<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04730

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceISLGMLIDFIIQRTYHELTVLAELLPRKTDMERKIEIYTFSARTRQLYVRLLALVKWANSASKVDKSAHIMAFLDKQSLLFVDTADMLARMARKERIVPPDPITPAEKRSTLQRLNQVIQHRLVTGNLLPQMRNLKIEAGRVIFLVEQEFSVSLTVMGDGPIVPWRLLELEILVSDRETGDGKALVHPLQTRYVHQVVQSRLAESSNPLSEVYHILHYFCQSLQLEVLYSQTLRLIRDRLDDHIHVDEYTPGKCLSVSYWRELTNKDPRSELGYKLTVQVDQHDPARPLAIVHVPSLGSKESEIADRAIRSDQLSMECLLVHTIYVRTRSRLLDLKQELQTVLKDVECTLAGSPAILSVPILQPCLRAEHLLVTVDTHTGMLQCHVPQYEAPLVPELTVALNGDHSRLPTLISELRFWITQRRCEKTLQHLPATSHERLPVLLHPDHPMSKISRHRMFVQLHRHPTVILIVAFKEKETVPCEIECSFYLAVVKHSSIEDDPHDDSIETEIPKMYLKVQSLIEFDTFVITHGPFTSVDNEALETSGTKRRSTGPTGRTDASTTLQNRRSKQPAYFIPELAHVVALCDERIPFVTLAQELTRRDIAHQGLQVEANATALVLKLVQLPAPSATISSSCAWHALLKRLLSVSIRVQGKGMAKTWMAEFVFYGSSLSSSHPKEQGLRRPVYFQYEMGTADTMSRTVDALLNDWAQIVHLYSIVHDLAEYFKMEKYSLRNMVSIKSYNYSKLVLSYGPNRGATVTVQWSTNDKAFKLIFGKSPTSTTTNAHSIMKEQLEAHLNRHRNLAQIIHILHETLQPLTSISKLPIIPQLCVYDSGTYCLELRLRGSGLVSLRDGAYSRFDRSYVVDEFTPTQGLKAFLSKYVDESAVSRRRSQSEDDNPPSPVTMDSDGGSGSGNVGFLSHHRSGPQSPAQQRDGLRFHPPLTPPSGSNPHTPASPHTANISQTNQHQSFGSSPATSFNLASPPSLPPNTPNMLPHPSPGSGLVANSPLNPMHVPSPAGLMPTSSPGPCSNVQVGHSPAGSFMQTGHIDGSPFPSSQSMASPAASNWPGSPSVPRPSPARPAQSPGHAALHSPQASDHKTGTHISRVLPQRSWAGAVPTLLTHEALELLCCPSPHPSGLPGPDLSPLERFLGCIYMRRQFQRFIQNDDCLTAINSTEPGVVHFKVESLQCRVGLNPQHLQSLHIKVQPLPEHKDQWTHEELQIIEKFFDTRAAAPPYKPNTLSGFGRMLNLPFNVLKDFVQIMKLELVPGLAQQQQLKWNVQWCLRVPPSGTPIAPTGMAGVLVYRNKILFFLQITRIGLPYQGETLSLVLPLVYDVSTNLTQLAEKRDPSPASAIPAASLQLKRFAEYGANQSECSLFPAVRDLLANLTLPSEPPVMSQVVPSPAGGQVTPTQQIQSPAMQLHSPMAGNQGPPQAAYGIQGMPPMGIMGGPPQ
Length1453
PositionTail
OrganismHabropoda laboriosa
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Apoidea> Apidae> Habropoda.
Aromaticity0.06
Grand average of hydropathy-0.246
Instability index59.69
Isoelectric point8.39
Molecular weight161262.05
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04730
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     536.90|      75|      76|     940|    1014|       1
---------------------------------------------------------------------------
  854-  915 (70.92/26.12)	A......YSRF............DRSYV..........................vdE..F.T.................................PTQGLKA.......FLS.KYV..DESAV..SR.RRSQSEDDNP................PSPVTMD....SDGG..SGSGNV
  916- 1003 (122.95/50.58)	GflshhrSGPQ............SPAQQR....................dglrfhpP..L.T.................................PPSGSNP.......HTP.ASP..HTANI..SQTNQHQSFGSSPATSFNLASP...PSLPPNTPNML....PHPS..PGSGLV
 1004- 1085 (80.90/30.81)	A......NSPL............NPMHVP..........................sPagL.M.................................PTSSPGPcsnvqvgHSP.AGSfmQTGHIdgSPFPSSQSM.ASPAAS.NWPGS...PSVPRPSPAR.....PAQS..PG....
 1086- 1143 (48.85/15.74)	.......HAAL..................................................................................................HSPqASD..H.......KTGTHIS.RVLPQRSWAGAVP...TLLTHEALELLccpsPHPSglPGPDL.
 1144- 1247 (58.20/20.14)	........SPLerflgciymrrqFQRFIQnddcltainstepgvvhfkveslqcrvG..L.N.................................PQHLQSL.......HIK.VQP..LPEHK..DQWT.HEEL..QIIEKF.FDTR...AAAPPYKPNTL..........SGFGRM
 1248- 1331 (38.85/11.04)	L......NLPF............N......................................vlkdfvqimklelvpglaqqqqlkwnvqwclrvPPSG...........TP.IAP..TGMAG..VLVYRNKILFFLQITRIGL......PYQGETLSLVL....P...........
 1340- 1385 (37.29/10.31)	...........................................................L.T.................................QLAEKRD.......PSP.ASA..IPAAS..LQLKRFAEYG...ANQ....SE...CSLFPAVRDLL................
 1386- 1448 (78.94/29.89)	A......NLTL.............P...................................sE.................................PPVMSQV........VP..SP..AGGQV..TPTQQIQ....SPA..MQLHSPmagNQGPPQAAYGI.....QGM..PPMGIM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     169.46|      54|      78|     329|     385|       2
---------------------------------------------------------------------------
  329-  356 (30.88/12.04)	................................................RSRLLDLKQELQTVLKDVEC..TLAGSPAI
  357-  434 (71.51/48.18)	LSVPILqpcLRAEHLLVTVDTHTGMLQCHvpqyeaplvpeltvalngdHSRLPTLISELRFWITQRRCekTLQHLPAT
  437-  487 (67.07/36.76)	ERLPVL...LHPDHPMSKISRHRMFVQLH...............rhptVILIVAFKEK.ETVPCEIEC..SF......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.35|      16|      20|     145|     160|       3
---------------------------------------------------------------------------
  145-  160 (28.17/22.71)	LVEQEFSVSLTVMGDG
  167-  182 (27.17/21.59)	LLELEILVSDRETGDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.45|      39|      80|     687|     738|       6
---------------------------------------------------------------------------
  687-  738 (58.03/62.81)	FQYEMGTADT.........MSRTVDALLN...DWAQIVHlysIVHDlaeyfkmekySLRNMVSI
  769-  819 (56.42/33.91)	FKLIFGKSPTstttnahsiMKEQLEAHLNrhrNLAQIIH...ILHE..........TLQPLTSI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04730 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SAVSRRRSQSEDDNPPSPVTMDSDGGSGSGNVGFLSHHRSGPQSPAQQRDGLRFHPPLTPPSGSNPHTPASPHTANISQTNQHQSFGSSPATSFNLASPPSLPPNTPNMLPHPSPGSGLVANSPLNPMHVPSPAGLMPTSSPGPCSNVQVGHSPAGSFMQTGHIDGSPFPSSQSMASPAASNWPGSPSVPRPSPARPAQSPGHAALHSPQASDHKTGTHISRVLP
2) VMSQVVPSPAGGQVTPTQQIQSPAMQLHSPMAGNQGPPQAAYGIQGMPPMGIMGGPPQ
884
1396
1108
1453










Molecular Recognition Features






MoRF SequenceStartStop




NANANA