<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04897

Description Uncharacterized protein
SequenceMSRRGYEMEDDEEYMKPMLPTVPEKCGPPVINLGLLIEFAVQQILHELTVLTELLPKKLDADRKISIVQFAHATRTIFIKLLAVVKWVKSSKKFESCASICYFLDQQAQYFIETADRLAQLSREELVHARLPAFQVPAAVDVLTLGAYPRLPLCIKNRFIPEGAITAREQACVLLRLNQVIQSRLSLAAAKFSPRIRNIIIKNGMVNMTVPGEFEVSLTLLGERANTKWTLLDIRILVEDYEIGFGTRLVHPLQVNTVHNVLQLRMDNSNEPLSEVYSVLHSFAQSLQLDVLCCQASRVINGQMRQYALIERYDHKEGVLIIAYWLKRTQHNRYTSQYRMKIFSDPEKEHSGLQVRHYPVGKCLPQIDDRTGRLSVSRLLSETVSVRCRERLLRVRERLECIKPRVRVYLTGKAAPTLTYPLLGADSHDDEMLVLCVNAFSGNILTLVRSLGSRQELRDLEQLLNDCAPLPAISKLLSRLRILVMVERYRKAVAPLPVRIVAESLMKVHLSNMQSMPPDRICLQFIREDSYFLIVCFVPCEVRGVEIDIYLLSNVEGKMNLVRMHPSQTLTSAPTSNFYANHGDDSPPPAKRSRWLGNTKQLTSSVATIDDRLSFMRICEELDRRGVKYRPLVAEPTVGGLMLQITDFSSAVSTASSSFLASVVRCVLRLDTRTRVIWPFEHTVVDVPLVADFYHSRYAHKPLRTKTSVLEIHSSGGVSVTSTNTADSVSQNMIDRMIAFSHMHDVVKNFAVAYYAHYHKLCCITAFTYHKLVIAYGAQRDQLMFVSWRMMKNANPKQYFYLTFGIGPNRAIANAKTLSIEPERPTQWNPHMLLKDRLQENLNRRRSLTELMQYLIETVAPLSSLHAFTKIKLQSLRAYSQMLCADSSLPVSLQASLLVVDELTIRLVYGPIELEFLLLSGSRVAVRDCARSTPTAYRLHTFCSRFVTHELRIAHEERSPGNLSWMRSPSGPSSLPPHQMGRSPASRIVASPMSHMSLSVPPAESEASPLRCIPSEHSSHSRAPILIDHNALQRMTSINECGVCPLEEYLFALSYLSRLGPALEGYRREHRGSGAHPVVQFRHLSVTPESIRVSVIGAAPPNMKHDPFIVTFHIHLDEETMTLKLKLDFEGEEIPPMMDIRIAERYFERCVARLGNELALVSFINACRLAVPGAFSAMAKIMNAQMEWTEDSPWRPSLQLTVWSHEGSNPRARLSLGIVIDQTNVSVLILLCLRATRHDPNERNADASKHLIQLIYNTQTNSVMRRGGAGEEDASGINQLLGTISEKYARLNERSLWPAVHALAHNFMHSRTVPA
Length1315
PositionTail
OrganismAscaris lumbricoides (Giant roundworm)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Spirurina> Ascaridomorpha> Ascaridoidea> Ascarididae> Ascaris.
Aromaticity0.07
Grand average of hydropathy-0.109
Instability index49.22
Isoelectric point9.01
Molecular weight148735.67
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04897
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     386.25|     124|     137|    1011|    1146|       1
---------------------------------------------------------------------------
 1011- 1146 (202.58/163.75)	RCIP...SEHS..SHSRAPILIDHNALQRMTSINECGVCPLEEylfalsylSRLGPALEGYRREHRGSgaHPVVQFrHLSVTPESIRVSV.IGAAPPNMKHDP....FIVTFH.IHLDEETMTLK.LKLDFEGEE....IPPMMDiRIAERY
 1149- 1288 (183.67/120.24)	RCVArlgNELAlvSFINACRLAVPGAFSAMAKIMNAQMEWTED........SPWRPSLQLTVWSHEGS..NPRARL.SLGIVIDQTNVSVlILLCLRATRHDPnernADASKHlIQLIYNTQTNSvMRRGGAGEEdasgINQLLG.TISEKY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.26|      37|     137|     457|     497|       2
---------------------------------------------------------------------------
  457-  497 (52.60/44.98)	LRDLEQLLNDCAplpAISKLLSRLRILVMVER....YRKAVAPlP
  596-  636 (59.66/36.54)	LGNTKQLTSSVA...TIDDRLSFMRICEELDRrgvkYRPLVAE.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.87|      39|     413|     247|     319|       3
---------------------------------------------------------------------------
  237-  294 (55.11/79.55)	LVEDYEigfgtrlvhplqvnTVHN..VLQLRMDNSNEPLSEvysvlHSFAQSLQLDVLCC
  309-  363 (59.75/37.66)	LIERYDhkegvliiaywlkrTQHNryTSQYRMKIFSDPEKE.....HSGLQVRHYPVGKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.35|      10|      20|     752|     761|       4
---------------------------------------------------------------------------
  752-  761 (19.46/11.36)	VAYYAHYHKL
  774-  783 (17.89/ 9.88)	IAYGAQRDQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     215.12|      69|     786|     144|     217|       6
---------------------------------------------------------------------------
  144-  217 (106.48/75.75)	TLGAYpRL.PLCikNRFIP.EGAITAREQACVLLRLNQVIQSRLSLAAAKF..SPRIRniIIKNGMVNMTV...PGEFEVS
  933- 1008 (108.64/62.15)	TPTAY.RLhTFC..SRFVThELRIAHEERSPGNLSWMRSPSGPSSLPPHQMgrSPASR..IVASPMSHMSLsvpPAESEAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.36|      17|      18|     890|     906|       9
---------------------------------------------------------------------------
  890-  906 (26.34/14.83)	PVSLQASLLVVDELTIR
  911-  927 (27.02/15.40)	PIELEFLLLSGSRVAVR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04897 with Med14 domain of Kingdom Metazoa
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