISAL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04969 with Med17 domain of Kingdom Fungi
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