<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04937

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMTILYKVAKSRELSNNKEKDSVFPHKVVLCSVSSRNIIAYSSLQNLSSHVYVCDIVTPWQYYKVCTSKSLINVLEWSANGEQLLLGYIGGRVEIWQPKEHALNIWQLEYFAVVPSEDIIAAKFFHNGKGVIFNTQKKDHTYYAEKFERLEQRPTLTGFGGVATEGCILLTSSGLLAAFTLPQLQKLPPNSGNNSTSEPLSLNMNEQVIELTPSTHSIGISRSYIEHCSIMPASGTVNIAYTVGWQQQQQLVHCFKVSLNLDVDRIGIKSESLASIFLSSGALPLESRRIAQLLWTRVANDDVIFVVYSCPDGSNLLEQWTLTRRHQNVHALLQQSSNAGSNNKSDLLTSESWDQVAKLQLNAAVSQLCSTRLVSVDCAQLFVILQDNSVQVLEPGTLKQLNHTQFERESEARFVCADLTPSSQMLLIFDSQAQLHAMQTPLLKQNTALNQLLLLLFEYCIVTGVDASDVLLLNLGNLEALVEKLTDNFTRQPSYVRQFYYANFLALKSNLCRAQQQEFDNLIILHAISSTFKSLLRPSDLSCQDKGPADNLAMKLADSVPDVDTVMLNVDPKDFTVEPMILQSLQQLIQWVTDLALNMLSRLPEEVMKSKLSGKRPSYDISRDIVAIGSLRELLVMIRIWGLLNAQCLPVYTKTMDNIDVLVILFRLLTRLSQNTAEPDELLLDECSLLSKQLLIPQLSKYNPTTLLSAQGFAAVKSGQLTFTSLVEPAGLHDIEMEQVVFFNCKKDGVSNLQLGARPSTIRSCARCGFVNSANKVAKTSALKAWCNKWLHCHCGGFWQHVN
Length802
PositionTail
OrganismDrosophila busckii (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila.
Aromaticity0.08
Grand average of hydropathy-0.015
Instability index43.48
Isoelectric point6.30
Molecular weight89557.95
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04937
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.08|      55|      69|     432|     486|       1
---------------------------------------------------------------------------
  432-  486 (87.26/64.53)	AQLHAMQTPLLK.QNTALNQLLLL.LFEYCIVTGVDASDVLLLNLGNLEALVEKLTD
  501-  557 (81.82/59.98)	ANFLALKSNLCRaQQQEFDNLIILhAISSTFKSLLRPSDLSCQDKGPADNLAMKLAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     190.01|      65|      74|     268|     338|       2
---------------------------------------------------------------------------
  268-  338 (93.51/96.10)	KSESLASIFLSSGA.LPLESrRIAQLLWTRVANDDV..IFVVYScpDGS.NLLEQWTLtrRHQNvHALLQQSSNA
  343-  411 (96.50/72.60)	KSDLLTSESWDQVAkLQLNA.AVSQLCSTRLVSVDCaqLFVILQ..DNSvQVLEPGTL..KQLN.HTQFERESEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.53|      22|     513|     167|     188|       3
---------------------------------------------------------------------------
  167-  188 (37.54/20.69)	ILLTSSGLLA.AFTLPQLQKLPP
  641-  656 (21.66/ 8.91)	......GLLN.AQCLPVYTKTMD
  681-  703 (32.33/16.83)	LLLDECSLLSkQLLIPQLSKYNP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04937 with Med16 domain of Kingdom Metazoa
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