<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04943

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMTEEWQSQNFRQNIITKIHDIIPHNGIEPHKNASVMESHIFRKSRTKDEYLGLVAKLFMHYKDMSRKSQAQQQQQMQQQQQQQPQAPPQGAEMGQQNMMQDPLNALQNLASQGNRNPQLMPMGGAAGPNQMAGPGGGQGGVPASNLLQTLNQQRPGQQQMQPMLNIRGQLPMGAAGGQQMVQVQQMGGNGPNGGVQMNAMGPGGVPNQAQLAGNAGGGGMPNQMVGPGPNSGPAGAPAGGMPNQMSNMVQLGMNPMLRNIQGMQGIPANMQQQHNVVGGPGGQQQVGAPVGMPPNAQAPGMNPMGGMNVNMPPNMQQKPNMGMAQNPQMFAANRGGVVGAQQQQGQPFMRSSPSPADAQQLQQQQQLQQQLQQQQQQVQQQQLVGNQTPIQQPNTPQMPTPQMIPSPALVPQSSPQMMMQNSQRSIRQQSPSASINTPGQVTGNSPFNPQEEALYREKYKQLTKYIEPLKRMLSKISNDGTNVDKMTKMSKLLEILCNPAQRVQLDTLLKCEKALEKMDLLSYSGQQFGKSSNPLLEVINTTLQSNVANHTLHRTFRPSLELLFGTDICAPVPAKKQRIEKKCSPFEQDVPHVLQGEIARLDSKFKVKLDTTAQNNNKAIKLICCLDDKRLPSVPPVSVSIPEEYPWQSPDCALTEQEYTATPFLRTVQQALIARMSKLPKNYSLSHLLDTWEMAVRQACSPQSKPRALCELSTLLGV
Length718
PositionTail
OrganismDrosophila busckii (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila.
Aromaticity0.03
Grand average of hydropathy-0.669
Instability index68.21
Isoelectric point9.40
Molecular weight78397.82
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04943
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     333.36|      49|      49|     333|     381|       3
---------------------------------------------------------------------------
   58-   92 (41.39/ 7.02)	.............FMH.Y.....K..........DMSRKSQAQQ.QQQMQQQQQQQPQA......pPQ...GAE
   93-  125 (39.94/ 6.47)	MGQQ...N......MM.Q.....D...PLN...A.LQNLASQGNRNPQL...................mpmGGA
  156-  205 (56.72/12.87)	.G.....QQQMQPMLNiR.....G...QLPmgaAGGQQMVQVQQMGGNGPNGGVQMNAM.......GP...GGV
  234-  279 (54.55/12.05)	AGA....PAGGMPNQM.SnmvqlG...MNP...M.LRNIQGMQGIPANMQQQ......H.......NV...VGG
  338-  383 (83.88/23.24)	VGAQ...QQQGQPFMR.S.....S...PSP...ADAQQLQQQQQLQQQLQQQQQQVQQQ.............QL
  384-  441 (56.88/12.93)	VGNQtpiQQPNTPQMP.T.....PqmiPSP...A....LVPQSSPQMMMQNSQRSIRQQspsasinTP...GQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     154.76|      43|      82|     569|     611|       5
---------------------------------------------------------------------------
  526-  561 (33.11/17.06)	........QQFGKSSNPLLEV...INT...TLQSNVANhtLHRT....FRPS..LE.
  569-  611 (73.78/47.69)	CAPVPAKKQRIEKKCSPFEQD...VPH...VLQGEIAR..LDSK....FKVK..LDT
  638-  691 (47.87/28.18)	SVSIPEEYPWQSPDCALTEQEytaTPFlrtVQQALIAR..M.SKlpknYSLShlLDT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04943 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KDMSRKSQAQQQQQMQQQQQQQPQAPPQGAEMGQQNMMQDPLNALQNLASQGNRNPQLMPMGGAAGPNQMAGPGGGQGGVPASNLLQTLNQQRPGQQQMQPMLNIRGQLPMGAAGGQQMVQVQQMGGNGPNGGVQMNAMGPGGVPNQAQLAGNAGGGGMPNQMVGPGPNSGPAGAPAGGMPNQMSNMVQLGMNPMLRNIQGMQGIPANMQQQHNVVGGPGGQQQVGAPVGMPPNAQAPGMNPMGGMNVNMPPNMQQKPNMGMAQNPQMFAANRGGVVGAQQQQGQPFMRSSPSPADAQQLQQQQQLQQQLQQQQQQVQQQQLVGNQTPIQQPNTPQMPTPQMIPSPALVPQSSPQMMMQNSQRSIRQQSPSASINTPGQVTGNSPFNPQEEAL
2) QNIITKIHDIIPHNGIEPHKNASVMESHIFR
62
12
454
42










Molecular Recognition Features






MoRF SequenceStartStop




NANANA