<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04953

Description Maker316
SequenceMMADHLDEPPQKRVKMDTSDLFFLEDNLPDELVSSNSGWSDQLGGGGGGNGGGSVVSTATGAVSAGVANKPPAQGPGPGVVTAQMNGAGGGNGAGADDGSGNAGAGGGAANQQILNQRQIQHHHLQHLLQQQQQQQQQQQQQQQQQQQQQQQGNKGGGAGGMVVPGMNQLGSKSPNLQSPNTGGMQVAPQMGMVNSMPMSISNNGNNGMNAIPGMNTIAQGNLGNMVLTNSGGGMGNAAGGGGMVNTLKPNAAGMMNTVPGAVNVGVGVGVGAVPGSAPNQAMHMQNGPMMGRMVNMHHMLRGPHLMNTGAAGGNGPGGVVGAGGGPRMQNPNMQLGQINNMPYGVGNYVAPGGQNPQQQQQQQQQQQQLLAQQMAQRGQGGGVVAPNMSAGMPQGGNRPINTVVPMNSLGGDGAPGIVGNPQQQQQQQLSANAQMNPQQQQQAGVQQQQQGGPMGPRAPQPNQLLGHPQQQQQQQQPGTSQQQTVAAGGGVTNADGSAAPAAGSMSDERKKQIQQQLMLLLHAHKCNRRENLNPNREVCSVNYCKAMKAVLAHMATCKQSKDCTMQHCTSSRQILLHYKNCRSGDCIICFPFRQNHLLFQNTGQAGAGQAAAAGGNTLPLQQQQQQQQQQQQVPQGQLQQQQQQQQNAGVGGVVDGKQVVQGAGAGGVQNTAIVLPQQQQQQQTPGAANVPKSNAELAQQQRQQQQQQQQQHPLQQQQELRRFEGVGLGQVGPGVGAGGMLPQQQGMPPGIRMQGGAGGGPAVRVLGVPPSAGGGGGGNLATAGGLPVPVPGQNVIPGGPNDVGSMQQNSQLMQLQGCNASGGRRRTLASLVDQTGAQQQQQQQQQQQQQQQQLGNIPAPLSVNVGFNNANAFVSDKQQQQQQQQQLVGPPDQLAKLKMQAQAHGVPTGATGVAGGAGAGSVLMPADTTGGGNGGANNAGTGGGGGGGGGPAGGAGGTGASGGTPSSGGGPDSEKDWRESVTADLRNHLVHKLVQAIFPTSDPTTMQDKRMHNLVSYAEKVEKDMYEMAKSRSEYYHLLAEKIYKIQKELEEKRLKRKEQQMQQHLLQLQNVPGAPQVPQTLPNNAVQQQQQQQNLSGCCSHPSIHIKRCRQQRAAL
Length1118
PositionTail
OrganismDrosophila busckii (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila.
Aromaticity0.02
Grand average of hydropathy-0.718
Instability index61.12
Isoelectric point9.37
Molecular weight115858.74
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-KW

GO - Biological Function
metal ion binding	GO:0046872	IEA:UniProtKB-KW
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04953
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|    1159.00|     206|     214|      77|     287|       1
---------------------------------------------------------------------------
   25-  206 (308.12/47.13)	..............EDNLPDeLVSSNSGwsdqlGGG....GGGNGGGSVV..............STATGAVSAGVA.......NKPPAQ....GPGP..G.VVTAQ........MN.GAGGGNGAGADDGSGNAGAGGGA....ANQQILNQRQIQ........H..HHLQHL..LQQQQQ...QQQQQQQ..QQQQQQQ..QQQQGNKGGGAGGMVVPGMNQLGSKSPNLQS.PNTGGMQ....VAPQ.MGMVNSMPMSISNNGN
  207-  398 (263.67/42.67)	NGMNAI.PGMNTIAQGNLGN.MVLTNSG.....GGM....GNAAGGGGMVN.TL..KPNAAGMMNTVPGAVNVGVGvGVGAVPGSAPNQamhmQNGPmmGrMVNMHhmlrgphlMNtGAAGGN..GP..G.GVVGAGGGPrmqnPNMQ.LGQ..IN........NmpYGVGNY..VAPGGQ...NPQQQQQ..QQQQQQQllAQQMAQRGQG.GGVVAPNMS...............AGM.......PQ..............GGN
  399-  534 (195.07/26.76)	RPINTV.VPMN...............SL.....GGD....G.APG........................................................IV................GNPQQQQQQQLSANAQMNPQQ....QQQAGVQQQQ.Q........G..GPMGPR..APQPNQllgHPQQQQQ..QQQPGTS..QQQTVAAGGG....V...TNADGSAAPAAGSmSDERKKQ....IQQQlMLLLHAHKCNRRENLN
  546-  686 (178.79/23.82)	KAMKAVlAHMATCKQSKDCT.MQHCTSS.....RQIllhyKNCRSGDCIICfPF..RQNHLLFQNT..GQ..........................................................AGAGQAAAAGG......NT..........................lpLQQQQQ...QQQQQQQvpQGQLQQQ..QQQQQN..AGVGG.VVDG.KQV......VQG.AGAGGVQntaiVLPQ.QQQQQQTP........
  749-  906 (213.35/30.05)	.........................PPG.....IRM....QGGAGGGPAVR.VLgvPPSAGG.....GGGGNLA...TAGGLPVPVPG.................Q........NV.IPGGPN....DVGSMQQ...........NSQLM...QLQgcnasggrR..RTLASL..VDQTGA...QQQQQQQ..QQQQQQQ..QQL.GNI..PAPLSVNVGFNNANAFVSDKQQ.QQQQQQQ....LVGP.PDQLAKLKMQAQAHG.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.70|      19|      23|     910|     932|       2
---------------------------------------------------------------------------
  910-  932 (31.45/15.73)	GA....TGVAGGAGAGsvlmPADTTGG
  936-  958 (35.25/10.95)	GAnnagTGGGGGGGGG....PAGGAGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.16|      28|     387|     687|     714|       3
---------------------------------------------------------------------------
  687-  714 (51.76/20.50)	GAANVPKSNAELAQQQRQQQQQQQQ..QHP
 1075- 1104 (48.40/18.58)	GAPQVPQTLPNNAVQQQQQQQNLSGccSHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.55|      17|      20|    1003|    1022|       4
---------------------------------------------------------------------------
 1003- 1022 (26.61/30.77)	DPTTMQDKR...MHNLvsyAEKV
 1025- 1044 (25.94/18.93)	DMYEMAKSRseyYHLL...AEKI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04953 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVPGSAPNQAMHMQNGPMMGRMVNMHHMLRGPHLMNTGAAGGNGPGGVVGAGGGPRMQNPNMQLGQ
2) GGRRRTLASLVDQTGAQQQQQQQQQQQQQQQQLGNIPAPLS
3) GQAAAAGGNTLPLQQQQQQQQQQQQVPQGQLQQQQ
4) GVGNYVAPGGQNPQQQQQQQQQQQQLLAQQMAQRGQGGGVVAPNMSAGMPQGGNRPINTVVPMNSLGGDGAPGIVGNPQQQQQQQLSANAQMNPQQQQQAGVQQQQQGGPMGPRAPQPNQLLGHPQQQQQQQQPGTSQQQTVAAGGGVTNADGSAAPAAGSMSDERKKQIQ
5) KLVQAIFPTSDPTTMQDKRMHNLVSYAEKVEK
6) LEEKRLKRKEQQMQQHLLQLQNVPGAPQVPQTLPNNAVQQQQQQQN
7) MMADHLDEPPQKRVKMDTSDLFFLEDNLPDELVSSNSGWSDQLGGGGGGNGGGSVVSTATGAVSAGVANKPPAQGPGPGVVTAQMNGAGGGNGAGADDGSGNAGAGGGAANQQILNQRQIQHHHLQHLLQQQQQQQQQQQQQQQQQQQQQQQGNKGGGAGGMVVPGMNQLGSKSPNLQSPNTGGMQVAPQMGMVNSMPMSISNNGNNGMNAIPGMN
8) TAIVLPQQQQQQQTPGAANVPKSNAELAQQQRQQQQQQQQQHPLQQQQELRRFEGVGLGQVGPGVGAGGMLPQQQGMPPGIRMQGGAGGGPAVRVLGVPPSAGGGGGGNLATAGGLPVPVPGQNVIPGGPNDVGSMQQNSQLMQLQGCNA
9) VGFNNANAFVSDKQQQQQQQQQLVGPPDQLAKLKMQAQAHGVPTGATGVAGGAGAGSVLMPADTTGGGNGGANNAGTGGGGGGGGGPAGGAGGTGASGGTPSSGGGPDSEKDWRESVTADL
273
823
609
345
993
1051
1
672
866
338
863
643
515
1024
1096
216
821
986










Molecular Recognition Features






MoRF SequenceStartStop




1) GPAGGA
2) QKRVKMDTSDLFFLEDNLPDELVSS
951
11
956
35