<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04797

Description Uncharacterized protein
SequenceMSERLSSERVRVFSRSLLNSTEIPSKRDYKREQQKMASYPSQEQRPLKKPRLGPPDVYPQDPKQKEDELSTLNVKHGFNNNCTITDEYGSACRSINQDKVALFSKVGTCFSSMMTKKTELNTFQDTGKKKQQLNIKDNFRPVTARTRNAMEAWFKDLAGSKPLSLLVKKVPIFNKKEEIFSTLCDFSIPMIKAAWFVKMTAAHNVALQENKTKKRQTVDQCLDSYTKLQSDLAEFLQLDAFPNANHSESVEGLLDRHEFLTWLLEHMEKIRPNDDSVLKLLLGQIVYYLDEVSMSVYLSRKLSHFCAKRIAQFTSEYGICSPRTDSPMMTNGNGTGNNNPLSNPLSVLFTEYVTCLEHRSLILMLCATLQIITIRCPAALVWNNLGDGKTCNFLCGSPLDLLGCGTSSLPMPPNPDNQLIRAKIRAVEQQIRLRGHAAEVRWSSDKCQQSTKGFTISKVLNVLDILDCHYFDKVDANNSMNSLYNKIFCHNENKEGNEPLVSDDPIIKLLIDWAVTIQRTGNYRAVVVAKLLERRQNDMRNEKFADSEMMDDKDSIASDVMMSSGYPAYQQLLMEFLDEDAPVLDDSGLEENRDAFSNLIQLFCELIRFDVFSHDAYMCTLISRGDLAASPSVAMPSADSVDLSSVKSLSESIKHEHQDDIKMDLDIHTMESDLGSLFGSVKEEQKTSPEAPASVKSVKSERDQPIMSVGESQSAPPQPPPPKGPSRHMLFATHFPIPQNESYAHECNQRFVVLYGVGKARDNARHIIKKVTKEILRLFNKKNCIDISSGDPTKVKKKKEKEKDKDSDSSSNLESTFNKFQRLSYYDMHAVTSSCVSSVLEQLSSFAAGNSCYLPVVDNISYLFDLMDYSLNISGLLDFALQLLKELSQVEVQLMLKASSLATNYVSSLCLCIIGIFSKYCSYMLVCQDLACAAFEGLNAIIKHINNPSDCTSAERCVQAYLFDLYTSASYLKAKYLDSFSATFSKMKQTHDTNITPSVLNLLWDPNFMMDYFNDVKSIPDAMLVKQLNENPGYRYNFVCNAVLNICNSQVTDRLNEISILCAEFTAKCNALRSEWLGALKALCCSSNHSCGFIDILTQIDVGDLSIHDSLAVFTAILLARHCFTLQNFIARVALPSLMSACPSMLGAQDAESGARLTCHLLLRLFKTTNHPGFHNLNCRNGCGVKASCDRHLLAATHDSLTVEPVLGVLKGMLYLRDSCNDESKAKAGVCNNSGSIPSNSAGQKTGDIIGNILGNLNDDDMELDLVLGGSSKSNKRIESAGLSDFAKHSLKEMCCQKWVREKILKDPQALFSEDRLMDPELSNKQALQLLQMICYPNGIPNQAEGTEPDNKQVINRILQETNAILDCIAKGTLDLFHQQTEFLSNPNSPRQQLPTQQQQQQLQNAKPESEKDSVWLVAPLISKLPSTVQGRLLKLAGQVLESSSNFLSKTKYDKEKNQRNKSLLGHQPFLSLILTCLKGQDEQRECLLSSLHFQLEKFISNVKEVLDRSPDETKIRQNLNEALQLRLSLVGGMFDTIQRNNATTSDWAVLLVQLISHGVVDMQTNYELFTTVIDMLNVLIHGTLLGDSNEKGDDNKRTYQNLIKKLKRELGDKNNTCIDKVRQLLPLPKKLYEVITCEPHGTLVDTKGYKIAGFDSIGRKQGLQVASKVKITPWEIIEGTKNPAPLSWTYFGAVKMEKKMLKYDDQYRLLCYHTHVMRQPTSCYLEPPPLPAEELEPPAEKLQEEKPKEPAENSKDDLSKKKHQRRRRNPRTNSSYMQHQPIPHRVNYGQDIYQPGPPPNWYGPPQQQTPYYSTQHLPPGGPAAARFASPQYNSPKQELRTMLRARQPATQGYIQHNTQQPTFPSIQMMQSKQRSQIIRQSLRAQAQHQQNLQRGHPVGAPPDTQPHYNPQLAGNPQATLHHMTQTQGMNPSYHSYNGIPIQQPAVMDPVSSGMLSQNFGQSYPNAQNPAMMQGIQPPANQSQRQGPGFMAQQPQQNPQAAFNRGSRLPPQMTPSSLQRHTNSMGSMSNYSQLGPTGPPQQSHAYMQGMPPPAQQQQQQQQQQQQQQLLQQQQQQQQQQHQQQQQQQQQQQPAPQPPQRMLVMPNSQIQPTTQQQLVAQLHRQLGPPGPQYNNYQPSQY
Length2140
PositionKinase
OrganismOctopus bimaculoides (California two-spotted octopus)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Mollusca> Cephalopoda> Coleoidea> Octopodiformes> Octopoda> Incirrata> Octopodidae> Octopus.
Aromaticity0.07
Grand average of hydropathy-0.536
Instability index52.58
Isoelectric point8.04
Molecular weight240722.24
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04797
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.37|      14|      16|    2055|    2068|       1
---------------------------------------------------------------------------
 1986- 1999 (23.46/ 7.42)	QGPGFMAQQPQQNP
 2082- 2095 (24.90/ 8.35)	QQQQQQQQQQQPAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      81.98|      18|      18|    2048|    2065|       2
---------------------------------------------------------------------------
 2048- 2064 (31.66/10.72)	......QGMPPPAQQQQQQQQQQ
 2065- 2080 (24.39/ 6.60)	Q....qQQL..L.QQQQQQQQQQ
 2117- 2139 (25.93/ 7.47)	LvaqlhRQLGPPGPQYNNYQPSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.89|      14|      18|    1720|    1737|       3
---------------------------------------------------------------------------
 1718- 1732 (23.32/11.29)	MRQPTScYL..EPPPLP
 1736- 1751 (16.57/ 8.20)	LEPPAE.KLqeEKPKEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.92|      16|      19|    1047|    1062|       4
---------------------------------------------------------------------------
 1047- 1062 (28.60/20.50)	CNSQVTDRLNEISILC
 1069- 1084 (29.32/21.23)	CNALRSEWLGALKALC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     108.74|      21|      22|    1929|    1949|       5
---------------------------------------------------------------------------
 1848- 1871 (21.75/ 6.04)	...QPAT.QGY.....IQHNTQQPTfpsiqMMQ
 1929- 1949 (38.48/16.64)	GM.NPSY.HSY.....NGIPIQQPA.....VMD
 1954- 1974 (26.21/ 8.86)	GMlSQNFgQSY.....P..NAQNPA.....MMQ
 2024- 2047 (22.30/ 6.39)	SM.G.SM.SNYsqlgpTGPPQQSHA.....YM.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     107.49|      21|      74|    1816|    1837|       6
---------------------------------------------------------------------------
 1786- 1799 (23.08/ 9.01)	RVNY.GQDIYQ..........P.GPP
 1800- 1824 (33.29/21.56)	PNWY.GPPQQQtPYystQHLPPGGPA
 1884- 1899 (22.60/ 8.62)	..R..AQAQH...Q...QNLQRGHPV
 1900- 1918 (28.52/13.31)	GAPPdTQPHYN.PQ.....L.AGNPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     769.76|     220|     223|     197|     419|       7
---------------------------------------------------------------------------
   67-  230 (185.18/129.06)	.............................................................DELS.TLNVKHGFNNNCT.....ITDEYGsACrSINQDKVALFSKVGTCFSSMMTK..K..........TELNTFQDtgKKKQQLNIKDNFRPVTARTRNAMeAWfKDL..AGSKPLSLLVKKvPIfnkkEEIFSTLCDFSIPMIKAAWFV..KMTA.AHNVALQENKTKKRQTVDQCLDSYTKLQS
  231-  456 (357.15/271.12)	DLAEFLQLDAFPNANHSESVEGLLDRhEFLTWllEHMEKIRP..NDDSVLKLLLGQIVYYLDEVSMSVYLSRKLSHFCAKRIAQFTSEYG.IC.SPRTDSPMMTNGNGTGNNNPLSN..P.....LSVLFTEYVTCLE..HRSLILMLCATLQIITIRCPAAL.VW.NNL..GDGKTCNFLCGS.PL....DLLGCGTSSLPMPPNPDNQLIraKIRAvEQQIRLRGHAAEVRWSSDKCQQSTKGFTI
  461-  636 (227.43/161.91)	NVLDILDCHYFDKVDANNSMNSLYNK.IFCHN..ENKEGNEPlvSDDPIIKLLIDWAVTIQRTGNYRAVVVAKL...LERRQNDMRNE.......KFADSEMMDDKDSIASDVMMSSgyPayqqlLMEFLDEDAPVLD..DSGLEENRDAFSNLIQLFC..EL.IR.FDVfsHDAYMCTLI..S.RG....DL..AASPSVAMP............................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.66|      22|      22|    1586|    1607|       8
---------------------------------------------------------------------------
 1586- 1607 (38.85/20.70)	LGDSNEKGDDNKRTYQNLIKKL
 1611- 1632 (39.81/21.39)	LGDKNNTCIDKVRQLLPLPKKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.77|      15|      18|     822|     839|       9
---------------------------------------------------------------------------
  813-  835 (15.72/16.91)	LESTfnkfqRLSYYdmhAVTSSC
  836-  852 (21.05/10.92)	VSSV...leQLSSF...AAGNSC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.37|      14|      18|    1378|    1391|      10
---------------------------------------------------------------------------
 1378- 1391 (26.75/14.36)	HQQTEFLSN..PNSPR
 1397- 1412 (20.62/ 9.14)	QQQQQQLQNakPESEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.62|      26|      29|     667|     692|      11
---------------------------------------------------------------------------
  644-  664 (25.19/11.34)	.....SSVKSLSESIKHEHQDDIKMD
  667-  692 (42.62/24.66)	IHTMESDLGSLFGSVKEEQKTSPEAP
  695-  720 (41.80/24.04)	VKSVKSERDQPIMSVGESQSAPPQPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.12|      29|      29|    1468|    1496|      12
---------------------------------------------------------------------------
 1468- 1496 (50.33/33.13)	QPFLSLILTCL.KGQDEQ..RECLLSSLHFQL
 1497- 1528 (35.79/21.18)	EKFISNVKEVLdRSPDETkiRQNLNEALQLRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.64|      23|      28|    1320|    1347|      13
---------------------------------------------------------------------------
 1320- 1347 (33.23/42.71)	PElsNKQAL.QLLQmicYPNGIPN.QAEGT
 1349- 1373 (31.41/20.98)	PD..NKQVInRILQ...ETNAILDcIAKGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.52|      17|      18|    1645|    1662|      14
---------------------------------------------------------------------------
 1645- 1662 (25.59/19.97)	VDTKgYKIAGFDSI.GRKQ
 1666- 1683 (25.93/14.70)	VASK.VKITPWEIIeGTKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.41|      12|      18|    1754|    1765|      15
---------------------------------------------------------------------------
 1754- 1765 (20.35/16.46)	NSKDDLSKKKHQ
 1770- 1781 (23.05/20.17)	NPRTNSSYMQHQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.52|      22|      27|     988|    1014|      17
---------------------------------------------------------------------------
  988- 1012 (35.63/28.82)	KQTHDTNItpsVLNLLWDPNFMMDY
 1017- 1038 (38.89/16.83)	KSIPDAML...VKQLNENPGYRYNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.16|      22|      28|     895|     916|      19
---------------------------------------------------------------------------
  892-  913 (35.37/25.97)	VQL.......MLKASSLATNYVSSLCLCI
  914-  942 (27.79/18.44)	IGIfskycsyMLVCQDLACAAFEGLNAII
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      28.26|      10|     208|     734|     755|      21
---------------------------------------------------------------------------
  722-  731 (20.50/12.16)	PKGPS.......RH.MLF
  738-  755 ( 7.76/16.32)	PQNESyahecnqRFvVLY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04797 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FGSVKEEQKTSPEAPASVKSVKSERDQPIMSVGESQSAPPQPPPPKGPSRHMLFATHF
2) SCYLEPPPLPAEELEPPAEKLQEEKPKEPAENSKDDLSKKKHQRRRRNPRTNSSYMQHQPIPHRVNYGQDIYQPGPPPNWYGPPQQQTPYYSTQHLPPGGPAAARFASPQYNSPKQELRTMLRARQPATQGYIQHNTQQPTFPSIQMMQSKQRSQIIRQSLRAQAQHQQNLQRGHPVGAPPDTQPHYNPQLAGNPQATLHHMTQTQGMNPSYHSYNGIPIQQPAVMDPVSSGMLSQNFGQSYPNAQNPAMMQGIQPPANQSQRQGPGFMAQQPQQNPQAAFNRGSRLPPQMTPSSLQRHTNSMGSMSNYSQLGPTGPPQQSHAYMQGMPPPAQQQQQQQQQQQQQQLLQQQQQQQQQQHQQQQQQQQQQQPAPQPPQRMLVMPNSQIQPTTQQQLVAQLHRQLGPPGPQYNNYQPSQY
3) TEIPSKRDYKREQQKMASYPSQEQRPLKKPRLGPPDVYPQDPKQKEDELSTL
678
1723
21
735
2140
72










Molecular Recognition Features






MoRF SequenceStartStop




1) KRDYK
2) QRMLVMP
26
2099
30
2105