<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04773

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMSDMQNEWKTTEFRNRVVIQIENALKQSGTKIPKSSVEMENHLHQKAKTKEEYLDLLSKLIIHVSEISKKGKQTASDAVNQGIPPQGIPPQSLAPGQSPQQAQQQSQTMQDPINALQNLAMQGTTSAICPQQAGMMNHQQATAAHIQYQQRHMPARTPVNQPKPVPLQRHDAFMVSQAPPQAQQQAQPPTTSQQPVPPPQTSTQQQPQQQQSAPQQQMVGQQMAVSGPNQLPFQGGNPPSVPRSMVQSPYMSPQQYGQSPSQVQPASNVSQLNTAHSPATQGSHMVHSPANLAAPSPNTHIVPSPVSRNAAMGAPSPGSALNTPGNPGSVGTTASPSEDQAYLEKLKQLSKFIDPLRRMIRKTETEEDNKKDQSHKMKNLLEILSDPSKRLPMTTLLKCEQVLLKMELSKPPSSSDGSGSSSKNGEQHMCQPLLDSIAAHMKSPMLNHTLHRTFGPAVAALRGQPIRVPSPPPTKKPKVSNEKDKLSNILQGEIARLPHRFRISLDPAHHVSSKTVHLICKLDDKNLPSVPPILIVVPEDYPSTSPQCDSNAEDYTATPFLQGVQNALQSSLQKMPDHFSVATLLDTWEMSVRRMCAPTS
Length600
PositionTail
OrganismOctopus bimaculoides (California two-spotted octopus)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Mollusca> Cephalopoda> Coleoidea> Octopodiformes> Octopoda> Incirrata> Octopodidae> Octopus.
Aromaticity0.03
Grand average of hydropathy-0.702
Instability index76.78
Isoelectric point9.24
Molecular weight65497.56
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04773
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     189.55|      28|      30|     180|     207|       1
---------------------------------------------------------------------------
   77-   99 (31.76/ 7.71)	.DAV.NQGIP...P....QGIPPQSLAP...G...QSP
  100-  124 (35.15/ 9.38)	QQAQ.QQSQ......TMQDPINALQNLA...M...QGT
  146-  179 (32.68/ 8.17)	IQYQ.QRHMPartPVNQPKPVPLQRHDAfmvS...QAP
  180-  207 (54.19/18.78)	PQAQ.QQAQP...PTTSQQPVPPPQTST...Q...QQP
  229-  260 (35.77/ 9.69)	NQLPfQGGNP...PSVPRSMVQSPYMSP...QqygQSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     137.95|      32|      88|     403|     435|       3
---------------------------------------------------------------------------
  403-  435 (47.99/25.46)	LLKMELSKPPS....SSDGSGSSSKNGEQHMCQpLLD
  460-  488 (45.17/19.59)	ALRGQPIRVPS....PPPTKKPKVSNEKDK....LSN
  489-  523 (44.79/19.36)	ILQGEIARLPHrfriSLDPAHHVSSKTVHLICK..LD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.73|      13|     234|     291|     303|       5
---------------------------------------------------------------------------
  291-  303 (25.67/10.80)	NLAAPSPNTHI.VP
  311-  324 (19.06/ 6.33)	AMGAPSPGSALnTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.04|      26|      30|     332|     359|       6
---------------------------------------------------------------------------
  332-  359 (40.16/38.65)	TTASPSEDQAYleKLKQLSKFI.DPLRRM
  365-  391 (39.89/30.64)	TEEDNKKDQSH..KMKNLLEILsDPSKRL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04773 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IDPLRRMIRKTETEEDNKKDQSHKMKNLLEILSDP
2) ISKKGKQTASDAVNQGIPPQGIPPQSLAPGQSPQQAQQQSQTMQDPINALQNLAMQGTTSAICPQQAGMMNHQQATAAHIQYQQRHMPARTPVNQPKPVPLQRHDAFMVSQAPPQAQQQAQPPTTSQQPVPPPQTSTQQQPQQQQSAPQQQMVGQQMAVSGPNQLPFQGGNPPSVPRSMVQSPYMSPQQYGQSPSQVQPASNVSQLNTAHSPATQGSHMVHSPANLAAPSPNTHIVPSPVSRNAAMGAPSPGSALNTPGNPGSVGTTASPSEDQAYLEKLKQ
3) PAVAALRGQPIRVPSPPPTKKPKVSNEKDKLSNI
4) VLLKMELSKPPSSSDGSGSSSKNGEQHMCQPLLDSIA
353
67
456
402
387
348
489
438










Molecular Recognition Features






MoRF SequenceStartStop




NANANA