<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04962

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSGINIKTSTLAKSAGSGGHITMPVSILIPSIEEKNKQMQQETLMEKLRAKYRNKPKSYDEIKKSVRMYFIEKHYPMDPLCKATLQTALDKLQHYIKVSSRHGLVERLESLSRQLGLKFMEDQQLLFISTDMFYVEILLDASGNLNDVKVHHECKIEHQSSSSSSCSELLNCLMAGDFADFTVQLEGLSSIYQLNAEPKVKKKAFVALQAMETDILTIYQQQVKKQMAMGISDSYHIMNSSSVGLVLPRRGGHPLKLTYFCPPLHLIEASGKIKTEKGAPATSRDFSIDQVMRSTNGLNATLNLEASSANKLQILPIVSFTSESGEELDLPRFCVESLQALGLSGSGNSNEGAKGAGSGSTTVMNLIVQTASGHAIKSTQKGLYVNLPKETHCYFFTDNRRLHGTMLTSLPFTEPAQVAKIIAFLKKQALFYTLLSSCVREQQKQYNDMDSTVILEVTAVSLNQITVELQHPYEESLATIDFLLEDSQPKCTIYCLNNDYEALSDKLTRTVRQVLSIPMVIYKLLKCWDEEHQQKLHGIKGSGPGTGAGSGAGSAIGGGLGASGTSNFRQYSKDSSTGTGGDGSYGASGGFNSVNSMKIESRVRSLADAFAASSSAAAAIAGLISLKQEPVPSVSSRNSDQEIADKYKNIWKDKTPNLKHCVSITPIDGDGKAAPQLPQQQQSSEMQRSGGIEIIPLSAPTNMGNSPGAGSTATTITITPITGSTGGGKEASKEARKIASSGTNSLSSSKRPHDSITSSSSSLNPSSSSGSSSSDSQKEKKRKKKRDDSPMGPPEKIYSRQNSPAAGSITDVSTGTGVARKFSSSSASSSPKAGVTGSSTVGMMGGQSTARPSPKHSPVYSSPKHNSNCNTASNSPKSPFGTQSPKHGSSGKPSMSTLKSATAATSLSPKAEKSSTSTLGVNVGSAGSTPASMSLSISQPSTQPSPSSGPNTSMMRSVPPLANSSNSSSQLSMPMKKDKSISSSSTTGIPGSTSGVVAAAVAALKSSQQQHQQLKSSVGSLSHLAAGGNLANFAPSAVSAMEINALRKSMGGSGVGAGAGGAPSSQEGLKLTINKTGSAGGSISATPHKRESKGASSGSLTSASSGKKQHTGLKPGVNSGPASKKGPSNVSQGSSSSKHLFQKANSSGNLSSKLSSSSSGGGLPLIKSNSTNSFQELGAPRRRPSMSSSGGGAGGNVQRKGSFAAPGSAIGGGNFAASLSGSMSQPPPRFDHHTDMMTILQYASPSMAASMEGFIKGLHNKFQIPKLSQRSSGNNSANDASTTSTSAPSTIQSTTATTTSTIGPSPEEQQQKQLNADLSALAASLTASTSSGGGQQKLSSHSDNDLLLNLSNNAGMGSDDGIDEELLARLAGE
Length1373
PositionMiddle
OrganismDrosophila busckii (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila.
Aromaticity0.04
Grand average of hydropathy-0.431
Instability index54.03
Isoelectric point9.41
Molecular weight143077.65
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04962
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.38|      26|      28|     903|     930|       1
---------------------------------------------------------------------------
  899-  926 (31.83/14.72)	KSATAATSLS...PKAEKSSTStlGVNVGSA
  927-  955 (32.56/10.50)	GSTPASMSLSisqPSTQPSPSS..GPNTSMM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.48|      24|      28|    1026|    1053|       2
---------------------------------------------------------------------------
 1041- 1068 (28.62/ 6.20)	MEINALRKSMGGSgvgAGaGG....APSSQEG
 1133- 1160 (22.86/ 8.14)	GSSSSKHLFQKAN...SS.GNlsskLSSSSSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     328.21|      54|      58|    1184|    1238|       4
---------------------------------------------------------------------------
  720-  750 (35.34/ 8.44)	PITGSTGGG....KE......AS..KEARK.I..A.SSGT.....NSLSSSK......................
  788-  844 (49.86/13.45)	...DSPMGP....PEKIYSRQNS..PAA.G.SitDVSTGTgvarkFSSSSAS......SSPKAgvtgSSTVGMM
  845-  893 (38.69/10.03)	......GGQstarPSP....KHSpvYSSPK.H..N.SNCN.....TASNSPKSpfGTQSPKHG....SSGKP..
 1184- 1237 (93.35/37.04)	PSMSSSGGG....AGGNVQRKGS..FAAPG.S..AIGGGN.....FAASLSGS..MSQPPPRF....DHHTDMM
 1245- 1294 (55.54/18.05)	PSMAASMEG....FIKGLHNK....FQIPKlS..QRSSGN.....NSANDAST..TSTSAPST....IQST...
 1296- 1343 (55.44/18.01)	.ATTTSTIG....PSPEEQQQKQ..LNADL.S..ALAASL.....TASTSSGG..GQQ...KL....SSHSD..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     153.95|      37|     533|     561|     598|       5
---------------------------------------------------------------------------
  342-  365 (38.65/14.07)	GLSGSGN.......SNEGAKGAGS.GSTTVMN......
  561-  598 (62.60/31.90)	GASGTSNFRQYSKDSSTGTGGDGSyGASGGFNSVNSMK
 1077- 1107 (52.70/22.17)	GSAGGSISATPHKRES...KGASS.GSLT...SASSGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.69|      27|     222|     751|     780|       7
---------------------------------------------------------------------------
  752-  778 (44.51/15.00)	PHDSITSSSSSLNPSSSSGSSSSDSQK
  977- 1003 (37.18/ 9.83)	KDKSISSSSTTGIPGSTSGVVAAAVAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.85|      31|     336|     680|     711|       8
---------------------------------------------------------------------------
  680-  711 (52.67/28.54)	QQQSSEMQRSGGiEIIPLSAPTNMGN.SPGAGS
 1008- 1039 (49.18/22.71)	QQQHQQLKSSVG.SLSHLAAGGNLANfAPSAVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.77|      45|     220|     197|     245|      11
---------------------------------------------------------------------------
  197-  245 (68.96/63.77)	EP.KVKK.KAFVALQAMETDILT..IYQQQvKKQMAMgisDSYHIMNSSSVGL
  414-  462 (61.81/43.88)	EPaQVAKiIAFLKKQALFYTLLSscVREQQ.KQYNDM...DSTVILEVTAVSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04962 with Med1 domain of Kingdom Metazoa
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