<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04775

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMFYYGSKKGKQTASDAVNQGIPPQGIPPQSLAPGQSPQQAQQQSQTMQDPINALQNLAMQGTTSAICPQQAERMKGYPQNFPRMMNHQQATAAHIQYQQRHMPARTPVNQPKPVPLQRHDAFMVSQAPPQAQQQAQPPTTSQQPVPPPQTSTQQQPQQQQSAPQQQMVGQQMAVSGPNQLPFQGGNPPSVPRSMVQSPYMSPQQYGQSPSQVQPASNVSQLNTAHSPATQGSHMVHSPANLAAPSPNTHIVPSPVSRNAAMGAPSPGSALNTPGNPGSVGTTASPSEDQAYLEKLKQLSKFIDPLRRMIRKTETEEDNKKDQSHKMKNLLEILSDPSKRLPMTTLLKCEQVLLKMELSKPPSSSDGSGSSSKNGEQHMCQPLLDSIAAHMKSPMLNHTLHRTFGPAVAALRGQPIRVPSPPPTKKPKVSNEKDKLSNILQGEIARLPHRFRISLDPAHHVSSKTVHLICKLDDKNLPSVPPILIVVPEDYPSTSPQCDSNAEDYTATPFLQGVQNALQSSLQKMPDHFSVATLLDTWEMSVRRMCAPTS
Length549
PositionTail
OrganismOctopus bimaculoides (California two-spotted octopus)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Mollusca> Cephalopoda> Coleoidea> Octopodiformes> Octopoda> Incirrata> Octopodidae> Octopus.
Aromaticity0.03
Grand average of hydropathy-0.722
Instability index79.66
Isoelectric point9.41
Molecular weight59758.05
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04775
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     219.16|      28|      30|     129|     156|       1
---------------------------------------------------------------------------
   15-   38 (37.20/10.75)	DAV.NQGIP...P.....QGIPPQSLAP...G...QS......PQ
   39-   69 (30.77/ 7.39)	QAQ.QQSQ......TM.QDPINALQNLA...M...QGttsaicPQ
   96-  129 (33.75/ 8.94)	QYQ.QRHMPartPVNQ.PKPVPLQRHDAfmvS...QA......PP
  130-  157 (52.91/18.96)	QAQ.QQAQP...PTTS.QQPVPPPQTST...Q...QQ......PQ
  179-  210 (34.93/ 9.56)	QLPfQGGNP...PSVP.RSMVQSPYMSP...QqygQS......PS
  258-  286 (29.60/ 6.78)	NAA.MGAPS...PGSAlNTPGNPGSVGT...T...AS......PS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.43|      15|      29|     294|     308|       2
---------------------------------------------------------------------------
  294-  308 (26.35/18.85)	KLKQLSKFI.DPLRRM
  325-  340 (21.08/13.60)	KMKNLLEILsDPSKRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     163.16|      47|      68|     363|     430|       3
---------------------------------------------------------------------------
  363-  395 (47.17/11.70)	......................................SSDGSGSSS.KNGEQHMCQPLLDSIAAHMKSPML
  415-  483 (63.95/42.99)	IRVPSPPPTKKPKVsnekdklsnilqgeiarlphrfriSLDPAHHVS.SKTVHLICK..LDDKNLPSVPPIL
  484-  521 (52.04/12.50)	IVVPEDYPSTSPQC.................................dSNAEDYTATPFLQGVQNALQSSL.
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04775 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IDPLRRMIRKTETEEDNKKDQSHKMKNLLEILSDP
2) KKGKQTASDAVNQGIPPQGIPPQSLAPGQSPQQAQQQSQTMQDPINALQNLAMQGTTSAICPQQAERMKGYPQNFPRMMNHQQATAAHIQYQQRHMPARTPVNQPKPVPLQRHDAFMVSQAPPQAQQQAQPPTTSQQPVPPPQTSTQQQPQQQQSAPQQQMVGQQMAVSGPNQLPFQGGNPPSVPRSMVQSPYMSPQQYGQSPSQVQPASNVSQLNTAHSPATQGSHMVHSPANLAAPSPNTHIVPSPVSRNAAMGAPSPGSALNTPGNPGSVGTTASPSEDQAYLEKLKQ
3) PAVAALRGQPIRVPSPPPTKKPKVSNEKDKLSNI
4) VLLKMELSKPPSSSDGSGSSSKNGEQHMCQPLLDSIA
302
7
405
351
336
297
438
387










Molecular Recognition Features






MoRF SequenceStartStop




1) MFYYGSKKGKQTASDAV
1
17