<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04944

Description Kto
SequenceMLSLLQEKRPLKRTRLGPPDIYPQDAKQREDELTPTNVKHGFTTMPPLSDEFGTAHTTNVNASKVSAFYSGVLAKKEELMTLQDTVRKKQQINCKDNFWPVSPRRKCTVDAWFKDLAGNKPLLSLAKRAPSFNKKEEIFITLCENQVNMQRATWFIKLSAAYTLSFTESKNKKRSIYDPAAEWTSNMIKFMKELLPKLQEYYQQCNNNNSCSNGTSSGSSGGSNNNNSGSNNNNNSSSAISSGNLIPVPSMTSPLPPIHSPANGQPVAVGSAGSGSAAAGATLAPGSTLTPLGGSGVAGGATSANAGAVPPGSSISGVGSQFEDSRNALKYWKYCHQLSKYMYEESLLDRQEFLNWILDLMDKMRTQASFDEPLKKLVLSFAMQYMHDFVQSERLCRKMANLVAKKLAQLLNAAVEQHQQQQALIRAQVMEIDALEESQITQLPNETDSYERALQDCMNCPHHRDIVLYLSTILQVITIECPTALVWSGIAAHRAPSSLVGSPLDHLPLAPSMLPMPTRCQRTNLELRRQLRAAEADIVLRTQHAEQRWFASKWLNAGKNHYTNVLAKLDHLDTHCFERMDQCNSIDTLYAHIFPPQSRRQEEDAQQQQRTAYEPKQDADTVRILCEWAVSSQRWGEHRSIVVAILLDKRQIDVTSTPADLCGDKEDKDSLASGAGLIDGLPVFQHVLMHFLDHDAPVLDEHNSTSQQRTEFTNLMQLFSALIRYDVFSHNAYMHTLISRGDLLLESTLMHKASTATKSSPQPPAPPAASGNASNTHGFDDDGFGAGIGIDFKHNEFDDSNVDDDLDKLVQNIKEKGQQHEAPDSPKIGPPGDADGASVDTHSHSTGNGPGCNISRHYVYTKHFPIPQDDPSMSSYSSESNQRYILLFGVGKERDEKKHAVKKMSKEIGKLFTKKFSIDVAEGGKVKKHSRNEFNFEATTAKCQQMAYFDQHVVTAQCAANVLEQLNGFALGNNNYLPVQEHVAFLFDLMELALNIYSLLELCDQLLKELPEVEHQLQLKKSNMVRGYTTSLALYIVSILRRYHSCLLLSPEQTLSVFEGLCRTIRHVSNPSECSSAERCILAYLSDLHESCVLLQSKEQSSEYYQQLNCIKRFKDIFNTPEQLLPHSLAPQGYNPQMLQELFVAPRRGGKLEPHWLRQLHESSANVYSFVSNAVIAVCRETDNERLNDVALACAELTASCNVLSEEWIAALQSLCSGSKNPRYPHLNNQVDIGQTKTHNALAVFVCILVARHCFSLADFVSKFALPTLARSVSGGGELSSDAEAGARLTCHLVLKLFKTLEIPQPGMYSVSTSPNPLHAVGNDFSIRLSCDRHLLVGAHKTIPIAAVLAVLKAILIVVDNAALKTPLSGNGGLGSAGSSTGGGVGSGSFSSGKRSGFNTPVHPGSTPKSNEQRPADLSQILGTSDLQLGSLGNEQESLQQSSSGNSLGSGEQISLLEFAQAVLKQICAQEHVLERCLKNAEQLCDMIIDEMLTAKQAQRVLHMICYPEAEFNIISELDQRAMIVRILEQLDQWTLRISWLDLQLMYRQSLSNPSELNIWLDTVARAAIDVFHMEEIMLPGAVKPIHKPKPSTWLVAPLIAKLTPAVQGRILRVAGQVLESMNYFSKVSKSDCNSSGSGDEREKGNSCHSSNSFGGGAGGANGGSSSNGNAAPRNKKMPLNYQPFLGLILTCLKGQDEYKEQLLVSLYSQLSQCLQSFAEVSFDFKPFDIFNSIVFSLQLDTIGGIDEPQAREEILDALQLRFSLVGGMFEAIQKNSTPTTDWAILLAQLVCQGVVDLSCNRELFTTVVDMLATLVHSTLVSDSQSERDENKKLYLNLMKKLKKEIGEKNNASIRVIRQLLPLYKQPTEVIACEHAGMDTKGNKICDMDKKQLRISDKQRISVWDILEGHKNPAPLSWVWFGAVKLERKPLTYEEAHRNLKYHTHSLVKPSSYYYEPLPLPPEDIEPVPEKICIKDEIMKADTPSSVDQSPSAVVGTGRGRGKGTTTRKRKPKNPKTPPVVNTQQQQPQLVPQPQQPQNPQQQQQMQQQQHQQQQQQHMQQQMQPNMGQMPMQMQQMNMQQFGPNAMMQQQNALMQQQQQQQQQQQQMQQMAPNQMQQQLNVGPNGQQAQMNFMQGPGGPVGPQGMPGQQQQQPQWHNAPQQQQQQQQPQQYHQQYTHQQNIQSIRMDRPPVNANSKQALSQMLRQRQPASFQQQQQQQQQQQPPGGGFNPLQQQQQQQQQAPQQQQQLSAQQMRQQQQQMNAQQNPQAAAAAAAAFSAMQQQQNVQQQQQMNPNQQQQMNPNQQQQQMNPNQQQQFMRNNMRAMAPNQMSGMNMVGQGIPQNPMMQQQPMGQGMVGMVNPNANPMMQGAGSGNGSVGVGVGVGGGGNNMSMGGMPQQGMMQQQQQVQFQNFQNQYQQQQQQGMQQQGGGAGVGVGVGVGMGPNQQQQQQAGLMGNFNPQMQQAQRNNPDFMAAAVAAQQQQRGVPGGMMAANRGQYMNQAPNVTMTNMMGPGPGVGVGQVPPYARQQSTGGGKPGVLPSQQQFQQQQQQLRHQQMMQMQGMGGGGMGGGPQAVGGGGAGGGGMVQQQQNMNQQQTPNLVAQLQRQMPNQPNMMGQQQQYQHQPPPY
Length2627
PositionKinase
OrganismDrosophila busckii (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila.
Aromaticity0.06
Grand average of hydropathy-0.569
Instability index54.70
Isoelectric point7.34
Molecular weight290631.44
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04944
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     171.89|      15|      15|    2285|    2299|       1
---------------------------------------------------------------------------
 2039- 2053 (28.96/ 8.91)	N.PQQQQQMQ....QQQ.HQQ
 2058- 2076 (24.37/ 6.05)	H.MQQQMQPNmgqmPMQ.MQQ
 2105- 2119 (26.32/ 7.26)	Q..QQMQQMA....PNQmQQQ
 2254- 2268 (26.27/ 7.22)	M.RQQQQQMN....AQQ.NPQ
 2285- 2299 (35.68/13.09)	N.VQQQQQMN....PNQ.QQQ
 2301- 2316 (30.29/ 9.73)	NpNQQQQQMN....PNQ.QQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     138.53|      15|      15|    2209|    2223|       2
---------------------------------------------------------------------------
 2154- 2168 (29.79/ 9.74)	P.QWHNAPQQQQQQQQ
 2209- 2223 (30.55/10.22)	P.ASFQQQQQQQQQQQ
 2225- 2240 (25.35/ 6.94)	PgGGFNPLQQQQQQQQ
 2414- 2427 (27.35/ 8.20)	N.Q.YQQQQQQGMQQQ
 2581- 2595 (25.49/ 7.03)	G.GGMVQQQQNMNQQQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.62|      12|      15|     260|     271|       4
---------------------------------------------------------------------------
  260-  271 (22.75/13.70)	SPANGQPVAVGS
  276-  287 (20.87/11.76)	SAAAGATLAPGS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.14|      14|      15|    1639|    1652|       5
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 1639- 1652 (26.72/13.94)	GDEREKGNSCHSSN
 1655- 1668 (25.42/12.88)	GGGAGGANGGSSSN
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     395.06|      53|      53|    2334|    2386|       6
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 2079- 2120 (41.73/10.44)	MQQFGPN.................A.......................................................MMQQ......QNA......LMQQQQQ...QQQqqqqmqqmapnqmqqqL
 2334- 2355 (31.50/ 6.12)	...............................................................................NMVGQ...GIPQNP......MMQQQPM...GQG................M
 2356- 2406 (87.42/29.73)	VGMVNPN.................ANPMMQ..............GAGSGNGSVGVGVGVGGG...............gnNMSMG...GMPQQG......MMQQQQQ.......................
 2407- 2453 (56.20/16.55)	VQFQN.F......................QnqyqqqqqqgmqqqGGGAGVG.VGVGVGMG................................P......N.QQQQQ...QAG................L
 2454- 2517 (54.68/15.91)	MGNFNPQmqqaqrnnpdfmaaavaAQQQQR..............G.........VPGGMMAA.................NR.GQ...YMNQAPnvtmtnMMGPGP....GVG.................
 2518- 2556 (60.18/18.23)	VGQVPPY.................ARQ..Q..............STGGGKP..GV.................................LPSQQ......QFQQQQQqlrHQQ................M
 2557- 2621 (63.36/19.57)	MQMQG.......................MG..............GGGMGGGPQAVG.GGGAGgggmvqqqqnmnqqqtpNLVAQlqrQMPNQP.....nMMGQQQQ...YQ..................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.03|      10|      15|    1479|    1488|       7
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 1479- 1488 (18.42/11.39)	KNAEQLCDMI
 1496- 1505 (17.61/10.51)	KQAQRVLHMI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.43|      13|      17|    1425|    1439|      10
---------------------------------------------------------------------------
 1425- 1439 (19.03/17.37)	SDLQLGSlgNEQESL
 1444- 1456 (23.40/13.30)	SGNSLGS..GEQISL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.43|      12|      15|     724|     735|      13
---------------------------------------------------------------------------
  724-  735 (23.74/17.74)	RYDVFSHNAYMH
  740-  751 (20.69/14.36)	RGDLLLESTLMH
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.61|      14|      15|     648|     661|      16
---------------------------------------------------------------------------
  648-  661 (23.77/17.31)	DKRQIDVTSTPADL
  664-  677 (22.84/16.27)	DKEDKDSLASGAGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.51|      17|      20|    1732|    1748|      20
---------------------------------------------------------------------------
 1732- 1748 (29.36/20.36)	NSIVFSLQL..DTIGGIDE
 1753- 1771 (24.15/15.21)	EEILDALQLrfSLVGGMFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.22|      14|      15|    1309|    1322|      21
---------------------------------------------------------------------------
 1309- 1322 (25.24/13.57)	YSVSTSPNPLHAVG
 1325- 1338 (24.99/13.37)	FSIRLSCDRHLLVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.11|      35|     185|    1670|    1706|      23
---------------------------------------------------------------------------
 1670- 1706 (59.49/41.86)	NAAPR..NKKMPLNYQPflGLILTC......LKGQ...DEYKEQLLVS
 1851- 1896 (46.61/26.13)	NASIRviRQLLPLYKQP..TEVIACehagmdTKGNkicDMDKKQLRIS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04944 with Med12 domain of Kingdom Metazoa
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