<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04782

Description Mediator of RNA polymerase II transcription subunit 13 (Fragment)
SequenceDWSCVFKPPKLARFVGSTKYAPVELPSATEAVLTCHIPEYKPSWQYQPHAPSHYLNLPSIENLPSLSKMHAGVESSPATFTVGSVSQRTPMSYEQSPMSNASSSYVNKTLSSVDNQVTNHQFTEVHSLLVNVILADSSLNIFKDHNFDSCNICVCTMRVKDDEDNLDMNRCTCGFSAIMNRMYGHNSGLFYEDEVDITGIRDDRYDQNTNKRLAVIDYQKAGLNKDSTSTATVTAPEDVPQVILEWLLTQFCAPFPSSIAQRMFNKLIMNAATSLVDNVVNVISMQDSNEAAFTALQQGCLAADNCSPSKLDDPQIKSSCLHRWPYLQGANRIPLNSQDVLRLLKSLQPLLSDAIQKKRTMRLWEHTYKLSGPLSWKDFHQLAGRGTEENSEPQPIPSFLVGYDKDWLSVSPYALPYWDKLLLEPYGKPRDIAYVVVCPDNEYIVKNARFFFKELSTIYELCRLGRHSPITKVLRDGILKVGHSAAQKYADEPIEDWFNYIGESPVAAKLRLYARVCKHQLGPHLAQQTLDKSLFEVSCSKSNHSTPRSSDMSQAPATPEHQTSGSSTSNVTSSTAPNQPLSSQSQQQQQQQQQQQQQQQQQQQSTTTSATTNSCNTNSSSSSNNNTTTTTVTGHIGSSNPDDMNKDGGADSNSSQQQRDGGIHEQQQESEDSSTECPALVIYIVDPFTYCQEWDHLNRLGTIGLLHCYQEIVRNLPEHMQSHVSLQIIPSEAVIDQKECGSQYQMLKSLAFSVFTTCRWNLAHNVLGRSLTGFGPAADAELFLKQKEVEKAGQMRLYCPPFILAPVKDKQSTLAESCGEKLEKSTIVFCGYCLSEDQRWLLAACTDERGEMQETCIINIEIPNRNRRKKASARKAGLQKLWTFIVGIVSMTTLPCRLVIGRFGRLGHGELKGWAELLGKKNLMKASQQMRDMCTQCSIMSSSETPCILSACLVSMEPQSSFRIIFDSVKVEEKMSSNCPLQTPRDASCTHILVFPTSATAQASNHSLHRGEHSMDPTYHLGDLNTDALFPSAIEDGIGDDIGCEMDDLLSIFINPMNDDKNSASGSLIHGDEGCQSPSKMGVPSAGAVNTSNDLQEEGGTLLQQPLAMGYYVSTASTGPLPKWFWSACPEAENMCPNILKAALHTHCSSKQDDPLPLQSTHSRNIHPLDSNLTCDVLRFVLENYNALSWLTMDPVKNDRQSCLPVHFVMLMQMYHAVNAFV
Length1222
PositionMiddle
OrganismOctopus bimaculoides (California two-spotted octopus)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Mollusca> Cephalopoda> Coleoidea> Octopodiformes> Octopoda> Incirrata> Octopodidae> Octopus.
Aromaticity0.07
Grand average of hydropathy-0.411
Instability index60.23
Isoelectric point5.73
Molecular weight135786.69
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04782
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.01|      49|      78|     207|     256|       1
---------------------------------------------------------------------------
  207-  256 (79.05/54.67)	QNTNKrLAVIDYQKAGLNKDSTSTATVTAPEDVPQVILEWLLTQFCAPFP
  286-  334 (87.96/56.61)	QDSNE.AAFTALQQGCLAADNCSPSKLDDPQIKSSCLHRWPYLQGANRIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     210.52|      70|     132|     720|     799|       4
---------------------------------------------------------------------------
  720-  799 (106.82/116.21)	MQSHVSLQI.IPSEAvIDQKECGSQYQMLKSLAFSV....FTT..CRwnLahnVLGRsltgFGPAADAEL.....FLKQKEVEKAG.QMRLYC
  852-  934 (103.70/79.37)	MQETCIINIeIPNRN.RRKKASARKAGLQKLWTFIVgivsMTTlpCR..L...VIGR....FGRLGHGELkgwaeLLGKKNLMKASqQMRDMC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     358.15|      92|     435|     614|     708|       5
---------------------------------------------------------------------------
  564-  610 (55.35/28.48)	......SGSSTSN.....VT....SSTAP..N.Q..PLSSQSQQQQQQQQQQQQQQQQQQ...QSTTTSA...............................
  614-  708 (160.22/108.86)	SCNTNSSSSSNNNTTTTTVTGHIGSSNPDDMN.KDGGADSNSSQQQRDGGIHEQQQESED...SSTECPALVIYIvdpFTYCQEWDHL..NRLGTIGLLHC
 1051- 1148 (142.57/89.00)	SIFINPMNDDKNSASGSLIHGDEGCQSPSKMGvPSAGAVNTSNDLQEEGGTLLQQPLAMGyyvSTASTGPLPKWF...WSACPEAENMcpNILKAALHTHC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.22|      12|      16|     143|     155|       7
---------------------------------------------------------------------------
  143-  155 (23.08/15.38)	KD..HNFDsCNICVC
  160-  173 (21.14/ 9.39)	KDdeDNLD.MNRCTC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.31|      32|     803|     335|     366|       8
---------------------------------------------------------------------------
  335-  366 (55.41/33.73)	LNSQ...DVLRLL....KSLQPLLSDAIQKKRTMRLWEH
 1169- 1207 (47.90/28.21)	LDSNltcDVLRFVlenyNALSWLTMDPVKNDRQSCLPVH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.68|      39|     884|      86|     128|      11
---------------------------------------------------------------------------
   86-  128 (57.97/54.20)	SQRTPMsyeQSPmSNASSSYVNKTLSSVDNQVTNHQFTE.VHSL
  976- 1015 (66.70/46.72)	SSNCPL...QTP.RDASCTHILVFPTSATAQASNHSLHRgEHSM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04782 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EVSCSKSNHSTPRSSDMSQAPATPEHQTSGSSTSNVTSSTAPNQPLSSQSQQQQQQQQQQQQQQQQQQQSTTTSATTNSCNTNSSSSSNNNTTTTTVTGHIGSSNPDDMNKDGGADSNSSQQQRDGGIHEQQQESED
536
672










Molecular Recognition Features






MoRF SequenceStartStop




NANANA