<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04900

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAMTIKEKRQRPTPFTATSAWDASLGWHSRLLAAAKLGNQQPQSGAAWMSNSSKMTTNGGSLEDCHTNVFALTELNGLKWKCLTTPLSQRTWTSLEHDPVLSAYAKCLQAGILCAWRRQPPQPSSALTALPLPDYRIDVVKELWVFWYSQEEPECLAQYTSHLSCKSAFEGGEDGQGNWSVPGIQYETRTLFFKXGDMESDHDLINGLSISGEDGQGNWSVPGIQYETRTLFFKALHNLIERNLLKNGYIRIGKYFARPYEVPSADRVQCSPSYITGISFNFFVHGENTVCTSVNIQRQPTLFRLSRRHLDRGKRQPVILGPWSLRAHLLPDQPRIVTMPVPASHPAFANDGGFPSMEMNKPGVSSLGAARCEPPFGAHQSAVLPCSSSAANNMSSVNTADMHNTIAKETVDKLWTEWLQFFALPYTEKTTRDDLMENMGYIEANDKEQIDSSDMPKMVMVDVDGVRMWYPSALIVVQASDDLLLRSEEGESSEEELENLAARVHMTNSSNTSAMRATTPISLRKRQRKHRETELDGPNGERRNMMYNTMVNGARAAQRFFEEACILPSSARRRESMGSPASSGLGLLISGGNNDDDTRWNLTDGMRRKEREHEHCSCRQCQVASSSRAQMSSVASTSGVSSQSATPQHGTPQPTRVPTPCGNGGDETAPGTPKEAFVLFHRRSPSCARSPSPPRSPFWEERLSSLINEPVDSERGSPDWIHESVAHGSSLSSSRSARLELNQGGRCFAYCCDVCIRAFVLFHRRSPSCARSPSPPRSPFWEERLSSLINEPVDSERGSPDWIHESVAHGSSLSSSRSARLELNQDDRYQYPESPSGGTPESPDYRKVHRKRLGSSLSKPANCKPVYQNLSPSTSRPRSPVTGVPQASGTLGRFLSSGCLNAHCFSPLNVPPESGRGNDEMISKKLIKVEVGDLTSIRTGCLEQRVLPKDREFQKPRRRKDRLVSRKLKWNTIDLLDVSYVAREIGEDDRSGDLLMDEPMVTVKAEPVEAGESECAAGSQMTSTANTQPSNTPTGSAAMQHPQLLSSSAPSCLPVYSQGLSVPNTSSGITMPGSSGGLGSDVYGVDSDAQFLDDCSPSTVAMMDTSSPVEPVTDSVHLSPPASNERVEPQTICSSLGSAVTNNLLARVGGPPSVGDYMIYPTPPSVDATQSQPFSPQNILVQSNGANTIYPPSAAPFMMQPFTTATNICHTLPPQLLPNTIHDVETCENLVAIKKEIENEEERIDKKPQEKLERLLSEKPVYGDVKKIEIALSGKFAGDIFRGEPLPLEFFIGSSIELFDLSFCWCNEQCFYFSQLKNYRMPQAVYADQVKLVNAALAVRSKRKRVGRPPDYMVLRERTAQVTQNSTPRLPHYRLNYNPTQMCSSNIPNIQASTSMAAPICGSQPSNVVSASSASGFMGTGSGPMVSNGGGSGMMGMMMAGTNTGMVHSGGAPMHSMIGGPPSMGMQSMNAQMNMAQLRTPGRPQSLSYAPAPTAPGQHHGGGFMGQPQYGVPPSMMSAPGQMGPMHNGRMGPGSMGGPPAPQGLGMMQPGQAPPMMVGGPNSGAPMMHPQMQSQQQPFQQLSQFVNNTNFAGQQVPPGMNPQQQQQQMFQQQLLYRSNMAGSTTPQQSINSPGGYMMDSQASTPIEPPPPFSQAISGRYSNSPSGSATPSVYSQSPQMMRSGSLMAQTNAQGGAMMLGPRTPQSAMLMQAAVNSPMSNQIYPGRPMGMQQMMDISSTTAIRAHPEGKSLVLAVLLQDTVLDLHYDSVFDACPICSCNGNIRAKELGVYITPPEVLRQPPAQQQIIVSKPTSGFYNNTSNPCNCGFSAVRHRYLSMKAGLFPEDAKEATDISENQTQPVIPHTIWFDSMSGRDMNFIALLREQTLVRDLGGIVQQVTMLSIQCERAAQFERIGSDSSEPTEYIISEVDQRELPLVFQAACEVACMEMNCRRPPHDNRSVVMHDWGVQIANEMREPREAECLAVLHEVGPVLEETLRIARSAPLVGSNNIVEGPLTWRFFDRKSLKTGSGMEDDSAPEPVPNVLVASERDVITASPQILRMWEKMTLEPYDQPKDVLYIAVVPDSLVCVEKSKKYFDDLSRIYEQCRFGRHIPFAREPFKDGMLRVPARFPSTNPGECDNFLNQVERHMGDNKTLIARLKAYMQCFENEVSRVLLNSDCIFTRDTYRTLIVEHQAQSGLLSSTNVAFQPGAVPVASGSSEQMPPPAAPSSVCSNVQLGDTPQGPNSAGPGSVGPTSAGCSGEPLTPDNVVSGEAAAQAGTTTSSLLAEQVVDGVIPDDEPGTLPQVIVLYLVNPFLMGSEENPLVARVVTVALMRAFNALLYRLNVRRRPQLQLEIVGLQSIFDYTSTCADFLKDERGRLNAFDQGRMEKTLNERLSSADSLKTVALSVYSQSRIVLADVVRGILPKSMTRFGPASAMGDLLGDLDKKEPTFYKVPCKPFILAPPPPVMQRSSGDIMQINTDETVLFVSYCLIGNDWLAATVTDHQGHLLDNCLINLRLKPDHKRVNMRYKQSTQIRDSLYRLWSYILGTLATGTKNWRLVIGRVGRIGHGEFKFWTQLLSKSYLKQVGSRMKHACRSCHMMPGTAETPGVLSACLVSLEPEAHLRIFPSSFQHDERFVKNARYRTLTTPDDCSCTHILVFPTSPELNLDHQGGSGAAELEEDDFSNLLTEEIGEEFSDLIGNGEDLISNASGPPPQSAGFRIGGNTGIPSEYADVSIENQPLATGYYVSTAPASELPDWFWSACPSAKRRNPVHLKSSLHLNTPNVQQGDDISSFGAKSSETSHHQLDSQATVDVLRYVLETYNALSWLNMDFVTGERRSCLPVHIQALMRLCNTANRLIN
Length2861
PositionMiddle
OrganismAscaris lumbricoides (Giant roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Ascaridomorpha> Ascaridoidea> Ascarididae> Ascaris.
Aromaticity0.07
Grand average of hydropathy-0.409
Instability index57.15
Isoelectric point6.09
Molecular weight313328.01
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04900
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     434.29|      74|      81|     676|     750|       1
---------------------------------------------------------------------------
  676-  704 (40.31/14.69)	.......................................................AFVL.FHRR..S.PSCA......RSP......SPPRS.PFWEERLS
  705-  786 (138.98/77.76)	SLINEPVDSERGSPDWIHESV..AHGSSLSSSRSARLELNQGGRcFAYccdvcirAFVL.FHRR..S.PSCA......RSP......SPPRS.PFWEERLS
  787-  854 (116.26/59.84)	SLINEPVDSERGSPDWIHESV..AHGSSLSSSRSARLELNQDDR.YQY................peS.PSGG......TPE......SPDYR.KVHRKRLG
  855-  892 (49.51/20.37)	SSLSKPANCK...P.............................................vYQNL..S.PSTS......RPR......SPVTGvPQASGTLG
  906-  943 (32.26/ 9.93)	SPLNVPPESGRGNDEMISKKLikVEVGDLTSIRTGCLE...............................................................
 1116- 1176 (56.95/24.77)	VHLSPPASNERVEPQTIC........SSLGSAVTNNLLARVGG........................pPSVGdymiypTPPsvdatqSQPFS.P.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.89|      23|      39|     172|     194|       2
---------------------------------------------------------------------------
  172-  194 (53.45/28.54)	GEDGQGNWSVPGIQYETRTLFFK
  212-  234 (53.45/28.54)	GEDGQGNWSVPGIQYETRTLFFK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     320.67|      28|      29|    1516|    1543|       3
---------------------------------------------------------------------------
 1413- 1442 (28.89/ 8.18)	..SASGFMgtgsGPMV..SNG.G.......GSGMMGMMM..AGT
 1446- 1464 (25.61/ 6.34)	MVHSGG......APMH..SMI.G.......GPPSM.........
 1487- 1514 (30.85/ 9.28)	LSYAPAPT....AP.....GQhH.......GGGFMGQPQygVPP
 1516- 1543 (59.68/25.45)	MMSAPGQM....GPMH..NGR.M.......GPGSMGGPP..APQ
 1547- 1571 (40.53/14.71)	MMQ.PGQA....PPMM..VG..........GPNS.GAPM.mHPQ
 1572- 1598 (30.90/ 9.30)	MQS...QQ....QPFQqlSQF.V.......NNTNFAGQQ..VPP
 1600- 1627 (36.99/12.72)	MNPQQQQQ....QMFQ..QQL.L.......YRSNMAGST..TPQ
 1629- 1654 (32.64/10.28)	SINSPG......GYMM..DSQ.A.......STPIEPPPP..FSQ
 1672- 1704 (34.58/11.37)	VYSQSPQM......MR..SGS.LmaqtnaqGGAMMLGPR..TPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.83|      27|      29|    1047|    1075|       4
---------------------------------------------------------------------------
 1019- 1054 (42.06/20.05)	SQMTSTANTQPSNTPTGSA..amqhpqllsSSA...PSCLP
 1057- 1097 (36.77/11.57)	SQGLSVPNTSSGITMPGSSgglgsdvygvdSDAqflDDCSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.48|      25|      44|    1887|    1911|       5
---------------------------------------------------------------------------
 1887- 1911 (42.83/32.71)	RDLGGIVQ...QVTMLSIQCERAAQFER
 1930- 1957 (42.65/32.53)	RELPLVFQaacEVACMEMNCRRPPHDNR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.47|      40|      44|     324|     367|       6
---------------------------------------------------------------------------
  324-  367 (65.18/41.04)	SLRAHLLPDQPRIvtmpVPASHPAFANDGGFPSMEMN....KPGVSSL
  371-  414 (64.29/31.98)	RCEPPFGAHQSAV....LPCSSSAANNMSSVNTADMHntiaKETVDKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     158.20|      48|     806|    1771|    1824|       7
---------------------------------------------------------------------------
 1771- 1824 (75.37/54.39)	ACPICSCNGNiRAKELGVyITPPEVLRQPPAQQQIIvskPtSGF...........YNNTSNPCNC
 2594- 2652 (82.84/41.61)	ACRSCHMMPG.TAETPGV.LSACLVSLEPEAHLRIF...P.SSFqhderfvknarYRTLTTPDDC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.60|      37|      37|     472|     508|       8
---------------------------------------------------------------------------
  469-  506 (55.14/35.87)	WYpSALIVVQASDDLLLRSEEGESSEEELE..NLAARVHM
  507-  546 (53.46/34.52)	TNsSNTSAMRATTPISLRKRQRKHRETELDgpNGERRNMM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     283.87|      94|     895|    1196|    1295|      10
---------------------------------------------------------------------------
 1196- 1295 (150.86/107.36)	PFMMQPFTTAtnicHTLPPQLLPNTihDVETCEN.LVAIKKEIENEEERIDK.KP.....QEKLER.LLSEKPVYG.DVKKIEI....ALSGKFAGDIFRGEPLPLEFFIGSS
 2112- 2218 (133.02/80.19)	PFAREPFKDG....MLRVPARFPST..NPGECDNfLNQVERHMGDNKTLIARlKAymqcfENEVSRvLLNSDCIFTrDTYRTLIvehqAQSGLLSSTNVAFQPGAVPVASGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.18|      16|     241|    1469|    1484|      11
---------------------------------------------------------------------------
 1469- 1484 (32.11/16.84)	MNAQMN..MAQLRTPGRP
 1709- 1726 (27.06/13.02)	MQAAVNspMSNQIYPGRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.44|      17|      17|    1379|    1395|      12
---------------------------------------------------------------------------
 1363- 1378 (21.86/ 8.60)	.TQNSTPRLPHYRLNYN
 1379- 1395 (30.86/15.52)	PTQMCSSNIPNIQASTS
 1399- 1412 (23.72/10.03)	P..ICGSQPSNV.VSAS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04900 with Med13 domain of Kingdom Metazoa
Unable to open file!