<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04967

Description MED23 (Fragment)
SequenceLNYTLNLIIRLNKQKVDSIDEAFVSVIVFKPQDDKTSNFTNNLITAFGNVENRDHVLRLYLLRTAEASNYHMQVLMGILPKLVDAHLITARLLCDKVLSCEKLDYERKAFWIESFRLIKKVIAQVDYKGVREIMKACRDKAQWFPLSLNVTYLPQLLALEEIIRFIFDRNNCLLPAYFIANEIMRPLPYHWKLNKLMTDFVEEFRTTAQMVSIIGHANMLPIVEHFGYADHLMNSWRLDHNTLKFNFKGSLPYEPELLEAQTPLLRYVLEQPYSREMVSVMLNLQKHQKQRYNALEDQLVNLIIHAMEMTESNDATAGSGFNASDEQITPNEWVWLHLSSQLIYFVLFQFVSFTHIVLALHEKLTKLELRKGRDQLMWILLQFISGSIQKNPITNFLPVFRLFDLLYPEQEPLKLPDYNKSSMVRSMAPICIWIHLMKKARNENMNITRPLPIALKNHNDFLQHLVAPNSIMNIAQSNDFRIILICNAYSTNHDYFARHMNILLDNMNGKSANGAQIPAVTYSVTVLDSLTVHSKMSLIHSFVTQMLKQAQSKTLVPSPALVETYARLLVYTEIESLGIKGFLSQLIPTVFKNHAWGLMHTLMEMFSYRLHHVPTHYRVQLLSLLYSLSTVPQTNKMQLNLCFESTALRLITSIGSAEFQSQFSRFLNDKSAASAASNESEELNRVLILTLARSMHVHGGGDELAGWCKDFLANIMQHTPHSWSMHSLACFPPALKEYFTQNNHPAENKQQLKKSVEEEYLNWTSMSNENDIIAHFIRPNTNPLFLCLLFKIIWETENISPVAYKILEGISARALSTHLRKFCDYLVAEVPSSSDGRDIHKCVDTINSMIWKFNVVTIDRLVLCLALRTHEGNEAQVCFLIIQLLLLKASELRNRVQEFCKDNNPDHWKQNNWHEKHLSFHQKYPEKFAPDESASQIPLPVYFSNVCLRFLPVLDVVVHRFIELTIPNVHQILGYILDHLSILYKFHDRPITYLYNTLHYYERILRDRLPLKKKLVNTITSAFSEIRPANWSVSEPYLAYLQSQDTLWTPELSYYMNLIRRLADTISGKHVFYSTDWRYNEFPNAPTHALYITCVELLGLPLAPAVVAGNIIDVIVTGYAVIPQKEIHSYINAVGIVLAALPEPYWCGIYDRLQEMLNTPNMLNWTYRFNAFELFNFKTVREAMLEKSYAVVLAVAHAVFHHMGAFKLSAITRNIKEKLAPCVRTEQQLIYLCHVFGPFLQRIELEKPNAIAGIAICLYEMLETVDKHHGPKPLEYMDQICDFLYHIKYIHVGNIIKNESEAIIKRLRPLLQMRLRFITHLNLEDIHTDKGGADANSSLTTTTTTATNANQMSQPSPLPAAQQQQHQQQQQQQQQLQQQQQQAATAISSNVSPAVAPTTSLPLGSGGATAQQQLYLQHMQQQQQQQQQQQQQQQQHMQNMGIRHN
Length1445
PositionTail
OrganismDrosophila busckii (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila.
Aromaticity0.10
Grand average of hydropathy-0.151
Instability index44.27
Isoelectric point7.69
Molecular weight166636.53
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04967
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.45|      18|      53|    1365|    1382|       1
---------------------------------------------------------------------------
 1365- 1382 (37.03/18.30)	QHQQQQQQQQQLQQQQQQ
 1408- 1425 (34.15/16.38)	ATAQQQLYLQHMQQQQQQ
 1426- 1439 (24.27/ 9.81)	QQQQQQQQQQHMQN....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.24|      20|     167|     682|     712|       2
---------------------------------------------------------------------------
  648-  667 (33.77/21.04)	LRLITSI....GSAEFQSQFSRFL
  689-  712 (31.46/23.56)	LTLARSMhvhgGGDELAGWCKDFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.77|      13|      16|     605|     620|       3
---------------------------------------------------------------------------
  608-  620 (25.59/15.71)	YRLHHVPTHYRVQ
  626-  638 (23.18/ 6.74)	YSLSTVPQTNKMQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.12|      15|      16|    1072|    1086|       4
---------------------------------------------------------------------------
 1072- 1086 (31.13/19.94)	FYSTDWRYNEFPNAP
 1090- 1104 (26.98/16.23)	LYITCVELLGLPLAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     117.75|      43|     279|     948|     994|       5
---------------------------------------------------------------------------
  157-  222 (53.98/28.35)	LA..LEEI.IRFIF.DRNNCLLpayfianeiMRP........LP....YhwkLNKLMTDFVEefrttaqmvsiIGHAN..MLP.I
  948-  972 (29.98/11.52)	...............................LRF........LP....V...LDVVVHRFIE...........LTIPN..VHQ.I
  973- 1037 (33.79/29.40)	LGyiLDHLsILYKFhDRPITYL......yntLHYyerilrdrLPlkkkL...VNTITSAFSE...........IRPANwsVSEpY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      66.12|      15|      16|     447|     461|       6
---------------------------------------------------------------------------
  447-  461 (26.59/16.27)	ITRPLPI.ALKNHNDF
  465-  480 (16.65/ 7.21)	LVAPNSImNIAQSNDF
  482-  496 (22.87/12.88)	IILICNA.YSTNHDYF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.93|      18|      34|    1272|    1291|       7
---------------------------------------------------------------------------
 1272- 1291 (31.65/24.61)	KPLEYMDqiCDFLYHIKY..IH
 1308- 1327 (28.28/15.33)	RPLLQMR..LRFITHLNLedIH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.29|      11|      32|    1175|    1206|       8
---------------------------------------------------------------------------
 1162- 1172 (23.28/23.08)	MLNWTY............RFNAF
 1184- 1206 (13.01/23.26)	MLEKSYavvlavahavfhHMGAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     255.99|      87|     279|       5|     112|       9
---------------------------------------------------------------------------
    5-  112 (127.18/124.66)	LNLiIRLNKQKVDSIDEAFVSVIV....FKPQDDKTS....NFTNNLITAFGNVENrdhvlrlyllrtaeasnyHM..QVLMGILPKLVD.AHLITArlLCDKVLSCEKLDYERKAFWI
  282-  379 (128.80/84.18)	LNL.QKHQKQRYNALEDQLVNLIIhameMTESNDATAgsgfNASDEQITPNEWVWL..................HLssQLIYFVLFQFVSfTHIVLA..LHEKLTKLELRKGRDQLMWI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.18|      38|      74|     784|     823|      12
---------------------------------------------------------------------------
  784-  823 (59.42/44.70)	LFLCLLFKIiwETENISPVAYKILE..GISARALSTHLRKFC
  861-  900 (59.77/37.34)	LVLCLALRT..HEGNEAQVCFLIIQllLLKASELRNRVQEFC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04967 with Med23 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IHTDKGGADANSSLTTTTTTATNANQMSQPSPLPAAQQQQHQQQQQQQQQLQQQQQQAATAISSNVSPAVAPTTSLPLGSGGATAQQQLYLQHMQQQQQQQQQQQQQQQQHMQNMGIRHN
1326
1445










Molecular Recognition Features






MoRF SequenceStartStop




1) QLYLQHMQ
1413
1420