<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP04725

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMMGILYEKRPLKRPRLGPPDVYPQEPKQKEDELTSTNVKLGFATMPQMSEEFGTARHCNVTAAKVGAYFNAILAKKEELSTMPDTARKRQQINPKDNFWPVTARTKNGIEAWFKDLSGCKPLIALAKKAPNFNKKEEIFMMLCEYQVPMLRAAWFIKLSSAYTVAVSEAKIKKRQLPDPTTEWTGTLIKFLKDQLSKLQEYYHINNHTSNSMTSGSTMNEEHKLALKQWHYCVQLAKYMFEEGLLDRQELLQWILELLDKIKSSPSEDGILKLLLPLALQYLEEFVQSELLARRLAYLCCRKLAHMCSNVETNGNPQSPSINKSDVNGGKDTATASQMQNPLTAAFNDYLSCPHHRDVIYSLSTIIQVITLECPTALVWNSVGEGKAPSVLNGSPLDYLPCPPTALPCPPTSATNPMLKQLKIAQENIRARSQAAEGKWSCDKWQQSSAGITTTKVLAALDALDRHSFDRMDSTNSLDTLYAKIFTSPPKDNTNERDTKTEYNPQQDSAVVEILCEWAVSAERWGEHRAMAVAKLLEKRQSEVTGETNDNDDKDSICSNGNPPVLPIFQPLLMKFLDMDAPVLDNTTAQSKIQFTNLVHLFSELIRHDVFSHDAYMCTLISRGDLIQGPVASKPGTPSNREPIDEDSLFTGIDLKPAKLEVNDHGRTMDYDDSKIDDDLDKLLQHIKEDQQNSMDAPDSPKEDALAGHGTQEGLDSKIPSSHSRHLLYTTHFPLPQDETCSQHDCNQRHVLLYGVGRVRDDARHIVKKMTKEVCKLFGKKFSIDVAEGGKVKKHSRSEFNFEAITLKFQNLSYFDQHVVTWQCATQVIEMLNTFALAGSSYLPVQEHVAFLFDLMELALNIYGLIDVCIQILKELPEVETQLTVRKSQLVTSYTTSLSLYVVGVLRRYHCCLLLSPEQTTAVFDLLCKVVKHVSNPSDCSSAERCVLAHLYDLYSSCSLLKTKPHGVEAFSNAYPKIRTALYSTLQPTTSSHVYNTQFMVDIFTSPRRGGKIEPQWARQLNETPANRYSFVCNAIVAVCSETDNDKLNDIAITCAELTACCNALNAEWLGILMALCCSSNNSAFYIDVLNQVDVQDLSLHNSLAVFTSILIARHCFSLEDFVVHIALPSLVKACNEGRGDADMEAEAGARLTCHLLLRLFKTVECPQPALYSVSTSPHPLPNGNSRGYSIKLSCDRHLLAAAHNNIRVGPVLAVLKAILVVADATAGKQPPKKPDVPMNHSNKAGGPASVGVGVGVTGENVKGLSDFAQHVLRQICSQEWVLERCLQNPEELCHPDMLLDNMLTPRQAQRLLHMICYPETSTDAFIDQKTHITNILENLEQWSLRMSWLDLQLMYKQFPSGSNDLSQWLDTVAKAAIDVFQLNTMSSKPDKRSGSIWLVAPLVSKLPSAVQGRVLKVAGQVLESGNWSKTAAGRERSRSKSPSLFNHQPFLSLVLTCLKGQDDQREGLLMSLHSQLSQFLNISKEEKNFAAEDPKTREVLQDALQLRFSLVGGVFDTIQRNTTATTDWAILLVQLVSYGVIDLNNNSELFTTIIDMLATLIHSTLVSDSQSEKDENKKHYQNLMKKLKKELGDRNSPSIRYVRQLLPLPKLTMEVITCEPVGCLTDTKGNKIAGFDSIDKKQGLQVCDSQRVSTWEVLEGHKNPAPISWAWFRAVRLERKPLTYQNAHKLLRYHTHSQIRPPSHYLDPPPLPPEDLEPDKKESEPGKADTPMSIDSPGRVTSTVGSSGIGSAVTNGKGKAMKTRRHRRNKGAATPTTPVSQQIQQPPNQLQQMAFGNQQVPVSQQPGIFTGQPPQHQQPWYTNQQTHTPAQQYGYGQQLPPTPVGPRYDRPGMNNQSKQALSHMLRLRLPSNQLISSQQQPNATPVGAPGAFQGMQRQQFIRQQLRAQHGAPNINPQQGMFASQQQQQQPQQQGIYTGMQQGMNQNYAGYGGQQMIPQQQQQQQQQQAPQQAQQQQLLQQQQQQQQQGLINQQQNMMFSNQQQIMGPQRGQEYIPQQRMQPGATRPPYLQAPNVTMNTMGPMGGGVQNQPAPPYRQASGKPGTVGVTGVGTTSVGLQQNQQFQQQQAINQQRMRQQMLAMQQQQQQAQQQQQAQQQQQQQQQGNAGGQQPTPQLVTHLQRHLSQPPQHYQHQPPPY
Length2156
PositionKinase
OrganismHabropoda laboriosa
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Apoidea> Apidae> Habropoda.
Aromaticity0.06
Grand average of hydropathy-0.506
Instability index50.06
Isoelectric point7.98
Molecular weight241165.45
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP04725
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     122.93|      18|      18|    1958|    1975|       1
---------------------------------------------------------------------------
 1958- 1975 (39.18/14.45)	QQQQQQQQQQA..PQQAQQQ
 1979- 1995 (30.12/ 9.37)	QQQQQQQQQGL..INQ.QQN
 2077- 2096 (25.45/ 6.76)	QQNQQFQQQQAinQQRMRQQ
 2115- 2132 (28.19/ 8.29)	QQQQQQQQGNA..GGQQPTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     155.47|      28|      47|    1870|    1897|       2
---------------------------------------------------------------------------
 1764- 1782 (22.78/ 6.74)	RRH...RRN.......KGAATPT..TPVS.QQ
 1783- 1811 (38.36/18.16)	IQQ...PPNQLQQMAFGNQQVPVSqQPGIFTG
 1864- 1894 (45.61/23.48)	MLRlrlPSNQLISSQQQPNATPVG.APGAFQG
 1895- 1921 (25.72/ 8.90)	MQRqqfIRQQLRAQHGAPNINP...QQGMF..
 1923- 1938 (23.00/ 6.90)	.......SQQ...QQQQPQQ......QGIYTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.78|      12|      40|    1268|    1279|       4
---------------------------------------------------------------------------
 1268- 1279 (22.57/13.20)	AQHVLRQICSQE
 1308- 1319 (24.21/14.74)	AQRLLHMICYPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.41|      31|      41|     643|     675|       5
---------------------------------------------------------------------------
  643-  675 (45.89/43.40)	IDEDSLfTGIDL..KPAKLEVNDHGrTMDYDDSKI
  686-  718 (49.51/35.04)	IKEDQQ.NSMDApdSPKEDALAGHG.TQEGLDSKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.20|      40|     101|    1580|    1637|       8
---------------------------------------------------------------------------
 1580- 1620 (65.48/26.18)	YQNLMKKLKKELGDRNSPSIRYVRQlLPLP..KLTMEVITCEP
 1684- 1725 (72.72/37.52)	YQNAHKLLRYHTHSQIRPPSHYLDP.PPLPpeDLEPDKKESEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.00|      33|      52|     482|     514|       9
---------------------------------------------------------------------------
  482-  514 (56.01/39.07)	AKIF...TSPPKDNTNERDTKTEYNPQQDSAVVEIL
  533-  568 (51.99/35.62)	AKLLekrQSEVTGETNDNDDKDSICSNGNPPVLPIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.47|      41|      52|     763|     806|      10
---------------------------------------------------------------------------
  763-  806 (58.30/47.08)	RHIVK.KMTKEVCKLFgKKFSIDVAEGGKVKKHsrSEFNFEAITL
  816-  857 (64.17/40.35)	QHVVTwQCATQVIEML.NTFALAGSSYLPVQEH..VAFLFDLMEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.64|      13|     818|    1245|    1257|      12
---------------------------------------------------------------------------
 1245- 1257 (25.71/15.18)	GGPASVGV.GVGVT
 2059- 2072 (21.94/11.79)	GKPGTVGVtGVGTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     200.75|      49|     818|     369|     417|      13
---------------------------------------------------------------------------
  369-  417 (92.05/52.67)	ITLECPTALV...WNSVGEGKAPSVLNGSPLDYL....PCPPTALPCPPTSATNPM
 1144- 1180 (39.69/18.28)	..................EAEAGARLTCHLLLRLfktvECPQPALYSVSTS.PHPL
 1190- 1238 (69.02/37.54)	IKLSCDRHLLaaaHNNIRVGPVLAVLKAI...LV....VADATAGKQPPKKPDVPM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.87|      26|     818|     987|    1028|      14
---------------------------------------------------------------------------
  949-  974 (47.86/28.42)	HLY......DLYSSCSL.LKTKPHGV....EAFSNAY
  992- 1028 (34.02/41.28)	HVYntqfmvDIFTSPRRgGKIEPQWArqlnETPANRY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      26.36|       9|     113|    1831|    1841|      15
---------------------------------------------------------------------------
 2015- 2025 ( 5.67/ 6.42)	PQQRMQPgAtR
 2145- 2153 (20.69/ 8.76)	PPQHYQH.Q.P
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP04725 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KLLQHIKEDQQNSMDAPDSPKEDALAGHGTQEGLDSKIPS
2) NAHKLLRYHTHSQIRPPSHYLDPPPLPPEDLEPDKKESEPGKADTPMSIDSPGRVTSTVGSSGIGSAVTNGKGKAMKTRRHRRNKGAATPTTPVSQQIQQPPNQLQQMAFGNQQVPVSQQPGIFTGQPPQHQQPWYTNQQTHTPAQQYGYGQQLPPTPVGPRYDRPGMNNQSKQALSHMLRLRLPSNQLISSQQQPNATPVGAPGAFQGMQRQQFIRQQLRAQHGAPNINPQQGMFASQQQQQQPQQQGIYTGMQQGMN
3) NYAGYGGQQMIPQQQQQQQQQQAPQQAQQQQLLQQQQQQQQQGLINQQQNMMFSNQQQIMGPQRGQEYIPQQRMQPGATRPPYLQAPNVTMNTMGPMGGGVQNQPAPPYRQASGKPGTVGVTGVGTTSVGLQQNQQFQQQQAINQQRMRQQMLAMQQQQQQAQQQQQAQQQQQQQQQGNAGGQQPTPQLVTHLQRHLSQPPQHYQHQPPPY
681
1686
1946
720
1944
2156










Molecular Recognition Features






MoRF SequenceStartStop




1) HMLRLRL
2) MMGILYEKRPLKRPRL
3) QQPTPQLVTHLQRHL
1863
1
2128
1869
16
2142