<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04758

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMIATTDGMPSSAIQCFLVSLSMEQTSCVITSRASASLYVKCHTEASGGVGVVGRPTGPTAATGVDQQNFCVTHVQFVNKDYSDTLVICVGGQNFSWIDFWQLVEQTHSLHRMFHTNSKPNTVYKTPKWMHKATVTHNTMVTAIAGPKLPTMPCGMETSGFTPYIAVAYRNGIIKLIHRYSFQVIYNCCVDQFRELSIPEKRNLNHNQPSHLSVLLQTHSSCGMIGVKDNNIYLFRSVNANDTGVQMSPTYIVLLLEYAATTGWDWWDILLATKQSMIEDICQKLNDNFQKQPTAVQELMCSRLLAIKMALYKSSANSYHLAADCQAKLLLYTIATVFKGILRPRQISSQDNNPAEKLSMLCNKSSESELLILLTNLEFSDFLVDAASLQSFQPLIQWIADFTLHLLGSIPLQQSYSDIPGSLLIRDSSVLSVLRELFVIIRLWGHINPNCLPFFTMNSSIECMSHLFKLLTKAWLCVKEGGSVEYEEGLVSDCCHLTSEVMIRNTRQTFSQDTLGYAIFHQSTPQTFQIGVEPNYVYSCKQKQQFMTIPDITTESKQMYDIVRQINLGEKPAEPVRECSRCGAVSLVQSISSATSMKAWEKRWASACLCGGQWKWTIT
Length618
PositionTail
OrganismOctopus bimaculoides (California two-spotted octopus)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Mollusca> Cephalopoda> Coleoidea> Octopodiformes> Octopoda> Incirrata> Octopodidae> Octopus.
Aromaticity0.09
Grand average of hydropathy-0.033
Instability index45.58
Isoelectric point7.19
Molecular weight69275.05
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04758
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.72|      46|     282|     232|     317|       1
---------------------------------------------------------------------------
  267-  317 (65.23/122.01)	DILLATKQsmIEDICQKLNDNfQKQPTAVQElmCSRLLAIKMALYKSSANS
  550-  595 (80.50/42.76)	DITTESKQ..MYDIVRQINLG.EKPAEPVRE..CSRCGAVSLVQSISSATS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.90|      22|     283|      78|      99|       2
---------------------------------------------------------------------------
   78-   99 (44.19/30.77)	NKDYSDTLVICVGGQNF....SWI.DF
  375-  401 (31.71/20.01)	NLEFSDFLVDAASLQSFqpliQWIaDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     173.78|      50|     303|     179|     229|       5
---------------------------------------------------------------------------
  179-  229 (85.36/64.79)	YSFQVIYNCCvDQFRELSIPEKRNLNHNQPSHLSVLLQTHSSCGMIGVKDN
  485-  534 (88.42/62.53)	YEEGLVSDCC.HLTSEVMIRNTRQTFSQDTLGYAIFHQSTPQTFQIGVEPN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04758 with Med16 domain of Kingdom Metazoa
Unable to open file!