<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04772

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMSDMQNEWKTTEFRNRVVIQIENALKQSGTKIPKSSVEMENHLHQKAKTKEEYLDLLSKLIIHVSEISKKGKQTASDAVNQGIPPQGIPPQSLAPGQSPQQAQQQSQTMQDPINALQNLAMQGTTSAICPQQAERMKGYPQNFPRMMNHQQATAAHIQYQQRHMPARTPVNQPKPVPLQRHDAFMVSQAPPQAQQQAQPPTTSQQPVPPPQTSTQQQPQQQQSAPQQQMVGQQMAVSGPNQLPFQGGNPPSVPRSMVQSPYMSPQQYGQSPSQVQPASNVSQLNTAHSPATQGSHMVHSPANLAAPSPNTHIVPSPVSRNAAMGAPSPGSALNTPGNPGSVGTTASPSEDQAYLEKLKQLSKFIDPLRRMIRKTETEEDNKKDQSHKMKNLLEILSDPSKRLPMTTLLKCEQVLLKMELSKPPSSSDGSGSSSKNGEQHMCQPLLDSIAAHMKSPMLNHTLHRTFGPAVAALRGQPIRVPSPPPTKKPKVSNEKDKLSNILQGEIARLPHRFRISLDPAHHVSSKTVHLICKLDDKNLPSVPPILIVVPEDYPSTSPQCDSNAEDYTATPFLQGVQNALQSSLQKMPDHFSVATLLDTWEMSVRRMCAPTS
Length611
PositionTail
OrganismOctopus bimaculoides (California two-spotted octopus)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Mollusca> Cephalopoda> Coleoidea> Octopodiformes> Octopoda> Incirrata> Octopodidae> Octopus.
Aromaticity0.03
Grand average of hydropathy-0.727
Instability index75.77
Isoelectric point9.34
Molecular weight66945.22
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04772
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     219.16|      28|      30|     191|     218|       1
---------------------------------------------------------------------------
   77-  100 (37.20/11.01)	DAV.NQGIP...P.....QGIPPQSLAP...G...QS......PQ
  101-  131 (30.77/ 7.66)	QAQ.QQSQ......TM.QDPINALQNLA...M...QGttsaicPQ
  158-  191 (33.75/ 9.21)	QYQ.QRHMPartPVNQ.PKPVPLQRHDAfmvS...QA......PP
  192-  219 (52.91/19.20)	QAQ.QQAQP...PTTS.QQPVPPPQTST...Q...QQ......PQ
  241-  272 (34.93/ 9.83)	QLPfQGGNP...PSVP.RSMVQSPYMSP...QqygQS......PS
  320-  348 (29.60/ 7.05)	NAA.MGAPS...PGSAlNTPGNPGSVGT...T...AS......PS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.20|       9|      17|     286|     297|       2
---------------------------------------------------------------------------
  286-  297 (13.59/13.26)	AHSPATqgsHMV
  305-  313 (18.61/ 8.27)	APSPNT...HIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.27|      44|     104|     360|     403|       3
---------------------------------------------------------------------------
  360-  403 (74.63/49.20)	LSKFIDP....LR.RMIRKTETEEDNKKDQSHKMKNLLEILSDPSKRLP
  461-  509 (67.64/43.80)	LHRTFGPavaaLRgQPIRVPSPPPTKKPKVSNEKDKLSNILQGEIARLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04772 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IDPLRRMIRKTETEEDNKKDQSHKMKNLLEILSDP
2) ISKKGKQTASDAVNQGIPPQGIPPQSLAPGQSPQQAQQQSQTMQDPINALQNLAMQGTTSAICPQQAERMKGYPQNFPRMMNHQQATAAHIQYQQRHMPARTPVNQPKPVPLQRHDAFMVSQAPPQAQQQAQPPTTSQQPVPPPQTSTQQQPQQQQSAPQQQMVGQQMAVSGPNQLPFQGGNPPSVPRSMVQSPYMSPQQYGQSPSQVQPASNVSQLNTAHSPATQGSHMVHSPANLAAPSPNTHIVPSPVSRNAAMGAPSPGSALNTPGNPGSVGTTASPSEDQAYLEKLKQ
3) PAVAALRGQPIRVPSPPPTKKPKVSNEKDKLSNI
4) VLLKMELSKPPSSSDGSGSSSKNGEQHMCQPLLDSIA
364
67
467
413
398
359
500
449










Molecular Recognition Features






MoRF SequenceStartStop




NANANA