<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04886

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAAELGQQTVELSTLVTRAAHDSYASLKELVDKCRSSELSDTDKKISILKFLSKTQQRMIRLNVLSKWCQQVPLIQHCQQLASTVSNHDMCFTQAADSLFFMHEGLQQARAPVYDVPSAIDILLTGSYQRLPKCVEDVGTQYALTEDQQKPALKKLDTLVRSKLLQVSIPKEFSDINVSDGTALLRVDGEFKVLITLGYRGHLSLWRILHLELLVGEKNKPVKLEEMRRHVLGDDLERRMAAADNPFSVMYSVLHELCVALVMDTVIRQVQVLRQGRWKDAIRFELISEGHGASSSSVQNPDSESDSSALRTPGLKIVYWLDFDKNANAPESGTCPFIKIEPGSDLQIKCLHSSFVIDPLTGKEAEFVLDQSCIDVERLLLRAICCNRYTRLLEIKRELGKNVQVCRTADDVVLQSRMGEPDIEYKQKDEKCCSKDSEGHEVLCVRAYGSSFFTLGINIRNGRFLLQSSQNIVVSSALIECEEALNQGSMTAAEVFISLRSKSILHLFASIGRVLGLEVYEHGFNIVKIPKDVSNGSAMLLMGFPDCGSSYFLLMQLDKDFKPLFKLLETQPDPSGTDNLSGGDLNQVLRIKKIDIGQMQVHEDEMNLSLVDWGKLRSALPNAIGPNQTSGHEFFSDIRLENSIQISRGHPSGFSSLVDEVFGLEKGSSAAPLSVQNISSTGNTSLPSQYGSVPMNIHSLKAGSPSPKWEGGMQIAQVNNVTKASGATSLYSGSLFSSGSVKGPVQSSSVGSIPTGQVRSTAGKKLSASKSEQDLTSPKSPHSVDISSSAAIDEEQLRVLNDTSNEGLSGSRSSRLLSPPRPTGSRMPNSRPNGSQVDSFKAAGSCATTPVSQTLESTVSYSTGEDVTSKNDKKSRKRTASDMLALIPTLQGVENNPGICKRRKLSDSSGCQLSLAQGAMSSEMIPKTEGYSYGSLIAEVNKGTVPSSIYIVALLHVVRHCSLCIKHARLTSQMDALDISYVEEVGLRSGSSNIWFRLPLARGDSWQHICLRLGRPGCMYWDVKINDQHFRDLWELQKGSNNTPWGSGVRIANTSDIDSHIHYDPDGVVLSYQSVEVDSIKKLVADIQRLANARTFALGMRKLLGVRAEEKSDDLVTSTDSKTPSSKVSSDTADKLSEQMRRAFRIEAVGLMSLWFSFGSSVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVSSLLDCIRLTAGPLHALAAATRPARAGPVPGVAAALSSIPKQSGGYISSQGLLLGNSTTNVGQPTSGPGANTVMPTASGLTNQTLSMLAAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIMYRKQFAVDMRCFAGDQVWLQPATPPKEGRLSGGSLPCPQFRPFIMEHVAQELNGLDPSFTGQQAGGLSNSNNPNPGSGSQMMAANGNRINLPISAAMSRTGNQVASLNRVGNALAGSSNLALMTSPVSLRRPPGAVVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKENEGALLNLDPEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHQQQQQQQQNSNPAPEELSQSEISEICDYFSRRVASEPYDASRVASFITMLTLPVSVLREFLKLIAWKKGLSQTQVGDVVSAQKPRIELCLENHSGLNADENSESSSAFRSNIHYARLHNSVDFALTVVLDSSHVPHVNAAGGAAWLPYCVSVRLRYSFGESSNVSFVAMNGSHGGRACWLRVDDWEKCKQRVARAVEVNGSSAADISQGRLKLVADSVQRNLHICIQGLRDGNGVTASSGAT
Length1811
PositionTail
OrganismPhaseolus angularis (Azuki bean) (Vigna angularis)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Vigna.
Aromaticity0.06
Grand average of hydropathy-0.182
Instability index43.25
Isoelectric point7.80
Molecular weight196741.62
Publications
PubMed=26460024

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04886
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1188.71|     338|     353|     850|    1199|       1
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  656-  844 (189.98/94.25)	..........................................................................................................................................SLV..DEVfGLEKGSSAA....PL....SVQNISStgNTSLPS.Q.YGSVPMN..IHSLKagspsPKWEggMQ...iaqvNNVTKASG.......ATSLYSGSLFSSGSVKGPVQSSSVGSIP..TGQVRSTAGKKLSAS.....KSEQDLT......SPKSPHSVDISSSAAIDEEQLRVLNDTSNE.................GLS.GSRSSRLLS......PPRPTGSRM...PNS.RPNGSQVDSFkAAG
  850- 1199 (534.09/317.84)	PVSQTLEsTVSYSTGEdvTSKNDKKSRKRTASDMLALIPTLQGVENNPG..ICKRRKLSDSSGCQLS.LAQGAMSSEMIPKTEGYSYG..SLIAEVNK...GTVPSSIYIVALLHVVRHcSLCIKhARLTSQMdALDISYV..EEV.GLRSGSSNIWFRLPLaRGDSWQHICL..RLGRPGCM.YWDVKIN..DQHFR.....DLWE..LQKGS....NNTPWGSGVRI..ANTSDIDSHIHYDPDGVVLSYQSVEVDSIKKlVADIQRLANARTFAL.....GMRKLLG......VRAEEKSDDLVTSTDSKTPSSKVSSDTADKLSEQMRRAFRIEAVglmSLW.FSFGSSVLARFVVEWESGKEGCTMHVSPDQlWPHTKFLEDF.ING
 1201- 1546 (464.64/245.08)	EVSSLLD.CIRLTAGP..LHALAAATRPARAGPVPGVAAALSSIPKQSGgyISSQGLLLGNSTTNVGqPTSGPGANTVMPTASGLTNQtlSMLAAAGRggpGIVPSSLLPIDVSVVLRG.PYWIR.IMYRKQF.AVDMRCFagDQV.WLQPATPPKEGRL...SGGSLP..CP..QF.RPFIMeHVAQELNglDPSFT.....GQQAggLSNSN....NPNP.GSGSQMmaANGNRINL.....PISAAMSRTGNQVASLNR.VGNA..LAGSSNLALmtspvSLRRPPGavvpahVRGELNTAIIGLGDDGGYGGGWVPL.VA..LKKVLRGILKYLGV....LWlFAQLPDLLKEILGSILKENEGALLNLDPEQ..PALRF...F.VGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.44|      53|    1366|     252|     311|       2
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  252-  311 (77.61/92.20)	SVLHELCVALVMDTVIRQVQVlrqGRWKDA..IRFELISEGHGASSSsvqNPDSESdSSALR
 1624- 1678 (86.84/74.70)	SVLREFLKLIAWKKGLSQTQV...GDVVSAqkPRIELCLENHSGLNA...DENSES.SSAFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.30|      44|    1581|     102|     146|       3
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  102-  146 (72.55/51.15)	MHEGLQQARAPVYDVPSAIDILLTGSYQRLPKCVeDVGTQYALTE
 1686- 1729 (77.75/50.53)	LHNSVDFALTVVLDSSHVPHVNAAGGAAWLPYCV.SVRLRYSFGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.14|      33|      47|     566|     598|       5
---------------------------------------------------------------------------
  566-  598 (55.57/36.83)	KLLETQPDPSGTDNLSGGDLNQVLRIK.KIDIGQ
  615-  648 (51.57/33.58)	KLRSALPNAIGPNQTSGHEFFSDIRLEnSIQISR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04886 with Med14 domain of Kingdom Viridiplantae
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