<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04776

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSPIDSQLPMPTGPSQGGGTGGGSIALNTLIDYIIQRTYAEMSVLSELLPRKSDMERKIEIVQFSQRTRQLFVRLLALVKWANSASKVDKCGEICNFLEQQSLLFVETADAMARMARETLVNARLPNFPLPYAVDVLTTGTYPRLPTCIRDKIVPVDPITVTEKRLTLQRLSQVIEYRLVCSELPPQMRRLKIENGRVKFLVEHEFEVTLTLMGDSPTIPWRLLDIAILVEDHQTGDGKSLVHSLQVNYIHRLVQSRLLDNEKPLHDLYRMLHSFCLSLQLEVLHSQIQRLVRERLGDSVRVEEYTPGKCLVVSYWRDQIKKEKDSSVYKLSVHVSEEDEGKPLQISHIPLMTVEEARKVGLSIRSEHLSIEKLIIQTIEVRTHAKLKEFAKDLQKYVDGPCEIKDVPAVLHVPVLNPFTSAEVLRVAIDIQRGTFLTSVPCSNHPVIQEIEENLNGERRHLDKQIAKLRSELALLRCEKSVQQLPASSHRQLPFINFAGHALESLSKHKLYVRVPKQTSYAVVVEVEDVPPKSFVYKYYLLEMATASTENTDNTLVEDNGAVKPFLKAKHLTPINIFSLTHGPYATVFSEGDELELDSLSRKRKLLLGDQEGPPAKMRKESPYFVAPLAFLLAHCEEKLPFVSLTEELTRRNIPHQGIQVDGEGSCMTLTIMDLPNCKGCTPETMDELRKNLLSSKFRIQVRPTRNWIVEFVFTNCPIKTTSPKEQGPIQRVYFSFDLNTDQASKTVQDLLDEWTLVANLYQAVYNFSHFFNDSRTGLQKLIEVRSYNYRKLTIVYGVTQTSLVNIAWRIDTKSFHLTLGTCGQNASTINPHVLVITQLQEELNCANSTDAVANLVQLLNDTWSPLTSINKLSTSPLLGGSTHPKQSMLSFTIIPQSTTHVRITFRNVSCVDVHFRSGKMVAVRDGAISLFDTSKVIDGFTPTPGLKAFLNMFVDETVTGSHPRRRSTTEEDHPLSPIGMDSVEIFLPQNPSVGSPASRPRQDGNLRFQNPMTPPSNPHTPASPSTSRISSVSFLFYFSYVLS
Length1044
PositionTail
OrganismOctopus bimaculoides (California two-spotted octopus)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Mollusca> Cephalopoda> Coleoidea> Octopodiformes> Octopoda> Incirrata> Octopodidae> Octopus.
Aromaticity0.07
Grand average of hydropathy-0.225
Instability index45.84
Isoelectric point7.60
Molecular weight117743.95
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04776
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.28|      17|      31|     299|     315|       1
---------------------------------------------------------------------------
  299-  315 (31.42/21.83)	SVRVEEYTPGKCLVVSY
  332-  348 (30.86/21.29)	SVHVSEEDEGKPLQISH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.55|      18|      39|     243|     260|       2
---------------------------------------------------------------------------
  243-  260 (34.50/21.57)	H....SLQVNYIH....RLVQSRLLD
  273-  298 (22.05/11.22)	HsfclSLQLEVLHsqiqRLVRERLGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.10|      29|      30|      36|      64|       3
---------------------------------------------------------------------------
   36-   64 (48.01/37.25)	QRT...YAEMSVLSELLPRKSDMERKIEIVQF
   66-   97 (45.10/34.50)	QRTrqlFVRLLALVKWANSASKVDKCGEICNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.44|      37|      42|     612|     653|       4
---------------------------------------------------------------------------
  614-  653 (55.06/53.14)	PPAKMRKESPYFVAPLAFL.LAHCEEKLPfvSLTEELtRRN
  655-  692 (64.38/41.39)	PHQGIQVDGEGSCMTLTIMdLPNCKGCTP..ETMDEL.RKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.85|      17|      42|     163|     179|       5
---------------------------------------------------------------------------
  163-  179 (26.55/15.19)	EKRLTLQ..RLSQVIEYRL
  188-  206 (17.97/ 7.78)	MRRLKIEngRVKFLVEHEF
  207-  223 (27.33/15.87)	EVTLTLM..GDSPTIPWRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.78|      45|      85|     735|     779|       6
---------------------------------------------------------------------------
  735-  779 (79.45/64.35)	FSFDLNT.DQASKTVQ......DLLDEWTLVANLYQAVYNFSHFFNDSRTGL
  816-  867 (67.33/53.25)	FHLTLGTcGQNASTINphvlviTQLQEELNCANSTDAVANLVQLLNDTWSPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.96|       9|      30|     407|     416|       7
---------------------------------------------------------------------------
  407-  416 (12.60/ 9.65)	VPAVLHvPVL
  440-  448 (19.36/10.43)	VPCSNH.PVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.51|      32|     819|     125|     159|       9
---------------------------------------------------------------------------
  125-  159 (52.63/44.75)	LPNFpLPYAVDVLTTGTYP.RLPTCIRDKivPVDPI
  947-  979 (54.88/34.89)	LKAF.LNMFVDETVTGSHPrRRSTTEEDH..PLSPI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04776 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QNPSVGSPASRPRQDGNLRFQNPMTPPSNPHTPASPS
990
1026










Molecular Recognition Features






MoRF SequenceStartStop




1) LFYFSYVL
1036
1043