<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04900

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAMTIKEKRQRPTPFTATSAWDASLGWHSRLLAAAKLGNQQPQSGAAWMSNSSKMTTNGGSLEDCHTNVFALTELNGLKWKCLTTPLSQRTWTSLEHDPVLSAYAKCLQAGILCAWRRQPPQPSSALTALPLPDYRIDVVKELWVFWYSQEEPECLAQYTSHLSCKSAFEGGEDGQGNWSVPGIQYETRTLFFKXGDMESDHDLINGLSISGEDGQGNWSVPGIQYETRTLFFKALHNLIERNLLKNGYIRIGKYFARPYEVPSADRVQCSPSYITGISFNFFVHGENTVCTSVNIQRQPTLFRLSRRHLDRGKRQPVILGPWSLRAHLLPDQPRIVTMPVPASHPAFANDGGFPSMEMNKPGVSSLGAARCEPPFGAHQSAVLPCSSSAANNMSSVNTADMHNTIAKETVDKLWTEWLQFFALPYTEKTTRDDLMENMGYIEANDKEQIDSSDMPKMVMVDVDGVRMWYPSALIVVQASDDLLLRSEEGESSEEELENLAARVHMTNSSNTSAMRATTPISLRKRQRKHRETELDGPNGERRNMMYNTMVNGARAAQRFFEEACILPSSARRRESMGSPASSGLGLLISGGNNDDDTRWNLTDGMRRKEREHEHCSCRQCQVASSSRAQMSSVASTSGVSSQSATPQHGTPQPTRVPTPCGNGGDETAPGTPKEAFVLFHRRSPSCARSPSPPRSPFWEERLSSLINEPVDSERGSPDWIHESVAHGSSLSSSRSARLELNQGGRCFAYCCDVCIRAFVLFHRRSPSCARSPSPPRSPFWEERLSSLINEPVDSERGSPDWIHESVAHGSSLSSSRSARLELNQDDRYQYPESPSGGTPESPDYRKVHRKRLGSSLSKPANCKPVYQNLSPSTSRPRSPVTGVPQASGTLGRFLSSGCLNAHCFSPLNVPPESGRGNDEMISKKLIKVEVGDLTSIRTGCLEQRVLPKDREFQKPRRRKDRLVSRKLKWNTIDLLDVSYVAREIGEDDRSGDLLMDEPMVTVKAEPVEAGESECAAGSQMTSTANTQPSNTPTGSAAMQHPQLLSSSAPSCLPVYSQGLSVPNTSSGITMPGSSGGLGSDVYGVDSDAQFLDDCSPSTVAMMDTSSPVEPVTDSVHLSPPASNERVEPQTICSSLGSAVTNNLLARVGGPPSVGDYMIYPTPPSVDATQSQPFSPQNILVQSNGANTIYPPSAAPFMMQPFTTATNICHTLPPQLLPNTIHDVETCENLVAIKKEIENEEERIDKKPQEKLERLLSEKPVYGDVKKIEIALSGKFAGDIFRGEPLPLEFFIGSSIELFDLSFCWCNEQCFYFSQLKNYRMPQAVYADQVKLVNAALAVRSKRKRVGRPPDYMVLRERTAQVTQNSTPRLPHYRLNYNPTQMCSSNIPNIQASTSMAAPICGSQPSNVVSASSASGFMGTGSGPMVSNGGGSGMMGMMMAGTNTGMVHSGGAPMHSMIGGPPSMGMQSMNAQMNMAQLRTPGRPQSLSYAPAPTAPGQHHGGGFMGQPQYGVPPSMMSAPGQMGPMHNGRMGPGSMGGPPAPQGLGMMQPGQAPPMMVGGPNSGAPMMHPQMQSQQQPFQQLSQFVNNTNFAGQQVPPGMNPQQQQQQMFQQQLLYRSNMAGSTTPQQSINSPGGYMMDSQASTPIEPPPPFSQAISGRYSNSPSGSATPSVYSQSPQMMRSGSLMAQTNAQGGAMMLGPRTPQSAMLMQAAVNSPMSNQIYPGRPMGMQQMMDISSTTAIRAHPEGKSLVLAVLLQDTVLDLHYDSVFDACPICSCNGNIRAKELGVYITPPEVLRQPPAQQQIIVSKPTSGFYNNTSNPCNCGFSAVRHRYLSMKAGLFPEDAKEATDISENQTQPVIPHTIWFDSMSGRDMNFIALLREQTLVRDLGGIVQQVTMLSIQCERAAQFERIGSDSSEPTEYIISEVDQRELPLVFQAACEVACMEMNCRRPPHDNRSVVMHDWGVQIANEMREPREAECLAVLHEVGPVLEETLRIARSAPLVGSNNIVEGPLTWRFFDRKSLKTGSGMEDDSAPEPVPNVLVASERDVITASPQILRMWEKMTLEPYDQPKDVLYIAVVPDSLVCVEKSKKYFDDLSRIYEQCRFGRHIPFAREPFKDGMLRVPARFPSTNPGECDNFLNQVERHMGDNKTLIARLKAYMQCFENEVSRVLLNSDCIFTRDTYRTLIVEHQAQSGLLSSTNVAFQPGAVPVASGSSEQMPPPAAPSSVCSNVQLGDTPQGPNSAGPGSVGPTSAGCSGEPLTPDNVVSGEAAAQAGTTTSSLLAEQVVDGVIPDDEPGTLPQVIVLYLVNPFLMGSEENPLVARVVTVALMRAFNALLYRLNVRRRPQLQLEIVGLQSIFDYTSTCADFLKDERGRLNAFDQGRMEKTLNERLSSADSLKTVALSVYSQSRIVLADVVRGILPKSMTRFGPASAMGDLLGDLDKKEPTFYKVPCKPFILAPPPPVMQRSSGDIMQINTDETVLFVSYCLIGNDWLAATVTDHQGHLLDNCLINLRLKPDHKRVNMRYKQSTQIRDSLYRLWSYILGTLATGTKNWRLVIGRVGRIGHGEFKFWTQLLSKSYLKQVGSRMKHACRSCHMMPGTAETPGVLSACLVSLEPEAHLRIFPSSFQHDERFVKNARYRTLTTPDDCSCTHILVFPTSPELNLDHQGGSGAAELEEDDFSNLLTEEIGEEFSDLIGNGEDLISNASGPPPQSAGFRIGGNTGIPSEYADVSIENQPLATGYYVSTAPASELPDWFWSACPSAKRRNPVHLKSSLHLNTPNVQQGDDISSFGAKSSETSHHQLDSQATVDVLRYVLETYNALSWLNMDFVTGERRSCLPVHIQALMRLCNTANRLIN
Length2861
PositionMiddle
OrganismAscaris lumbricoides (Giant roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Ascaridomorpha> Ascaridoidea> Ascarididae> Ascaris.
Aromaticity0.07
Grand average of hydropathy-0.409
Instability index57.15
Isoelectric point6.09
Molecular weight313328.01
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04900
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     434.29|      74|      81|     676|     750|       1
---------------------------------------------------------------------------
  676-  704 (40.31/14.69)	.......................................................AFVL.FHRR..S.PSCA......RSP......SPPRS.PFWEERLS
  705-  786 (138.98/77.76)	SLINEPVDSERGSPDWIHESV..AHGSSLSSSRSARLELNQGGRcFAYccdvcirAFVL.FHRR..S.PSCA......RSP......SPPRS.PFWEERLS
  787-  854 (116.26/59.84)	SLINEPVDSERGSPDWIHESV..AHGSSLSSSRSARLELNQDDR.YQY................peS.PSGG......TPE......SPDYR.KVHRKRLG
  855-  892 (49.51/20.37)	SSLSKPANCK...P.............................................vYQNL..S.PSTS......RPR......SPVTGvPQASGTLG
  906-  943 (32.26/ 9.93)	SPLNVPPESGRGNDEMISKKLikVEVGDLTSIRTGCLE...............................................................
 1116- 1176 (56.95/24.77)	VHLSPPASNERVEPQTIC........SSLGSAVTNNLLARVGG........................pPSVGdymiypTPPsvdatqSQPFS.P.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.89|      23|      39|     172|     194|       2
---------------------------------------------------------------------------
  172-  194 (53.45/28.54)	GEDGQGNWSVPGIQYETRTLFFK
  212-  234 (53.45/28.54)	GEDGQGNWSVPGIQYETRTLFFK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     320.67|      28|      29|    1516|    1543|       3
---------------------------------------------------------------------------
 1413- 1442 (28.89/ 8.18)	..SASGFMgtgsGPMV..SNG.G.......GSGMMGMMM..AGT
 1446- 1464 (25.61/ 6.34)	MVHSGG......APMH..SMI.G.......GPPSM.........
 1487- 1514 (30.85/ 9.28)	LSYAPAPT....AP.....GQhH.......GGGFMGQPQygVPP
 1516- 1543 (59.68/25.45)	MMSAPGQM....GPMH..NGR.M.......GPGSMGGPP..APQ
 1547- 1571 (40.53/14.71)	MMQ.PGQA....PPMM..VG..........GPNS.GAPM.mHPQ
 1572- 1598 (30.90/ 9.30)	MQS...QQ....QPFQqlSQF.V.......NNTNFAGQQ..VPP
 1600- 1627 (36.99/12.72)	MNPQQQQQ....QMFQ..QQL.L.......YRSNMAGST..TPQ
 1629- 1654 (32.64/10.28)	SINSPG......GYMM..DSQ.A.......STPIEPPPP..FSQ
 1672- 1704 (34.58/11.37)	VYSQSPQM......MR..SGS.LmaqtnaqGGAMMLGPR..TPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.83|      27|      29|    1047|    1075|       4
---------------------------------------------------------------------------
 1019- 1054 (42.06/20.05)	SQMTSTANTQPSNTPTGSA..amqhpqllsSSA...PSCLP
 1057- 1097 (36.77/11.57)	SQGLSVPNTSSGITMPGSSgglgsdvygvdSDAqflDDCSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.48|      25|      44|    1887|    1911|       5
---------------------------------------------------------------------------
 1887- 1911 (42.83/32.71)	RDLGGIVQ...QVTMLSIQCERAAQFER
 1930- 1957 (42.65/32.53)	RELPLVFQaacEVACMEMNCRRPPHDNR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.47|      40|      44|     324|     367|       6
---------------------------------------------------------------------------
  324-  367 (65.18/41.04)	SLRAHLLPDQPRIvtmpVPASHPAFANDGGFPSMEMN....KPGVSSL
  371-  414 (64.29/31.98)	RCEPPFGAHQSAV....LPCSSSAANNMSSVNTADMHntiaKETVDKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     158.20|      48|     806|    1771|    1824|       7
---------------------------------------------------------------------------
 1771- 1824 (75.37/54.39)	ACPICSCNGNiRAKELGVyITPPEVLRQPPAQQQIIvskPtSGF...........YNNTSNPCNC
 2594- 2652 (82.84/41.61)	ACRSCHMMPG.TAETPGV.LSACLVSLEPEAHLRIF...P.SSFqhderfvknarYRTLTTPDDC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.60|      37|      37|     472|     508|       8
---------------------------------------------------------------------------
  469-  506 (55.14/35.87)	WYpSALIVVQASDDLLLRSEEGESSEEELE..NLAARVHM
  507-  546 (53.46/34.52)	TNsSNTSAMRATTPISLRKRQRKHRETELDgpNGERRNMM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     283.87|      94|     895|    1196|    1295|      10
---------------------------------------------------------------------------
 1196- 1295 (150.86/107.36)	PFMMQPFTTAtnicHTLPPQLLPNTihDVETCEN.LVAIKKEIENEEERIDK.KP.....QEKLER.LLSEKPVYG.DVKKIEI....ALSGKFAGDIFRGEPLPLEFFIGSS
 2112- 2218 (133.02/80.19)	PFAREPFKDG....MLRVPARFPST..NPGECDNfLNQVERHMGDNKTLIARlKAymqcfENEVSRvLLNSDCIFTrDTYRTLIvehqAQSGLLSSTNVAFQPGAVPVASGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.18|      16|     241|    1469|    1484|      11
---------------------------------------------------------------------------
 1469- 1484 (32.11/16.84)	MNAQMN..MAQLRTPGRP
 1709- 1726 (27.06/13.02)	MQAAVNspMSNQIYPGRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.44|      17|      17|    1379|    1395|      12
---------------------------------------------------------------------------
 1363- 1378 (21.86/ 8.60)	.TQNSTPRLPHYRLNYN
 1379- 1395 (30.86/15.52)	PTQMCSSNIPNIQASTS
 1399- 1412 (23.72/10.03)	P..ICGSQPSNV.VSAS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04900 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASSASGFMGTGSGPMVSNGGGSGMMGMMMAGTNTGMVHSGGAPMHSMIGGPPSMGMQSMNAQMNMAQLRTPGRPQSLSYAPAPTAPGQHHGGGFMGQPQYGVPPSMMSAPGQMGPMHNGRMGPGSMGGPPAPQGLGMMQPGQAPPMMVGGPNSGAPMMHPQMQSQQQPFQQLSQFVNNTNFAGQQVPPGMNPQQQQQQMFQQQLLYRSNMAGSTTPQQSINSPGGYMMDSQASTPIEPPPPFSQAISGRYSNSPSGSATPSVYSQSPQMMRSGSLMAQTNAQGGAMMLGPR
2) DCSPSTVAMMDTSSPVEPVTDSVHLSPPASNERVEPQTIC
3) EDDRSGDLLMDEPMVTVKAEPVEAGESECAAGSQMTSTANTQPSNTPTGSAAMQHPQL
4) FWEERLSSLINEPVDSERGSPDWIHESVAH
5) GAVPVASGSSEQMPPPAAPSSVCSNVQLGDTPQGPNSAGPGSVGPTSAGCSGEPLTPDNVVSGEAAA
6) LRSEEGESSEEELENLAARVHMTNSSNTSAMRATTPISLRKRQRKHRETELDGPNGERRNMMYNT
7) PSSARRRESMGSPASSGLGLLISGGNNDDDTRWNLTDGMRRK
8) SKPANCKPVYQNLSPSTSRPRSPVTGVPQA
9) SRAQMSSVASTSGVSSQSATPQHGTPQPTRVPTPCGNGGDETAPGTPKEA
10) SSSRSARLELNQDDRYQYPESPSGGTPESPDYRKVHRKRLG
1411
1094
987
698
2209
485
568
858
627
814
1701
1133
1044
727
2275
549
609
887
676
854










Molecular Recognition Features






MoRF SequenceStartStop




NANANA