<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04948
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MQREEKHFEITLDAVLQRLVDLKLSVLAMIQKLEMEYMDINWPTFLDNFALISSHLTGLTKILAKEQCPPLRNRTVLPLLVSMDRDEALINLTEGRVPVFSHDIVPDYLRTRPDPVTEQKMQQNEQKASNLTNDAAMKQVTQYNKVVSHVLDMVSKAREEWEIESNSRTGIQQTSSMADTQLLVAAVGMGKGLQFKANYGPGPGMMVPPSIRGPTPPMGGPSMSPGNVQQLGKAPSAVKTNIKSANQVHPFSR |
Length | 253 |
Position | Head |
Organism | Drosophila busckii (Fruit fly) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota>
Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea>
Drosophilidae> Drosophila.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.353 |
Instability index | 38.59 |
Isoelectric point | 7.85 |
Molecular weight | 28120.14 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP04948
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 133.12| 43| 47| 86| 131| 1
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86- 131 (67.02/48.45) DEALINLTE.GRVPVFSHDIVPdylRTRPDPVTEQKMQQNEQKASNL
134- 177 (66.10/39.97) DAAMKQVTQyNKVVSHVLDMVS...KAREEWEIESNSRTGIQQTSSM
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