<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04740

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMAYSVNISVEAPIENQIQEITYDGQEIYQAPLTLSENLVKIAQKIDFSKTNGEDVKKETEGGEKGEEDTKDSASFQSSLWPWDSVRNKLRNALTEVCVLADVLAIAKEKHYMVLDPVPQEPAEVKLMIQVYARKKALAGAASVIMMGADRLKNCQNELARNRSTPDFHIELLRLRQNWRLKKVSNSIIGDLSYRTAGSKFPQTGMFEVTKAEEEEKSNTSPPASPSASNNTSGQTHPPNSKASALRVTIPSELQGVAYIEVLCQKDQEDLCSANISLLNNSAHSSNADMHWQQKLEAAQNVLFCKELFSQLAREAVHLRAPIPHMVVGNQIMATVLPGIQLIIGLCHSTGNDKKPSAPPPHKSDHDHVLEHSLHQLLREVHHKNTHHPFPHPSSGPLGPSKRRCLAGPTAADRYELLEMTKSQTLLEQIIQQAQHYFMRLRTEYVLDTIAKEVKDPLIVSHWNALNSPTQSCVKINILTHGYDTVCRTSLVVHIGEKSLKCVCRDGRVMHMSYEPQELRDLIFCQIYQHQITAVQALAKCMGWQFLANSSHLGLGAVEPLGNASSCILASPIGDRMIAVRCEPQTGVQVAIAHSPRKDFFPGQLVRERKWENLGGSFKEVRWDKMEGKNFLNKMELLMASLTSS
Length644
PositionHead
OrganismHabropoda laboriosa
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Apoidea> Apidae> Habropoda.
Aromaticity0.06
Grand average of hydropathy-0.376
Instability index47.48
Isoelectric point7.13
Molecular weight71813.31
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04740
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.61|      19|      66|     310|     328|       1
---------------------------------------------------------------------------
  310-  328 (33.75/16.76)	QLAREAVH..LRAPIPHMVVG
  347-  361 (21.37/ 8.33)	HSTGNDKK..PSAPPPH....
  375-  395 (32.50/15.91)	QLLREVHHknTHHPFPHPSSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     499.87|     170|     388|      22|     216|       2
---------------------------------------------------------------------------
   22-  216 (243.55/226.18)	YDGQEIYQAPlTLSENLVKIAQKIdFSKTNGEDVKKETEggekgeEDTKDS..ASFQSSL.WPWDS.VR.NKLRNALTEVCVLADVLAIAKEKHYMVL.D....PVPQEPAEVKLMI..QVYaRKKALAGAASVIMMGADRLKNcqnelarnRStpdfHIELLRLRQnwrLKKVSNSIIGD.LSYRTAGSKF.PQTGMfEVTKAEEEEK
  414-  597 (256.32/170.70)	YELLEMTKSQ.TLLEQIIQQAQHY.FMRLRTEYVLDTIA......KEVKDPliVSHWNALnSPTQScVKiNILTHGYDTVCRTSLVVHIGEKSLKCVCrDgrvmHMSYEPQELRDLIfcQIY.QHQITAVQALAKCMGWQFLAN........SS....HLGLGAVEP...LGNASSCILASpIGDRMIAVRCePQTGV.QVAIAHSPRK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04740 with Med17 domain of Kingdom Metazoa
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