<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04832

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMIQHQIVQSPARLGLANPNSPSIPNPTPPKLPPTQTQQPQDRNSSTPSSALLSLLPPLPRAQALLLQMASLTSKIFEVSPNRSLWVTAFRGSLPTFLSSNSSTPLDSSPSTVKEIISLFTVLQTQIFEAVAELQEILDLQDAKQKMDREIRSQDSMLLAFSNKLKDAECCLDILVDDYSDYRRSKRSKSGDDDSMTSSTVSSQLKLSDILSYAHKISYTTFAPPEFGAGQAPLRGALPPAPQEEQMRASQLYNFADLDVGLPKEVESKEKIVEAIVEPPSQMDTNAVPNLSAFQGMLPPVPPGWKPGMPVQLPIDLPLPPPGWKPGDPVPLPPMDSLQIPRFAEQQMQPHIPQPKQPEVIQVQPVNLDLGGSDTSDYSSDDASSYDED
Length388
PositionMiddle
OrganismPhaseolus angularis (Azuki bean) (Vigna angularis)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Vigna.
Aromaticity0.05
Grand average of hydropathy-0.421
Instability index70.34
Isoelectric point4.64
Molecular weight42410.53
Publications
PubMed=26460024

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04832
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.36|      18|      18|     301|     318|       1
---------------------------------------------------------------------------
  301-  318 (40.43/16.84)	PPGWKPGMPVQL.P.ID.LP............L
  320-  351 (22.07/ 6.41)	PPGWKPGDPVPL.PpMDsLQiprfaeqqmqphI
  352-  369 (24.87/ 8.00)	PQPKQPEV.IQVqP.VN.LD............L
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.25|      31|     203|      15|      94|       2
---------------------------------------------------------------------------
   31-   77 (38.69/76.64)	LPPTQTQQPQDrnsSTPSSA..LLSLLpplpraqalllqmASLTSKIFE
   96-  128 (47.56/ 6.80)	FLSSNSSTPLD...SSPSTVkeIISLF.............TVLQTQIFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.12|      16|     193|     177|     193|       4
---------------------------------------------------------------------------
  177-  193 (26.18/18.60)	DYSDYrRSKRSKSGDDD
  373-  388 (29.94/16.69)	DTSDY.SSDDASSYDED
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04832 with Med4 domain of Kingdom Viridiplantae
Unable to open file!