<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04776

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSPIDSQLPMPTGPSQGGGTGGGSIALNTLIDYIIQRTYAEMSVLSELLPRKSDMERKIEIVQFSQRTRQLFVRLLALVKWANSASKVDKCGEICNFLEQQSLLFVETADAMARMARETLVNARLPNFPLPYAVDVLTTGTYPRLPTCIRDKIVPVDPITVTEKRLTLQRLSQVIEYRLVCSELPPQMRRLKIENGRVKFLVEHEFEVTLTLMGDSPTIPWRLLDIAILVEDHQTGDGKSLVHSLQVNYIHRLVQSRLLDNEKPLHDLYRMLHSFCLSLQLEVLHSQIQRLVRERLGDSVRVEEYTPGKCLVVSYWRDQIKKEKDSSVYKLSVHVSEEDEGKPLQISHIPLMTVEEARKVGLSIRSEHLSIEKLIIQTIEVRTHAKLKEFAKDLQKYVDGPCEIKDVPAVLHVPVLNPFTSAEVLRVAIDIQRGTFLTSVPCSNHPVIQEIEENLNGERRHLDKQIAKLRSELALLRCEKSVQQLPASSHRQLPFINFAGHALESLSKHKLYVRVPKQTSYAVVVEVEDVPPKSFVYKYYLLEMATASTENTDNTLVEDNGAVKPFLKAKHLTPINIFSLTHGPYATVFSEGDELELDSLSRKRKLLLGDQEGPPAKMRKESPYFVAPLAFLLAHCEEKLPFVSLTEELTRRNIPHQGIQVDGEGSCMTLTIMDLPNCKGCTPETMDELRKNLLSSKFRIQVRPTRNWIVEFVFTNCPIKTTSPKEQGPIQRVYFSFDLNTDQASKTVQDLLDEWTLVANLYQAVYNFSHFFNDSRTGLQKLIEVRSYNYRKLTIVYGVTQTSLVNIAWRIDTKSFHLTLGTCGQNASTINPHVLVITQLQEELNCANSTDAVANLVQLLNDTWSPLTSINKLSTSPLLGGSTHPKQSMLSFTIIPQSTTHVRITFRNVSCVDVHFRSGKMVAVRDGAISLFDTSKVIDGFTPTPGLKAFLNMFVDETVTGSHPRRRSTTEEDHPLSPIGMDSVEIFLPQNPSVGSPASRPRQDGNLRFQNPMTPPSNPHTPASPSTSRISSVSFLFYFSYVLS
Length1044
PositionTail
OrganismOctopus bimaculoides (California two-spotted octopus)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Mollusca> Cephalopoda> Coleoidea> Octopodiformes> Octopoda> Incirrata> Octopodidae> Octopus.
Aromaticity0.07
Grand average of hydropathy-0.225
Instability index45.84
Isoelectric point7.60
Molecular weight117743.95
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04776
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.28|      17|      31|     299|     315|       1
---------------------------------------------------------------------------
  299-  315 (31.42/21.83)	SVRVEEYTPGKCLVVSY
  332-  348 (30.86/21.29)	SVHVSEEDEGKPLQISH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.55|      18|      39|     243|     260|       2
---------------------------------------------------------------------------
  243-  260 (34.50/21.57)	H....SLQVNYIH....RLVQSRLLD
  273-  298 (22.05/11.22)	HsfclSLQLEVLHsqiqRLVRERLGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.10|      29|      30|      36|      64|       3
---------------------------------------------------------------------------
   36-   64 (48.01/37.25)	QRT...YAEMSVLSELLPRKSDMERKIEIVQF
   66-   97 (45.10/34.50)	QRTrqlFVRLLALVKWANSASKVDKCGEICNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.44|      37|      42|     612|     653|       4
---------------------------------------------------------------------------
  614-  653 (55.06/53.14)	PPAKMRKESPYFVAPLAFL.LAHCEEKLPfvSLTEELtRRN
  655-  692 (64.38/41.39)	PHQGIQVDGEGSCMTLTIMdLPNCKGCTP..ETMDEL.RKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.85|      17|      42|     163|     179|       5
---------------------------------------------------------------------------
  163-  179 (26.55/15.19)	EKRLTLQ..RLSQVIEYRL
  188-  206 (17.97/ 7.78)	MRRLKIEngRVKFLVEHEF
  207-  223 (27.33/15.87)	EVTLTLM..GDSPTIPWRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.78|      45|      85|     735|     779|       6
---------------------------------------------------------------------------
  735-  779 (79.45/64.35)	FSFDLNT.DQASKTVQ......DLLDEWTLVANLYQAVYNFSHFFNDSRTGL
  816-  867 (67.33/53.25)	FHLTLGTcGQNASTINphvlviTQLQEELNCANSTDAVANLVQLLNDTWSPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.96|       9|      30|     407|     416|       7
---------------------------------------------------------------------------
  407-  416 (12.60/ 9.65)	VPAVLHvPVL
  440-  448 (19.36/10.43)	VPCSNH.PVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.51|      32|     819|     125|     159|       9
---------------------------------------------------------------------------
  125-  159 (52.63/44.75)	LPNFpLPYAVDVLTTGTYP.RLPTCIRDKivPVDPI
  947-  979 (54.88/34.89)	LKAF.LNMFVDETVTGSHPrRRSTTEEDH..PLSPI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04776 with Med14 domain of Kingdom Metazoa
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