<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04738

Description Mediator of RNA polymerase II transcription subunit 26
SequenceMGAVVDVITALEKTAITKEVLEITRLGKYINELRRKTNNDALAKRAKDLVRRWRDMVLPSAHSTPQPTPADTAPPALNGAKPHSPALRCFKPQSPALRVLMPPQSPLLRDTTPLRVLSPVLSVHSDHSHSPNASSNKQSITVTSNHRTSSDVPPTLGSSSQHHSMEAVPRTHSSNKRLRKDDVKDQHNYQHHDSDSITESEPFVKKQRLNGENISGNLNLQVPSPTFKERISDQFMESSTDPDDSGPKKRGRKKGSKSMKKQPILEDRVKEKLASISRNPKLKTTQELLADLRARGTNSSINSSALPSQSVESSGMEDILRSSNEQVSKFLRCPQNNLSHRNTVSEASPESRLKPTENCNDVPSKCEESGVVYKEKSVTNVQKSQPEQCQPLTVEEILAKLPPIDPSSIDWSECETELTEDQNSTEYPPRQVTAEDIERLHTQCVEGLNGNFQPKLSSLTSTFNEKPEVKEDVSEINGVNNVYSQPDEEFREWHQMLARPSCNGQILHILPYVIID
Length516
PositionUnknown
OrganismHabropoda laboriosa
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Apoidea> Apidae> Habropoda.
Aromaticity0.03
Grand average of hydropathy-0.838
Instability index63.90
Isoelectric point6.98
Molecular weight57558.77
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04738
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.22|      35|      43|      54|      94|       1
---------------------------------------------------------------------------
   54-   94 (56.06/39.00)	RDMVLPSAhstpqPTPADTAP.....PAL..NGAKPHSPALRCFKpQS
   98-  139 (55.17/25.04)	RVLMPPQS.....PLLRDTTPlrvlsPVLsvHSDHSHSPNASSNK.QS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.86|      26|      28|     141|     168|       2
---------------------------------------------------------------------------
  141-  168 (41.46/27.20)	TVTSNHR.TSSDVPPTlgSSSQHHSMEAV
  171-  197 (43.39/22.74)	THSSNKRlRKDDVKDQ..HNYQHHDSDSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.02|      23|      24|     381|     403|       3
---------------------------------------------------------------------------
  363-  385 (34.75/18.95)	PSKCEESGVVYKEKSVTNVQKSQ
  386-  408 (38.27/21.56)	PEQCQPLTVEEILAKLPPIDPSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      25.18|       8|      21|     200|     209|       4
---------------------------------------------------------------------------
  200-  209 (10.24/10.76)	SEPFvkKQRL
  224-  231 (14.94/ 7.73)	SPTF..KERI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.64|      18|      24|     262|     280|       5
---------------------------------------------------------------------------
  262-  279 (27.59/13.06)	QPILED.RVKEKLASISRN
  286-  304 (23.05/10.27)	QELLADlRARGTNSSINSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.12|      10|      29|     445|     454|       7
---------------------------------------------------------------------------
  445-  454 (19.22/13.62)	VEGLNGNF.QP
  476-  486 (14.90/ 8.99)	INGVNNVYsQP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04738 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FLRCPQNNLSHRNTVSEASPESRLKPTENCND
2) WRDMVLPSAHSTPQPTPADTAPPALNGAKPHSPALRCFKPQSPALRVLMPPQSPLLRDTTPLRVLSPVLSVHSDHSHSPNASSNKQSITVTSNHRTSSDVPPTLGSSSQHHSMEAVPRTHSSNKRLRKDDVKDQHNYQHHDSDSITESEPFVKKQRLNGENISGNLNLQVPSPTFKERISDQFMESSTDPDDSGPKKRGRKKGSKSMKKQPILEDRVKEKLASISRNPKLKTTQELLADLRARGTNSSINSSALPSQSVESSGMEDILRSSNEQV
330
53
361
327










Molecular Recognition Features






MoRF SequenceStartStop




1) GRKKG
2) KKQPILEDRV
3) LVRRWRDMVLP
251
260
49
255
269
59