<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04778
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MQREEKQLEAALDTITQRISDLKNCIHSFLMKIEHEYASMSWPNALDNFALLSGQLNSLTRLLKSEKIPPLKNYVLLPLALSPDKDPELEKLTEGRLMIFNHEVVPVYLRTKPEPEVEEKFNELTCRLGPSSHDTTQGKGIKNENMLVEDATVTRKQLNSLNKITSNIIDIINSAREEWESEANQKSAQPQTSSMADTNTLIQAITVGKGLKQPTPRRSENSHQNNNINTQPQTQKPPASANISKAPSTIKTNIKAASSHPYQRS |
Length | 265 |
Position | Head |
Organism | Octopus bimaculoides (California two-spotted octopus) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Spiralia> Lophotrochozoa> Mollusca> Cephalopoda>
Coleoidea> Octopodiformes> Octopoda> Incirrata> Octopodidae> Octopus.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.714 |
Instability index | 41.51 |
Isoelectric point | 7.77 |
Molecular weight | 29734.31 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP04778
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 147.34| 48| 69| 89| 142| 1
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89- 142 (77.69/72.71) LEKLTEGRLMIFNHEvvpvylRTKPEPEVEEKFNE.LTCRLGPSS...HDTTQGKGIK
161- 212 (69.64/51.02) LNKITSNIIDIINSA......REEWESEANQKSAQpQTSSMADTNtliQAITVGKGLK
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