<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04960
Description |
Mediator of RNA polymerase II transcription subunit 18 |
Sequence | MAISSARESLSHALNNRFLPNLEYLLQGSILDSAVEHLMHRLKGLCDNVDTSPETFHDLEVCMSLRQPNTNQPLMLRVRRALGRDAPFQMRYLGQPEVDQRRPTLVRSCMDCACTNGILDFLTEMGFRLEFEYIAKGYMFRKGRMKITVSKLIKIVPGKQDMANEPISQSYIVELSVVAPTGQENVGEEMRVFAEQLKPLVQLEKIDYKRLGNIP |
Length | 215 |
Position | Head |
Organism | Drosophila busckii (Fruit fly) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota>
Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea>
Drosophilidae> Drosophila.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.269 |
Instability index | 54.17 |
Isoelectric point | 7.64 |
Molecular weight | 24533.25 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364150
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP04960
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 44.15| 13| 27| 65| 77| 1
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65- 77 (24.92/13.30) LRQPNTNQ..PLMLR
93- 107 (19.23/ 9.04) LGQPEVDQrrPTLVR
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 41.69| 12| 31| 3| 14| 2
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3- 14 (19.93/12.85) ISSARESLSHAL
31- 42 (21.75/14.52) LDSAVEHLMHRL
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