<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04732

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMTSETQITNIVNDILKVEAIEEAFSCVLVHHPNSESEKISAWQSELTSAMSNLSKEQQENAVRQFLSMAAAMTNHKRLQLLLSLLEHLVTTNVLPARLVCECILSCDKLQYQLEDFWVECFVLIRHIIGGVDYKGVREIMKGCKEKAQTIPARLDASIQPQLKALENVIEYIFDRNACLLPGYFIVNEIQKAFPDGKNWPHWKLAKLLSNFVESFRNTAQMVSIVGHSKMLPVVEHTGYADLINPWVLDTTTLKFSLKGNLPYDEDLLKPQTGLLRYVLEQPYSRDMVCSMLGLQKQQKQRCIALEEQLVELVILAMERAENETLPAEGTDGTVANHYVWLHLSSQLIYFVLFSYAGFPSIVMAIHDKLAGRDLRKGRDHLMWVLLQFISGSIQRNPLSNFLPVLKLYDLLYPEKEPLPVPDYTQALCTHQMAITCIWIHLLKKAQSEHSNIHRPIPHTLKLHHEFLQHLVMPNTSLCMGSDYRIALLCNAYSTNQEYFSRPMAALVDTILGTQKGQQQQLMQTLQNNAALASGPTTPLSMSILDSLTVHSKMSLIHSIVTHVIKLAQSKSNMALAPALVETYSRLLVYTEIESLGVKGFISQLLPQVFKSHAWGTLYTLLEMFSYRMHHIQPHYRVQLLSHLHSLAAVPQTNQTQLHLCVESTALRLITGLGSAEVQPQLSRFLSEPKTLVSAESEELNRALVLTLARSMHVTGTGSDSHSGTWCKELLNTIMQNTPHSWANHTLECFPPVLSEFFQQNSVPKENKQQIKKAVEEEYRNWASMSNENDIIAHFSVPGTPPLFLCLLWKIIFETDRISPIAYKILERIGARALSAHLRKFCDYLVFEFANSVGGGQHVNKCVDTINDMIWKYNIVTIDRLILCLVLRTHEGSDAQVCFFIIQLLLLKAIEFRNRVQEFVKENSPEHWKQSNWHEKHLAFHRKFPEKFAPEGIMEQTSGGPSQYQSLPVYFGNVCLRFLPVFDIVVHRYLEIPAVSKSLETLLEHLGCLYKFHDRPVTYLYNTLHYYEHKLRDRPPLKRRLVSAVLGSLREIRAPGWALSEAYQMYMTRSVDDVVTWMPELDYYIRLVQRIVETMSGTAHFPATDWRFNEFPNPAAHALYVTCVELMAVPVAPNIVANLLLDVVAKGYTVIPSDEIHLWINCVGLLLAALPECYWLALHDRLVETISSPGLANWQYSNLTPFQIFNFNNTHNSLLENKYSYMLALAHSVWHHAGVGQITTMPQFIKEKLQPVVNSEEQLIYACHLIGPTLARFNAERPHCVVDLAVRLYEMLEQVDRLQTHLKYMDPVCDLLYHIKYMFVGDMMKNEVECIIRRLRPALQMRLRFIAHINIDEIQSS
Length1356
PositionTail
OrganismHabropoda laboriosa
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Apoidea> Apidae> Habropoda.
Aromaticity0.09
Grand average of hydropathy-0.039
Instability index47.66
Isoelectric point6.60
Molecular weight155100.06
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04732
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     465.70|     143|     160|     962|    1111|       1
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  962- 1111 (224.08/167.75)	QYQSLPVYfGNVCLRFLpVFDIVVHRYLEIPAVSKSL.....ETLLEHLG..CLY.KFHDRPVTYLY.NT.LHYYEHKL...RDRPPLKRRLVSAVLGSLREIRApGWALSEAYQMYMTRSVDDVVTwMPEldYYIRLVQRIV...ETMSGTAHF..PaTDWRFN.EFP
 1124- 1277 (204.05/126.01)	ELMAVPVA.PNIVANLL..LDVVAKGYTVIPSDEIHLwincvGLLLAALP.eCYWlALHDRLVETIS.SPgLANWQYS.....NLTPFQIFNFNNTHNSLLENKY.SYMLALAHSVWHHAGVGQITT.MPQ..FIKEKLQPVVnseEQLIYACHLigP.TLARFNaERP
 1280- 1342 (37.57/14.90)	..................VVDLAVRLYEMLEQVDR.L.....QTHLKYMDpvCDL.LYH...IKYMFvGD.MMKNEVECiirRLRPALQMRL.............................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.51|      17|      31|     495|     511|       2
---------------------------------------------------------------------------
  495-  511 (29.76/19.22)	NQEYFSRPMAALVDTIL
  528-  544 (28.75/18.31)	NAALASGPTTPLSMSIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.04|      34|     723|     174|     221|       3
---------------------------------------------------------------------------
  187-  221 (59.64/53.76)	NEIQKaFPDGKNWPHWKLA....KLLS...NFVESFRNTAQM
  913-  953 (52.40/21.56)	NRVQE.FVKENSPEHWKQSnwheKHLAfhrKFPEKFAPEGIM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.99|      23|     108|     611|     662|       4
---------------------------------------------------------------------------
  640-  662 (40.25/63.37)	LSHLHSLAAVPQTNQTQLHLCVE
  753-  775 (38.74/ 8.83)	LSEFFQQNSVPKENKQQIKKAVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.17|      25|     108|     158|     182|       5
---------------------------------------------------------------------------
  158-  182 (44.33/29.98)	IQPQLKALENVIEYIFDRN.ACLLPG
  268-  293 (40.85/27.03)	LKPQTGLLRYVLEQPYSRDmVCSMLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.57|      47|     737|      80|     130|      10
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   80-  130 (74.38/59.04)	LLLSLLEHLV..TTNVLP.ARLVCECIlSCDKLQYQLEDFwveC....FVLIRHIIGG
  802-  855 (69.19/42.35)	LFLCLLWKIIfeTDRISPiAYKILERI.GARALSAHLRKF...CdylvFEFANSVGGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.73|      31|     115|     566|     599|      15
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  566-  599 (45.18/43.54)	LAQSKSnmaLAPALVETYSRLLVYTEIESLGVKG
  685-  715 (50.55/38.43)	LSEPKT...LVSAESEELNRALVLTLARSMHVTG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04732 with Med23 domain of Kingdom Metazoa
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